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Cat. No.: HY-146424

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OBHS

OBHS is an estrogen receptor α (ERα) inhibitor. OBHS can also be used as a blowing agent.

For research use only. We do not sell to patients.

CAS No.: 870614-18-9
Formula: C₂₄H₂₀O₆S
Molecular Weight:436.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

OBHS Chemical Structure

CAS No.: 870614-18-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

OBHS is an estrogen receptor α (ERα) inhibitor. OBHS can also be used as a blowing agent^[1]^[2].

All Estrogen Receptor/ERR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	>100 μM Compound: OBHS	Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25993269]
HEK-293T	EC₅₀	0.095 μM Compound: OBHS	Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as stimulation of transcriptional activity after 24 hrs by luciferase reporter gene assay Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as stimulation of transcriptional activity after 24 hrs by luciferase reporter gene assay	[PMID: 25993269]
HEK-293T	IC₅₀	0.014 μM Compound: OBHS	Antagonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay Antagonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay	[PMID: 25993269]
HEK-293T	IC₅₀	0.581 μM Compound: OBHS	Antagonist activity at ER-beta (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay Antagonist activity at ER-beta (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay	[PMID: 25993269]
MCF7	IC₅₀	20.9 μM Compound: OBHS	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25993269]
Vero	IC₅₀	>100 μM Compound: OBHS	Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25993269]

Chemical Information

CAS No. 870614-18-9
Molecular Weight 436.48
Formula C₂₄H₂₀O₆S
SMILES

O=S([C@H]1C[C@@H]2C(C3=CC=C(C=C3)O)=C([C@H]1O2)C4=CC=C(C=C4)O)(OC5=CC=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He M, et al. Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer. Eur J Med Chem. 2020 Jun 1;195:112281. [Content Brief]

[2]. Srikham J, et al. Foamability of Natural rubber (NR)/Poly (butylenes adipate-co-terephthalate)(PBAT) Thermoplastic Vulcanizate with OBSH as a blowing agent. 2020 IOP Conf. Ser.: Mater. Sci. Eng. 965 012018.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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OBHS

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

OBHS Related Classifications

HY-146424 Related Classifications