PI3K-IN-58
PI3K-IN-58 (Compound 17f) is a PI3Kα inhibitor (IC50: 0.039 μM). PI3K-IN-58 exhibits significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231 and MDA-MB-453 cell lines with IC50s of 3.48 μM, 1.06 μM, 2.21 μM and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression levels of anti-apoptotic proteins Bcl-XL and Bcl-2 and upregulating the expression of anti-apoptosis protein BAX. PI3K-IN-58 can be used in PI3K-targeted cancer research.
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- CAS. Nr.: 3067572-78-2
- Formel: C22H22N6O3S
- Molecular Weight:450.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PI3Kα 0.039 μM (IC50) |
Bcl-2 |
Bcl-xL |
Bax |
Chemical Information
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CAS. Nr. 3067572-78-2
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Molecular Weight 450.51
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Formel C22H22N6O3S
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SMILES
O=C(NCCO)/C=C/C1=CC2=NC(C3=CC=CC4=C3C=NN4)=NC(N5CCOCC5)=C2S1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PI3K-IN-58 Related Classifications
HY-172886 Related Classifications
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