2. PI3K/Akt/mTOR
  3. PI3K
  4. STX-478

STX-478 (compound 80) is an oral CNS-penetrant allosteric mutant-selective PI3Kα inhibitor. STX-478 shows robust and durable tumor regression and can be used in cancer research.

For research use only. We do not sell to patients.

STX-478 Chemical Structure

STX-478 Chemical Structure

CAS No. : 2883540-92-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 918 In-stock
Solution
10 mM * 1 mL in DMSO USD 918 In-stock
Solid
1 mg USD 410 In-stock
5 mg USD 1040 In-stock
10 mg USD 1650 In-stock
25 mg USD 3340 In-stock
50 mg USD 5350 In-stock
100 mg USD 8600 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

STX-478 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

STX-478 (compound 80) is an oral CNS-penetrant allosteric mutant-selective PI3Kα inhibitor. STX-478 shows robust and durable tumor regression and can be used in cancer research[1].

IC50 & Target

PI3Kα[1].
In Vitro

STX-478 (0-10,000 nM; 1 h) demonstrates selectivity for MCF10A cells harboring the H1047R kinase-domain mutation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STX-478 Related Antibodies

Immunofluorescence[1]

Cell Line: MCF10A cells
Concentration: 0-10,000 nM
Incubation Time: 1 h
Result: Targeted the MCF10A cells (with the H1047R kinase domain mutation).
In Vivo

STX-478 (30, 100 mg/kg; p.o.; single daily for 28 days) dose-dependently reduces tumor volume in a CAL-33 xenograft mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice (CAL-33 xenograft model)[1].
Dosage: 30, 100 mg/kg
Administration: Oral administration
Result: Showed a dose-dependent reduction in tumor volume.
Molecular Weight

401.29

Formula

C16H12F5N5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=C(C=N1)NC(N[C@H](C2=C(C3=CC(F)=CC(F)=C3O2)C)C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (622.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4920 mL 12.4598 mL 24.9196 mL
5 mM 0.4984 mL 2.4920 mL 4.9839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.60%

COA (248 KB) HNMR (271 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4920 mL 12.4598 mL 24.9196 mL 62.2991 mL
5 mM 0.4984 mL 2.4920 mL 4.9839 mL 12.4598 mL
10 mM 0.2492 mL 1.2460 mL 2.4920 mL 6.2299 mL
15 mM 0.1661 mL 0.8307 mL 1.6613 mL 4.1533 mL
20 mM 0.1246 mL 0.6230 mL 1.2460 mL 3.1150 mL
25 mM 0.0997 mL 0.4984 mL 0.9968 mL 2.4920 mL
30 mM 0.0831 mL 0.4153 mL 0.8307 mL 2.0766 mL
40 mM 0.0623 mL 0.3115 mL 0.6230 mL 1.5575 mL
50 mM 0.0498 mL 0.2492 mL 0.4984 mL 1.2460 mL
60 mM 0.0415 mL 0.2077 mL 0.4153 mL 1.0383 mL
80 mM 0.0311 mL 0.1557 mL 0.3115 mL 0.7787 mL
100 mM 0.0249 mL 0.1246 mL 0.2492 mL 0.6230 mL
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STX-478 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STX-4782883540-92-7STX478STX 478PI3KPhosphoinositide 3-kinasecancertumorMCF10AH1047RInhibitorinhibitorinhibit

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