1202041-71-1
Chemical Structure
PI3K-IN-63
- CAS No.: 1202041-71-1
- Formula:C17H13Cl2N5OS
- Molecular Weight:406.29
IUPAC Name: 4-(2,4-dichlorophenyl)-2-morpholino-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile
InChIKey: XPMQWMAEFFQIRZ-UHFFFAOYSA-N
SMILES: N#CC1=C(SC(C2=NN=CN2)=C1C=3C=CC(Cl)=CC3Cl)N4CCOCC4
Biological Activity: PI3K-IN-63 is a selective PI3Kα inhibitor with a Ki of 0.35 nM against human targets. PI3K-IN-63 inhibits the phosphorylation of AKT at the S473 site in cellular assays. PI3K-IN-63 reduces the viability of non-small cell lung cancer cell lines carrying PIK3CA mutations. PI3K-IN-63 can be used in studies related to non-small cell lung cancer[1].
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PI3K-IN-63 | PI3K-IN-63 is a selective PI3Kα inhibitor with a Ki of 0.35 nM against human targets. PI3K-IN-63 inhibits the phosphorylation of AKT at the S473 site in cellular assays. PI3K-IN-63 reduces the viability of non-small cell lung cancer cell lines carrying PIK3CA mutations. PI3K-IN-63 can be used in studies related to non-small cell lung cancer. | |||||||||||||||||||||
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Keywords
