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14-3-3 eta/YWHAH Inhibitors

" in MedChemExpress (MCE) Product Catalog:

標的別:	Akt (2) Amylin Receptor (1) Amyloid-β (1) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (1) Apoptosis (15) Autophagy (4) Bacterial (6) Bcl-2 Family (2) Biochemical Assay Reagents (2) Calcium Channel (1) Caspase (5) COX (1) DNA/RNA Synthesis (3) Drug Derivative (4) Drug Metabolite (1) Endogenous Metabolite (3) Endothelin Receptor (82) Estrogen Receptor/ERR (5) Ferroptosis (1) Fluorescent Dye (2) GSK-3 (1) Hippo (MST) (1) HIV (2) HSV (1) IKK (1) Influenza Virus (1) Insulin Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (5) Keap1-Nrf2 (1) MARCKS (2) MicroRNA (8) Mitochondrial Metabolism (1) MMP (2) Molecular Glues (6) NF-κB (2) Nucleoside Antimetabolite/Analog (1) PARP (2) PDGFR (2) Phosphatase (3) PKA (1) PKC (7) Prostaglandin Receptor (1) PROTAC Linkers (1) PROTACs (2) RABV (1) Radionuclide-Drug Conjugates (RDCs) (1) Raf (2) Reactive Oxygen Species (ROS) (1) Reference Standards (14) SARS-CoV (1) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (3) SOD (1) Tau Protein (1) TGF-β Receptor (4) Tie (3) TNF Receptor (1) Toll-like Receptor (TLR) (3) VEGFR (1) YAP (1) α-synuclein (1)
研究分野別:	Cancer (50) Cardiovascular Disease (76) Endocrinology (28) Infection (11) Inflammation/Immunology (22) Metabolic Disease (19) Neurological Disease (12)
Oligonucleotides:	miRNA mimics (2) Adenosine (1) miRNA antagomirs (2) miRNA agomirs (2) MicroRNAs (8) Nucleoside Analogs (1) Rat Pre-designed siRNA Sets (1) miRNA inhibitors (2) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

157

阻害剤およびアゴニスト

スクリーニングライブラリ

蛍光色素

生化学アッセイ試薬

ペプチド

天然物

組換えタンパク質

同位体標識化合物

抗体

オリゴヌクレオチド

Targets Recommended: Serpin

製品番号	製品名	Target	研究分野	構造式

HY-14184

Macitentan 10+ Cited Publications ACT-064992	Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Macitentan (ACT-064992) is an orally active, non-peptide dual *ETA* and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

HY-A0013

Bosentan Maximum Cited Publications 30 Publications Verification	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-10088

Zibotentan 1 Publications Verification ZD4054	Endothelin Receptor Apoptosis	Endocrinology Cancer
Zibotentan (ZD4054) is a potent, selective and orally active *endothelin A (ET_A)* receptor antagonist with a K_i** of 13 nM. Zibotentan has no inhibitory effect on ETB. Zibotentan has anticancer effects and can be used for castration-resistant prostate cancer (CRPC) research .

HY-15403

Atrasentan 5+ Cited Publications ABT-627; (+)-A 127722; A-147627	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Atrasentan (ABT-627) is an endothelin receptor antagonist with IC₅₀ of 0.0551 nM for ET_A .

HY-122815

Fusicoccin Fusicoccin A	Apoptosis	Cancer
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific *14-3-3* protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-A0013A

Bosentan hydrate Maximum Cited Publications 30 Publications Verification	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-115501

(E)-FOBISIN101	Ser/Thr Protease	Cancer
(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC₅₀ values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research .

HY-12307

(-)-Indolactam V 2 Publications Verification Indolactam V	PKC	Cancer
(-)-Indolactam V is a PKC activator, with K_is of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and K_ds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

HY-101985

BV02 3 Publications Verification	Bacterial PARP Caspase Apoptosis Autophagy Akt	Infection Neurological Disease Inflammation/Immunology
BV02 is a *14-3-3* inhibitor and an antibacterial agent. BV02 enhances the cleavage of PARP and caspase-3. BV02 induces Apoptosis, Autophagy, and enhances Akt activation. BV02 has anti-B. melitensis infection and epilepsy-promoting effects. BV02 can also be used in colitis research.

HY-15403A

Atrasentan hydrochloride 5+ Cited Publications ABT-627 hydrochloride; (+)-A 127722 hydrochloride; A-147627 hydrochloride	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective endothelin A receptor antagonist with an IC₅₀ of 0.0551 nM for ET_A .

