PX-478 (Standard)
PX-478 (Standard) is the analytical standard of PX-478 (HY-10231). This product is intended for research and analytical applications. PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis.
For research use only. We do not sell to patients.
- CAS No.: 685898-44-6
- Formula: C13H20Cl4N2O3
- Molecular Weight:394.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 685898-44-6
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Molecular Weight 394.12
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Formula C13H20Cl4N2O3
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SMILES
[O-][N+](CCCl)(CCCl)C(C=C1)=CC=C1C[C@H](N)C(O)=O.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PX-478 (Standard) Related Classifications
HY-10231R Related Classifications
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Keywords
- PX-478 (Standard)
- 685898-44-6
- Reference Standards
- HIF/HIF Prolyl-Hydroxylase
- VEGFR
- Autophagy
- Hypoxia-inducible factors
- HIFs
- HIF-PH
- Vascular endothelial growth factor receptor
- vascular endothelial growth factor
- MCF-7 human breast cancer cells
- THP-1 macrophage foam cells
- hypoxia-inducible factor-1α
- PC3 human prostate carcinoma cells
- DU 145 human prostate carcinoma cells
- pancreatic β-cell
- VEGF
- ApoE-/- mice
- HIF-1α
- Inhibitor
- inhibitor
- inhibit