1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase
  3. FM19G11

FM19G11 

Cat. No.: HY-15672
Handling Instructions

FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions.

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FM19G11 Chemical Structure

FM19G11 Chemical Structure

CAS No. : 329932-55-0

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Description

FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions[1][2].

IC50 & Target

HIF-1α[1]

In Vitro

FM19G11 (30-300 nM) inhibits HIFα proteins in the HeLa cell lines[1].
FM19G11 (500 n m) promotes oligodendrocyte differentiation under hypoxia[1].
FM19G11 (300 nM; 3 days) suppresses the mRNA levels of O6-methylguanine DNA-methyltransferase (MGMT) significantly in hypoxic GBM‐XD, hypoxic T98G, and normoxic T98G cells[2].
M19G11 (300 nM; 3 days) significantly enhances the pro‐apoptotic effect of temozolomide (TMZ), although FM19G11 does not induce apoptosis by itself[2].

Cell Viability Assay[2]

Cell Line: GBM‐XD and T98G cells
Concentration: 300 nM
Incubation Time: 3 days
Result: Suppressed MGMT expression significantly in both cell lines in hypoxic culture.
Downregulated MGMT expression substantially inT98G cells in normoxic culture.

Cell Viability Assay[2]

Cell Line: GBM‐XD and T98G cells
Concentration: 300 nM
Incubation Time: 3 days
Result: Had no cytotoxicity by itself.
Enhanced the cytotoxicity of TMZ in hypoxic GBM-XD cells, hypoxic T98G cells, and normoxic T98G cells.
In Vivo

FM19G11 ( intramedullary injection; 1-8 weeks) improve locomotion in severe spinal cord injury (SCI) [3].
FM19G11 ( intramedullary injection; 8 weeks) induces the expression of GAP43, an axon growth marker, and RIP, a marker for myelinated oligodendrocytes at the injury[3].

Molecular Weight

463.40

Formula

C₂₃H₁₇N₃O₈

CAS No.

329932-55-0

SMILES

O=C(OCC(C1=CC=C(C)C=C1)=O)C2=CC=CC(NC(C3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)=O)=C2

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Keywords:

FM19G11HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHypoxia-induciblefactor-1-alphaHIF-1αmTORPI3K/Akt/eNOSnormoxichypoxicInhibitorinhibitorinhibit

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FM19G11
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