2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. FM19G11

FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions.

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FM19G11 Chemical Structure

FM19G11 Chemical Structure

CAS No. : 329932-55-0

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Based on 1 publication(s) in Google Scholar

FM19G11 Related Antibodies

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Description

FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions[1][2].

IC50 & Target

HIF-1α[1]
In Vitro

FM19G11 (30-300 nM) inhibits HIFα proteins in the HeLa cell lines[1].
FM19G11 (500 nM) promotes oligodendrocyte differentiation under hypoxia[1].
FM19G11 (300 nM; 3 days) suppresses the mRNA levels of O6-methylguanine DNA-methyltransferase (MGMT) significantly in hypoxic GBM‐XD, hypoxic T98G, and normoxic T98G cells[2].
M19G11 (300 nM; 3 days) significantly enhances the pro‐apoptotic effect of temozolomide (TMZ), although FM19G11 does not induce apoptosis by itself[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FM19G11 Related Antibodies

Cell Viability Assay[2]

Cell Line: GBM‐XD and T98G cells
Concentration: 300 nM
Incubation Time: 3 days
Result: Had no cytotoxicity by itself.
Enhanced the cytotoxicity of TMZ in hypoxic GBM-XD cells, hypoxic T98G cells, and normoxic T98G cells.

Western Blot Analysis[2]

Cell Line: GBM‐XD and T98G cells
Concentration: 300 nM
Incubation Time: 3 days
Result: Suppressed MGMT expression significantly in both cell lines in hypoxic culture.
Downregulated MGMT expression substantially inT98G cells in normoxic culture.
In Vivo

FM19G11 ( intramedullary injection; 1-8 weeks) improves locomotion in severe spinal cord injury (SCI)[3].
FM19G11 ( intramedullary injection; 8 weeks) induces the expression of GAP43, an axon growth marker, and RIP, a marker for myelinated oligodendrocytes at the injury[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

463.40

Formula

C23H17N3O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC(C1=CC=C(C)C=C1)=O)C2=CC=CC(NC(C3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (215.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1580 mL 10.7898 mL 21.5796 mL
5 mM 0.4316 mL 2.1580 mL 4.3159 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1580 mL 10.7898 mL 21.5796 mL 53.9491 mL
5 mM 0.4316 mL 2.1580 mL 4.3159 mL 10.7898 mL
10 mM 0.2158 mL 1.0790 mL 2.1580 mL 5.3949 mL
15 mM 0.1439 mL 0.7193 mL 1.4386 mL 3.5966 mL
20 mM 0.1079 mL 0.5395 mL 1.0790 mL 2.6975 mL
25 mM 0.0863 mL 0.4316 mL 0.8632 mL 2.1580 mL
30 mM 0.0719 mL 0.3597 mL 0.7193 mL 1.7983 mL
40 mM 0.0539 mL 0.2697 mL 0.5395 mL 1.3487 mL
50 mM 0.0432 mL 0.2158 mL 0.4316 mL 1.0790 mL
60 mM 0.0360 mL 0.1798 mL 0.3597 mL 0.8992 mL
80 mM 0.0270 mL 0.1349 mL 0.2697 mL 0.6744 mL
100 mM 0.0216 mL 0.1079 mL 0.2158 mL 0.5395 mL
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FM19G11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FM19G11329932-55-0HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHypoxia-induciblefactor-1-alphaHIF-1αmTORPI3K/Akt/eNOSnormoxichypoxicInhibitorinhibitorinhibit

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