HY-12462

WS3	GSK-3 Keap1-Nrf2 Ferroptosis IKK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
WS3 is an allosteric inhibitor of *14-3-3* (14-3-3ζ: K_d = 2.29 μM). WS3 activates GSK3β by disrupting the binding of *14-3-3-pGSK3β, promotes the ubiquitination and degradation of NRF2, and inhibits the NRF2-ARE* signaling pathway (IC₅₀ = 135 nM). It exerts antioxidant inhibition and chemotherapeutic/ferroptosis sensitizing effects in tumors with hyperactivated NRF2. WS3 binds to EBP1/IKKε and promotes the proliferation of β cells and retinal pigment epithelial (RPE) cells, which can be applied to islet regeneration and RPE expansion transplantation . WS3 is applicable to research related to age-related macular degeneration, retinal degeneration and non-small cell lung cancer .

HY-B1433

Perindoprilat S 9780	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC₅₀ value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research .

HY-17352

Clazosentan Ro 61-1790; VML 588; AXV-034343	Endothelin Receptor	Cardiovascular Disease
Clazosentan (Ro 61-1790) is a selective *endothelin A (ET_A)* receptor** antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction .

HY-177590

14-3-3-IN-2	MMP	Others
14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC₅₀ of 15 nM. 14-3-3-IN-2 can disrupt the interaction of 14-3-3α with aminopeptidase N and down-regulate 14-3-3α increased MMP-1 mRNA levels .

HY-15895S

Aprocitentan-d4 ACT-132577-d₄	Isotope-Labeled Compounds Endothelin Receptor	Cardiovascular Disease Endocrinology
Aprocitentan-d₄ is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent .

HY-P1380A

Difopein TFA	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein TFA is a 14-3-3 protein inhibitor. Difopein TFA acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates Bcl-2, upregulates Bax, activates caspase-9 and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein TFA serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein TFA is applicable to glioma-related research .

HY-NP143

Nerve Growth Factor 2.5S,murine submaxillary gland	Biochemical Assay Reagents	Neurological Disease
Nerve Growth Factor 2.5S, murine submaxillary gland is a neurotrophic polypeptide required for normal growth and development of sympathetic and embryonic sensory neurons and certain cholinergic neurons in the central nervous system. Nerve Growth Factor 2.5S, murine submaxillary gland has only β-subunit , and shows nerve growth-promoting activity .

HY-17351

Tezosentan RO 610612	Endothelin Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA₂s of 9.5, 7.7 for ET_A and ET_B receptors, respectively.

HY-P1039A

R18 TFA PHCVPRDLSWLDLEANMCLP TFA	Raf	Cancer
R18 TFA is a peptide antagonists of *14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3* to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1 .

HY-P0202A

Endothelin 1 (swine, human) TFA Maximum Cited Publications 8 Publications Verification ET-1 (swine, human) TFA	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human) (ET-1) TFA is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 TFA acts through two types of receptors ET_A and ET_B .

HY-146302

14-3-3η Protein inhibitor 1 2 Publications Verification	Apoptosis	Cancer
14-3-3η Protein inhibitor 1 (Compound C11) is a *14-3-3η* protein inhibitor with a K_D of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability .

HY-117664

PNR-7-02	DNA/RNA Synthesis	Cancer
PNR-7-02 is a dual Rev1 and human DNA polymerase η (hpol η) inhibitor, with an IC₅₀ value of 8 μM against hpol η. PNR-7-02 binds to hpol η to disrupt the orientation of template DNA and block the catalytic function of hpol η. When used in combination with Cisplatin (HY-17394), PNR-7-02 induces DNA damage and replication stress in cells with intact hpol η function. PNR-7-02 can be used in mechanism studies related to chronic myeloid leukemia and ovarian cancer .

HY-15404

Darusentan Lu-135252	Endothelin Receptor	Cardiovascular Disease Endocrinology
Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a K_i of 1.4 nM to the ET-A receptor and a K_i of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors . Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a K_i of 13 nM .

HY-119757

Tyrphostin AG1433 SU1433; AG1433	PDGFR VEGFR	Cancer
Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC₅₀s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation .

HY-14184S

Macitentan-d4 ACT-064992-d₄	Isotope-Labeled Compounds Endothelin Receptor Apoptosis	Cardiovascular Disease
Macitentan-d₄ is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

HY-14184R

Macitentan (Standard) ACT-064992 (Standard)	Reference Standards Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Macitentan (Standard) is the analytical standard of Macitentan. This product is intended for research and analytical applications. Macitentan (ACT-064992) is an orally active, non-peptide dual *ETA* and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

HY-169905

*GR–14-3-3* stabilizer-1**	Molecular Glues	Others
GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue stabilizer that can be used to prepare molecular glues targeting glucocorticoids (GR) and block the interaction between GR and 14-3-3 .

HY-N1433

Phytolaccagenin	Bacterial	Infection Inflammation/Immunology
Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae. Phytolcaccagenin has antifungal activity, anti-inflammatory activity and lower toxicity

HY-R00278

*hsa-miR-143-3p mimic*	MicroRNA	Cancer
hsa-miR-143-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-143-3p mimic hsa-miR-143-3p mimic

HY-W1005067

EN171	Molecular Glues Hippo (MST) Estrogen Receptor/ERR	Others
EN171 is a covalent ligand that covalently targets both C38 and C96 on *14-3-3* to enhance *14-3-3* interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent *14-3-3* recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol .

