JNJ-3790339
JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC50 of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation.
For research use only. We do not sell to patients.
- CAS No.: 93076-87-0
- Formula: C30H33N3OS
- Molecular Weight:483.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 9.6 μM (DGKα)[1]
JNJ-3790339 (5-40 μM; 48 h) exhibits cytotoxic efficacy against A375, U251 and Jurkat T[1].
JNJ-3790339 (5 μM; 6 h) promotes activation of primary murine T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A375, U251 and Jurkat T
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Concentration:5, 15, 25 and 40 μM
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Incubation Time:48 h
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Result:Exhibited cytotoxic efficacy against cancer cells in a dose-dependent manner.
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Cell Line:Jurkat T
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Concentration:5 μM
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Incubation Time:6 h
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Result:Displayed high activation response with significantly increased CD69 and TNFα expression.
Chemical Information
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CAS No. 93076-87-0
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Molecular Weight 483.67
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Formula C30H33N3OS
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SMILES
O=C1C(CCN2CC/C(CC2)=C(C3=CC=C(C)C=C3)\C4=CC=C(C)C=C4)=C(C)N=C5SC=C(C)N51
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNJ-3790339 Related Classifications
HY-148174 Related Classifications
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