PI3K-IN-63
PI3K-IN-63 is a selective PI3Kα inhibitor with a Ki of 0.35 nM against human targets. PI3K-IN-63 inhibits the phosphorylation of AKT at the S473 site in cellular assays. PI3K-IN-63 reduces the viability of non-small cell lung cancer cell lines carrying PIK3CA mutations. PI3K-IN-63 can be used in studies related to non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 1202041-71-1
- Formula: C17H13Cl2N5OS
- Molecular Weight:406.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PI3K-IN-63 (compound 9) potently inhibits purified PI3Kα enzyme with a Ki of 0.35 nM and exhibits greater than 7000-fold selectivity over purified mTOR enzyme[1].
PI3K-IN-63 is more active in NSCLC cell lines harboring PIK3CA mutations than in other tested cancer cell lines[1].
PI3K-IN-63 (3 μM) has favorable in vitro metabolic stability (HLM ER = 0.3) and does not significantly inhibit major CYP enzymes at 3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1202041-71-1
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Molecular Weight 406.29
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Formula C17H13Cl2N5OS
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SMILES
N#CC1=C(SC(C2=NN=CN2)=C1C=3C=CC(Cl)=CC3Cl)N4CCOCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K-IN-63 Related Classifications
HY-100424 Related Classifications
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