HY-130326

RAPTA-C Ru(η6-p-cymene)Cl2(pta)	Apoptosis Caspase	Cardiovascular Disease Cancer
RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. RAPTA-C exhibits cell growth inhibition by triggering G(2)/M phase arrest in cancer cells. RAPTA-C also enhances the levels of p53 and triggers the mitochondrial Apoptotic pathway, resulting in cytochrome C release and caspase-9 activation. RAPTA-C reduces the growth of tumors with the inhibition of angiogenesis in a ovarian carcinoma model .

HY-B1433R

Perindoprilat (Standard) S 9780 (Standard)	Angiotensin-converting Enzyme (ACE) Reference Standards	Cardiovascular Disease
Perindoprilat (Standard) is the analytical standard of Perindoprilat. This product is intended for research and analytical applications. Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research .

HY-P2496

Endothelin 1 (swine, human), Alexa Fluor 488-labeled	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of *ETA/ETB* receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-156786

TLD-1433	Reactive Oxygen Species (ROS) Influenza Virus SARS-CoV HSV	Infection
TLD-1433 is the fourth-generation ruthenium (II) based photodynamic compound (PDC). TLD-1433 is activated by green light (525 ± 25 nm) and efficiently generates ROS to achieve pathogen inactivation. After photoinactivation, TLD-1433 significantly induces lipid peroxidation of the cell membrane, which can directly damage the integrity of the viral envelope. TLD-1433 has ID₅₀ for enveloped viruses (such as H1N1 influenza virus, coronavirus OC43, HSV-1, Zika virus) is as low as nanomolar level; for non-enveloped viruses (such as adenovirus Ad5, mammalian rotavirus MRV), a concentration of micro-molar level is required for inactivation. TLD-1433 has antigen retention property and can be used for the preparation of inactivated vaccines .

HY-P1039

R18 PHCVPRDLSWLDLEANMCLP	Raf	Cancer
R18 is a peptide antagonists of *14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3* to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1 .

HY-123744

PD-156707	Endothelin Receptor	Cardiovascular Disease Neurological Disease
PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist. PD-156707 binds to human *ET-A* and ET-B receptors with K_i values of 0.17 nM and 133.8 nM, respectively. PD-156707 shows reversal of established chronic hypoxic pulmonary hypertension in rats. PD-156707 can be used for the study of diseases associated with abnormal *ET-A* receptor activation, particularly pulmonary hypertension, stroke, and heart failure .

HY-175872

14-3-3σ/ERα stabilizer-2	Estrogen Receptor/ERR Molecular Glues	Others
14-3-3σ/ERα stabilizer-2 (Compound 41) is a covalent 14-3-3σ/ERα stabilizer with a K_d of 10.1 nM. 14-3-3σ/ERα stabilizer-2 significantly decreases the dissociation rate of ERα, stabilizing the binary ERα/14-3-3σ interaction. 14-3-3σ/ERα stabilizer-2 can be used for molecular glues research .

HY-106994A

Nebentan potassium YM598	Endothelin Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Nebentan potassium (YM598) is a potent, selective and orally active non-peptide *endothelin ET_A* receptor** antagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [ ¹²⁵I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K_i of 0.697 nM and 569 nM, respectively . YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo .

HY-169081

QS-57	PROTACs Molecular Glues	Others
QS-57 is a PROTAC targeting BRD4. QS-57 can be used as a 14-3-3 molecular glue. (Red: EN171 (HY-W1005067), black: (2-Aminoethyl) carbamic acid (HY-W398806), Blue: JQ-1 (carboxylic acid) (HY-78695)) .

HY-162838

TCF199	Estrogen Receptor/ERR	Others
TCF199 is an allosteric stabilizer that stabilizes the 14-3-3/TAZ peptide interaction, binding to the 14-3-3ζ/E R α peptide and 14-3-3ζ/Chibby peptide. TCF199 has a Kd value of 122 μM for its interaction with 14-3-3/TAZ .

HY-135283

ABT-546 A-216546	Endothelin Receptor	Cardiovascular Disease Endocrinology
ABT-546 (A-216546), a chemical probe, is a potent, highly selective and active *endothelin ET_A* receptor antagonist with a K_i** of 0.46 nM for [ ¹²⁵I]endothelin-1 binding to cloned human endothelin ET_A. ABT-546 is >25,000-fold more selective for the ET_A receptor than for the ET_B receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC₅₀ of 0.59 nM and 3 nM, respectively .

