1. PI3K/Akt/mTOR
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  2. GSK-3
  3. (Rac)-BRD0705

(Rac)-BRD0705 

Cat. No.: HY-116830A
Handling Instructions

(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

(Rac)-BRD0705 Chemical Structure

(Rac)-BRD0705 Chemical Structure

CAS No. : 1597440-03-3

Size Price Stock
10 mM * 1 mL in DMSO USD 318 Ask For Quote & Lead Time
5 mg USD 450 Ask For Quote & Lead Time
10 mg USD 750 Ask For Quote & Lead Time
50 mg USD 2250 Ask For Quote & Lead Time
100 mg USD 3800 Ask For Quote & Lead Time

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Description

(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].

Molecular Weight

321.42

Formula

C₂₀H₂₃N₃O

CAS No.

1597440-03-3

SMILES

O=C1C2=C(N=C3C(C2(CC)C4=CC=CC=C4)=CNN3)CC(C)(C)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (777.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1112 mL 15.5560 mL 31.1119 mL
5 mM 0.6222 mL 3.1112 mL 6.2224 mL
10 mM 0.3111 mL 1.5556 mL 3.1112 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

(Rac)-BRD0705GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3RacemateGSK3αInhibitorinhibitorinhibit

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(Rac)-BRD0705
Cat. No.:
HY-116830A
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