OBHS
OBHS is an estrogen receptor α (ERα) inhibitor. OBHS can also be used as a blowing agent.
For research use only. We do not sell to patients.
- CAS No.: 870614-18-9
- Formula: C24H20O6S
- Molecular Weight:436.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
>100 μM
Compound: OBHS
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Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
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[PMID: 25993269] |
| HEK-293T | EC50 |
0.095 μM
Compound: OBHS
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Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as stimulation of transcriptional activity after 24 hrs by luciferase reporter gene assay
Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as stimulation of transcriptional activity after 24 hrs by luciferase reporter gene assay
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[PMID: 25993269] |
| HEK-293T | IC50 |
0.014 μM
Compound: OBHS
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Antagonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay
Antagonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay
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[PMID: 25993269] |
| HEK-293T | IC50 |
0.581 μM
Compound: OBHS
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Antagonist activity at ER-beta (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay
Antagonist activity at ER-beta (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay
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[PMID: 25993269] |
| MCF7 | IC50 |
20.9 μM
Compound: OBHS
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
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[PMID: 25993269] |
| Vero | IC50 |
>100 μM
Compound: OBHS
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Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay
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[PMID: 25993269] |
Chemical Information
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CAS No. 870614-18-9
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Molecular Weight 436.48
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Formula C24H20O6S
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SMILES
O=S([C@H]1C[C@@H]2C(C3=CC=C(C=C3)O)=C([C@H]1O2)C4=CC=C(C=C4)O)(OC5=CC=CC=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OBHS Related Classifications
HY-146424 Related Classifications
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