HY-13711

S-1255	Endothelin Receptor	Cardiovascular Disease
S-1255 is an orally active and highly selective *endothelin ETA* receptor antagonist (K_d**=0.39 nM). S-1255 blocks vasoconstriction and sustains hypotensive effects in hypertensive rats. S-1255 is promising for research of hypertension and cardiovascular disorders .

HY-118497

BMS 182874	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
BMS 182874 is an orallyactive, highly selective endothelin receptor (ET_A receptor) antagonist, with IC₅₀ value of 0.150 μM, K_i of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research .

HY-161611

14-3-3-IN-1	YAP	Others
14-3-3-IN-1 (Compound 2) is an inhibitor for 14-3-3 proteins in Arabidopsis thaliana, with an IC₅₀ of 1.21 μM. 14-3-3-IN-1 exhibits different inhibitory activities against different 14-3-3 isomers. 14-3-3-IN-1 promotes the closure of stomata on leaves .

HY-P5885

PKCη pseudosubstrate inhibitor,myristoylated	PKC	Others
PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of PKCη .

HY-156125

14-3-3σ/ERα stabilizer-1	Estrogen Receptor/ERR	Others
14-3-3σ/ERα stabilizer-1 (Compound 181) is a covalent *14-3-3σ*/ERα stabilizer. 14-3-3σ/ERα stabilizer-1 can be used for research of molecular glues .

HY-19210

SB-209670	Endothelin Receptor	Cardiovascular Disease
SB-209670 is an extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist. SB 209670 selectively inhibits binding of 125I-labeled ET-1 to cloned human ET receptor subtypes ETA and ETB (K_i=0.2 and 18 nM, respectively). SB 209670 produces a dose-dependent reduction in blood pressure in hypertensive rats, protects from ischemia-induced neuronal degeneration in a gerbil stroke model, and attenuates neointima formation following rat carotid artery balloon angioplasty .

HY-19263

BMS-193884	Endothelin Receptor	Cardiovascular Disease
BMS-193884 is a selective, orally active, and competitive *ET_A* antagonist with 10000-fold greater affinity for the human ET_A receptor (K_i=1.4 nM) than for the ET_B receptor .

HY-153463

Diosuxentan SC0062	Endothelin Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Diosuxentan is an inhibitor of *ET_A*. Diosuxentan can be used in research for cardiovascular, renal and neuronal inflammation diseases .

HY-10383

J-104132	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
J-104132 (L-753037) is a potent, orally active, selective and competitive ETA/ETB receptor antagonist with K_i of 0.034 nM for ETA and 0.104 nM for ETB receptors. J-104132 inhibits Endothelin-1 (ET-1) (HY-P71446)-induced signaling and vascular contractions in vitro. J-104132 alleviates hypertension, vascular remodeling, and diabetic endothelial dysfunction in vivo by dual ETA/ETB blockade. J-104132 can be used for research on diabetic vascular complications ^[1][3].

製品番号	製品名

HY-L143

Marine-Sourced Natural Product Library

63 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 63 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

HY-L006

GPCR/G Protein Compound Library

3,422 compounds

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.

MCE provides a unique collection of 3,422 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

製品番号	製品名	Type

HY-NP143

Nerve Growth Factor 2.5S,murine submaxillary gland	生化学アッセイ試薬
Nerve Growth Factor 2.5S, murine submaxillary gland is a neurotrophic polypeptide required for normal growth and development of sympathetic and embryonic sensory neurons and certain cholinergic neurons in the central nervous system. Nerve Growth Factor 2.5S, murine submaxillary gland has only β-subunit , and shows nerve growth-promoting activity .

HY-159671

3D-Monophosphoryl Lipid (14) 3D-MPL (14)	生化学アッセイ試薬
3D-Monophosphoryl Lipid (14) (3D-Monophosphoryl Lipid (14)) is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .

製品番号	製品名	Target	研究分野

HY-P0202

Endothelin 1 (swine, human) Maximum Cited Publications 8 Publications Verification ET-1 (swine, human)	Endothelin Receptor	Metabolic Disease Inflammation/Immunology
Endothelin 1 (swine, human) (ET-1) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-12378

BQ-123 3 Publications Verification	Endothelin Receptor	Cardiovascular Disease
BQ-123 is a potent and selective *endothelin A (ETA) receptor* antagonist with an IC₅₀ of 7.3 nM and a K_i of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .

HY-P1380A

Difopein TFA	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein TFA is a 14-3-3 protein inhibitor. Difopein TFA acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates Bcl-2, upregulates Bax, activates caspase-9 and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein TFA serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein TFA is applicable to glioma-related research .

HY-P1039A

R18 TFA PHCVPRDLSWLDLEANMCLP TFA	Raf	Cancer
R18 TFA is a peptide antagonists of *14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3* to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1 .

HY-P0202A

Endothelin 1 (swine, human) TFA Maximum Cited Publications 8 Publications Verification ET-1 (swine, human) TFA	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human) (ET-1) TFA is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 TFA acts through two types of receptors ET_A and ET_B .

