Cyclocurcumin 

Cyclocurcumin is a potent p38α inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities^[1][2][3].

Cyclocurcumin (10-40 μM; 18 h) leads to significant inhibition in the release of TNF-α in a dose-dependent manner in LPS-stimulated human macrophages^[1].
Cyclocurcumin (5-25 μM) inhibits phenylephrine (HY-B0769)-induced vasocontraction in a concentration-dependent manner (IC₅₀=14.9±1.0 μM) in freshly isolated rat aortic rings^[2].
Cyclocurcumin (5-25 μM; 30 min) inhibits influx of intracellular calcium in a dose-dependent manner. Cyclocurcumin inhibits L-type calcium channel-mediated vasoconstriction in a concentration-dependent manner. The anticontractile effect of Cyclocurcumin is reversible^[2].
Cyclocurcumin has strong activity as a scavenger of ˙OH and ˙OOH free radicals preferentially by its 4′-OH phenolic radical via a hydrogen-atom transfer mechanism in water and a physiological environment^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

368.38

C₂₁H₂₀O₆

153127-42-5

Solid

White to off-white

O=C1CC(C(C=C2)=CC(OC)=C2O)OC(/C=C/C(C=C3)=CC(OC)=C3O)=C1

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Fu M, et al. Cyclocurcumin, a curcumin derivative, exhibits immune-modulating ability and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. Int J Mol Med. 2017 May;39(5):1164-1172.  [Content Brief]

  [2]. Kim K, et al. Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric). J Nat Prod. 2017 Jan 27;80(1):196-200.  [Content Brief]

  [3]. Li Y, et al. Antioxidant properties and free radical scavenging mechanisms of cyclocurcumin. New Journal of Chemistry, 2018, 42(15): 12698-12705.