HY-P1112

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an *ET_A/ET_B* selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P2496

Endothelin 1 (swine, human), Alexa Fluor 488-labeled	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of *ETA/ETB* receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-P1039

R18 PHCVPRDLSWLDLEANMCLP	Raf	Cancer
R18 is a peptide antagonists of *14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3* to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1 .

HY-P5885

PKCη pseudosubstrate inhibitor,myristoylated	PKC	Others
PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of PKCη .

HY-105183

PD 145065	Endothelin Receptor	Others
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC₅₀ value of 4 nM for the ET_A receptor for rabbit renal artery vascular smooth muscle cells .

HY-P1433

[Pro3]-GIP (Rat)	Insulin Receptor	Metabolic Disease
[Pro3]-GIP (Rat) is a selective GIP receptor partial agonist with a K_i of 13 nM. [Pro3]-GIP (Rat) can be used in diabetes research .

HY-P3228

JKC 302	Endothelin Receptor	Cardiovascular Disease
JKC 302 is an ET-A receptor antagonist. JKC 302 partly blocks ET-1-induced contraction in asthmatic rat trachea ring .

HY-P10151

PD 156252	Endothelin Receptor	Cardiovascular Disease
PD 156252 is a hexapeptide that is a highly potent endothelin (ET) antagonist. PD 156252 has enhanced binding affinity for rabbit ETA and rat ETB receptor subtypes with IC50 values of 1.0 and 40 nM, respectively.

HY-P1112A

Sarafotoxin S6a TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an *ET_A/ET_B* selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P1380

Difopein	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein is a 14-3-3 protein inhibitor. Difopein acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates Bcl-2, upregulates Bax, activates caspase-9 and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein is applicable to glioma-related research .

製品番号	製品名	Category	Target	構造式

HY-18980

Rottlerin 20+ Cited Publications Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Source Classification Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-122815

Fusicoccin Fusicoccin A	Microorganisms Classification of Application Fields Terpenoids Diterpenoids Disease Research Fields Source Classification Cancer	Apoptosis
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific *14-3-3* protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-N1433

Phytolaccagenin	Triterpenes Classification of Application Fields Terpenoids Phytolacca acinosa Roxb. Plants Inflammation/Immunology Disease Research Fields Phytolaccaceae Source Classification	Bacterial
Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae. Phytolcaccagenin has antifungal activity, anti-inflammatory activity and lower toxicity

HY-121197

Balanol Ophiocordin; Azepinostatin	Structural Classification 天然物 Microorganisms Source Classification	MARCKS PKA PKC
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC₅₀s=4-9 nM) and ζ (IC₅₀=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides .

HY-N13798

ADHPE	Zingiber officinale Roscoe Phenols Polyphenols Plants Source Classification Zingiberaceae	NF-κB Biochemical Assay Reagents
ADHPE is a stabilizer of 14-3-3σ and p65 protein complex. ADHPE inhibits NF-κB (p65) signaling pathway and reduces the inflammatory response. ADHPE can be used for pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome study .

HY-N1433R

Phytolaccagenin (Standard)	Triterpenes Structural Classification Terpenoids Phytolacca acinosa Roxb. Plants Phytolaccaceae Source Classification	Reference Standards Bacterial
Phytolaccagenin (Standard) is the analytical standard of Phytolaccagenin. This product is intended for research and analytical applications. Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae. Phytolcaccagenin has antifungal activity, anti-inflammatory activity and lower toxicity

HY-N5170

Aselacin A	天然物 Microorganisms Source Classification	Endothelin Receptor
Aselacin A targets endothelin-1 receptor (ET-1 receptor), inhibits the the binding of ET-1 to ETA receptor and ETB receptor. Aselacin A inhibits the ET-1 binding to bovine atrial membrane and porcine cerebral membrane with IC₅₀ of 22 μg/mL and 20 μg/mL. Aselacin A can be used for research of cardiovascular diseases .

HY-N19296

Blapsin B	Structural Classification Animals Phenols Polyphenols Source Classification	Drug Derivative
Blapsin B is a potent *14-3-3* inhibitor and a naturally occurring compound from Blaps japanensis. Blapsin B potently inhibits 14-3-3 protein-protein interactions (PPIs) with an IC₅₀ value of 10.0 μM in the ELISA assay and 2.5 μM in the FP assay, respectively. Blapsin B modulates signaling pathways involved in cell proliferation and transformation. Blapsin B can be used for cancer research .

HY-N14143

Citreamicin η	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Citreamicin η has anti-Gram-positive aerobic and anaerobic bacterial activities .

Species:	Human (20) Mouse (10) Cynomolgus (2)
Tag:	SUMO (1) His (17) Tag Free (9) Avi (1) Myc (1) GST (6)
Source:	HEK293 (4) E. coli Cell-free (1) P. pastoris (4) Sf9 insect cells (4) E. coli (19)

製品番号	Compare	製品名	Species	Source	Image

HY-P71682

	14-3-3 eta Protein, Human (GST) 14-3-3 protein eta; Brain protein 14-3-3; eta isoform; HGNC:12853; Protein AS1; YWHA 1; YWHA1; YWHAH	Human	E. coli
	YWHAH proteins are adapter proteins in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and regulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity and interacts with nuclear hormone receptors (AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP, THRA) and cofactors. 14-3-3 eta Protein, Human (GST) is the recombinant human-derived YWHAH protein, expressed by E. coli , with N-GST labeled tag.

HY-P703012

	14-3-3 theta Protein, Mouse (sf9, His) 14-3-3 protein theta; 14-3-3 protein tau; Ywhaq	Mouse	Sf9 insect cells
	14-3-3 theta Protein, Mouse (sf9, His) is the recombinant mouse-derived 14-3-3 theta protein, expressed by Sf9 insect cells, with His tag.

HY-P75548A

	14-3-3 theta Protein, Human (His) 14-3-3 protein theta; 14-3-3 protein tau; Protein HS1; YWHAQ	Human	E. coli
	14-3-3 theta proteins are adapters in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and modulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity, forms homodimers, and interacts with CDK16, phosphorylated RGS7, SSH1, phosphorylated CDKN1B, GAB2, phosphorylated PDPK1, and phosphorylated DAPK2. 14-3-3 theta Protein, Human (His) is the recombinant human-derived 14-3-3 theta protein, expressed by E. coli , with N-6His labeled tag.

HY-P75548

	14-3-3 theta Protein, Human (GST) 14-3-3 protein theta; 14-3-3 protein tau; Protein HS1; YWHAQ	Human	E. coli
	14-3-3 theta proteins are adapters in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and modulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity, forms homodimers, and interacts with CDK16, phosphorylated RGS7, SSH1, phosphorylated CDKN1B, GAB2, phosphorylated PDPK1, and phosphorylated DAPK2. 14-3-3 theta Protein, Human (GST) is the recombinant human-derived 14-3-3 theta protein, expressed by E. coli , with N-GST labeled tag.

HY-P75549

	14-3-3 epsilon Protein, Mouse (His) 14-3-3 protein epsilon, N-GST; YWHAE; 14-3-3E	Mouse	E. coli
	14-3-3 epsilon proteins are adapter proteins in various signaling pathways that bind to phosphoserine or phosphothreonine motifs to regulate chaperone activity.It positively regulates HSF1 nuclear export to the cytoplasm, forming homo- and heterodimers with YWHAZ.14-3-3 epsilon Protein, Mouse (His) is the recombinant mouse-derived 14-3-3 epsilon protein, expressed by E.coli , with N-6*His labeled tag.

HY-P74438

	14-3-3 sigma Protein, Mouse 14-3-3 protein sigma; HME1; SFN; Stratifin; Mkrn3	Mouse	E. coli
	14-3-3 sigma proteins are adapter proteins in various signaling pathways that bind to phosphoserine or phosphothreonine motifs to regulate chaperone activity. When bound to KRT17, it stimulates the regulation of protein synthesis and cell growth through the Akt/mTOR pathway. 14-3-3 sigma Protein, Mouse is the recombinant mouse-derived 14-3-3 sigma protein, expressed by E. coli , with tag free.

HY-P702997

	14-3-3 zeta Protein, Human 14-3-3 zeta; YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156	Human	E. coli
	14-3-3 zeta Protein, Human is the recombinant human-derived 14-3-3 zeta, expressed by E. coli, with tag free labeled tag.

HY-P74440

	14-3-3 beta Protein, Human KCIP-1; 14-3-3 protein beta/alpha; GW128; Protein 1054; YWHAB	Human	E. coli
	14-3-3 beta proteins serve as adapter proteins that regulate multiple signaling pathways by recognizing phosphoserine or phosphothreonine motifs and regulating chaperone activity. It acts as a negative regulator during osteogenesis, inhibiting nuclear translocation of SRPK2 and preventing neuronal apoptosis. 14-3-3 beta Protein, Human is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli , with tag free.

HY-P75550

	14-3-3 beta Protein, Cynomolgus KCIP-1; 14-3-3 protein beta/alpha; GW128; Protein 1054; YWHAB	Cynomolgus	E. coli
	14-3-3 beta proteins act as adapters, binding to phosphoserine or phosphothreonine motifs in different signaling pathways, regulating chaperone activity. It negatively regulates osteogenesis by blocking the nuclear translocation of phosphorylated SRPK2 and counteracting the pro-apoptotic effect of SRPK2 through cyclin D1 expression. 14-3-3 beta Protein, Cynomolgus is the recombinant cynomolgus-derived 14-3-3 beta protein, expressed by E. coli , with tag free.

HY-P702996

	14-3-3 zeta Protein, Human (sf9, His) 14-3-3 zeta; YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156	Human	Sf9 insect cells
	14-3-3 zeta Protein, Human (sf9, His) is the recombinant human-derived 14-3-3 zeta, expressed by Sf9 insect cells, with His labeled tag.

HY-P700304

	14-3-3 beta Protein, Human (His) KCIP-1; 14-3-3 protein beta/alpha; GW128; Protein 1054; YWHAB	Human	E. coli
	14-3-3 beta proteins serve as adapter proteins that regulate multiple signaling pathways by recognizing phosphoserine or phosphothreonine motifs and regulating chaperone activity. It acts as a negative regulator during osteogenesis, inhibiting nuclear translocation of SRPK2 and preventing neuronal apoptosis. 14-3-3 beta Protein, Human (His) is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74439

	14-3-3 beta Protein, Human (GST) KCIP-1; 14-3-3 protein beta/alpha; GW128; Protein 1054; YWHAB	Human	E. coli
	14-3-3 beta proteins serve as adapter proteins that regulate multiple signaling pathways by recognizing phosphoserine or phosphothreonine motifs and regulating chaperone activity. It acts as a negative regulator during osteogenesis, inhibiting nuclear translocation of SRPK2 and preventing neuronal apoptosis. 14-3-3 beta Protein, Human (GST) is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli , with N-GST labeled tag.

HY-P703013

	14-3-3 zeta Protein, Mouse (sf9, His) 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1 (KCIP-1); SEZ-2; Ywhaz	Mouse	Sf9 insect cells
	14-3-3 zeta Protein, Mouse (sf9, His) is the recombinant mouse-derived 14-3-3 zeta, expressed by Sf9 insect cells, with His labeled tag.

HY-P7445

	14-3-3 epsilon Protein, Human (GST) rHu14-3-3 protein epsilon, N-GST; YWHAE	Human	E. coli
	14-3-3 epsilon Protein, Human (GST) is a mediator that guides chondrocytes toward an inflammatory phenotype with GST tag.

HY-P702995

	14-3-3 zeta Protein, Human (GST) Proto-oncogene vav; VAV1; VAV	Human	E. coli
	14-3-3 zeta Protein, Human (GST) is the recombinant human-derived 14-3-3 zeta, expressed by E. coli, with GST labeled tag.

HY-P71339

	Stratifin Protein, Human 1 Publications Verification 14-3-3 Protein Sigma; Epithelial Cell Marker Protein 1; Stratifin; SFN; HME1	Human	E. coli
	Stratifin (14-3-3 sigma), encoded by SFN, functions as a multifaceted adapter protein that binds to partners through phosphoserine or phosphothreonine motifs and participates in a variety of cellular processes. It regulates epithelial cell growth and protein synthesis through keratin 17 (KRT17), and may affect MDM2 autoubiquitination and activate p53. Stratifin Protein, Human is the recombinant mouse-derived Stratifin protein, expressed by E. coli , with tag free.

HY-P700308

	Stratifin Protein, Human (N-His, C-Myc) 14-3-3 Protein Sigma; Epithelial Cell Marker Protein 1; Stratifin; SFN; HME1	Human	E. coli
	Stratifin (14-3-3 sigma), encoded by SFN, functions as a multifaceted adapter protein that binds to partners through phosphoserine or phosphothreonine motifs and participates in a variety of cellular processes. It regulates epithelial cell growth and protein synthesis through keratin 17 (KRT17), and may affect MDM2 autoubiquitination and activate p53. Stratifin Protein, Human (N-His, C-Myc) is the recombinant human-derived Stratifin protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P71850

	KCIP-1 Protein, Mouse (P.pastoris, His) Ywhab; 14-3-3 protein beta/alpha; Protein kinase C inhibitor protein 1; KCIP-1	Mouse	P. pastoris
	KCIP-1 protein serves as the linker of TNFRSF1A/TNFR1 and mediates its interaction with FADD. Overexpression induces TNF-induced responses: apoptosis and NF-κ-B activation. KCIP-1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived KCIP-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71850Y

	KCIP-1 Protein, Mouse (P.pastoris, His, solution) Ywhab; 14-3-3 protein beta/alpha; Protein kinase C inhibitor protein 1; KCIP-1	Mouse	P. pastoris
	KCIP-1 protein serves as the linker of TNFRSF1A/TNFR1 and mediates its interaction with FADD. Overexpression induces TNF-induced responses: apoptosis and NF-κ-B activation. KCIP-1 Protein, Mouse (P.pastoris, His, solution) is the recombinant mouse-derived KCIP-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71730

	EDNRA Protein, Human (P.pastoris, His) Ednra; ET A; ET-A; eta; eta R; eta-R; etaR; ETRA; G protein coupled receptor; hET AR; hET-AR; MFDA	Human	P. pastoris
	EDNRA Protein, a receptor for endothelin-1, activates a phosphatidylinositol-calcium second messenger system through association with G proteins. Its binding affinities follow the order: ET1 > ET2 >> ET3. Additionally, EDNRA interacts with HDAC7 and KAT5. EDNRA Protein, Human (P.pastoris, His) is the recombinant human-derived EDNRA protein, expressed by P. pastoris , with N-His labeled tag.

HY-P704570

	EDNRA Protein-VLP, Human (HEK293) Ednra; ET A; ET-A; eta; eta R; eta-R; etaR; ETRA; G protein coupled receptor; hET AR; hET-AR; MFDA	Human	HEK293
	EDNRA Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P704116

	EDNRA Protein, Human (Cell-Free, C-His) Ednra; ET A; ET-A; eta; eta R; eta-R; etaR; ETRA; G protein coupled receptor; hET AR; hET-AR; MFDA	Human	E. coli Cell-free
	EDNRA Protein, a receptor for endothelin-1, activates a phosphatidylinositol-calcium second messenger system through association with G proteins. Its binding affinities follow the order: ET1 > ET2 >> ET3. Additionally, EDNRA interacts with HDAC7 and KAT5. EDNRA Protein, Human (Cell-Free, C-His) is the recombinant human-derived EDNRA protein, expressed by E. coli Cell-free, with C-10*His labeled tag.

HY-P702643

	PRKCH Protein, Human (Active, sf9, GST) PKCL; PKC-L; PRKCL; nPKC-eta; protein kinase C eta type	Human	Sf9 insect cells
	PRKCH Protein, Human (sf9, GST) is the recombinant human-derived PRKCH, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P74200

	DEP-1/CD148 Protein, Human (341a.a, His) Receptor-type tyrosine-protein phosphatase eta; R-PTP-eta; DEP-1; CD148; PTPRJ	Human	E. coli
	DEP-1/CD148 protein is a tyrosine phosphatase that affects multiple targets such as CTNND1, FLT3, PDGFRB, and EGFR, thereby affecting cellular processes such as adhesion, migration, proliferation, and differentiation. DEP-1/CD148 is critical in vascular development, regulating macrophage adhesion, platelet activation, and thrombosis, while negatively regulating cell proliferation and PDGF-stimulated migration. DEP-1/CD148 Protein, Human (341a.a, His) is the recombinant human-derived DEP-1/CD148 protein, expressed by E. coli , with N-His labeled tag.

HY-P71862

	IL-36 beta/IL-1F8 Protein, Human (153a.a) Family of interleukin 1 eta; FIL1 eta; ; FIL1; FIL1 eta; FIL1H; FILI-eta; ; IL 1F8 FIL1 eta; IL 1F8; IL 1H2; IL-1 eta; IL-1F8; IL-1H2; IL1 eta; IL1F8 Canonical product IL 1F8a; ; IL1F8; IL1F8_HUMAN; IL1H2; IL36 beta; IL36B; Interleukin 1 family, member 8 eta; ; Interleukin 1 family, member 8; Interleukin 1 homolog 2; Interleukin 1 Superfamily e; Interleukin 36 beta; Interleukin-1 eta; Interleukin-1 family member 8; Interleukin-1 homolog 2; MGC126880; MGC126882; OTTMUSP00000012797; RP23-176J12.1	Human	E. coli
	IL-36 beta/IL-1F8 protein signals through IL-36R, activates NF-kappa-B and MAPK pathways, and induces pro-inflammatory responses. It is present in the epithelial barrier and shares the IL-1 system coreceptor IL1RAP. IL-36 beta/IL-1F8 Protein, Human (153a.a) is the recombinant human-derived IL-36 beta/IL-1F8 protein, expressed by E. coli , with tag free. The total length of IL-36 beta/IL-1F8 Protein, Human (153a.a) is 153 a.a., with molecular weight of ~ 17.2 kDa.

HY-P72546

	IL-36 beta/IL-1F8 Protein, Mouse Interleukin-36 beta; FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; IL36B	Mouse	E. coli
	IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Mouse is a recombinant mouse IL-36 beta without any tag, which is produced in E. coli.

HY-P72545

	IL-36 beta/IL-1F8 Protein, Human Interleukin-36 beta; FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; IL36B	Human	E. coli
	IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Human is a recombinant human IL-36 beta without any tag, which is produced in E. coli.

HY-P705067

	Osteopontin/OPN Protein, Mouse (Biotinylated, HEK293, His-Avi) SPP1; BNSP; OPN; Uropontin; Nephropontin; Osteopontin; BSP-1; eta-1; BSPI	Mouse	HEK293

HY-P71786

	Osteopontin/OPN Protein, Mouse (P.pastoris, His) 3 Publications Verification Spp1; eta-1; Op; Spp-1; Osteopontin; 2AR; Minopontin; Secreted phosphoprotein 1; SPP-1	Mouse	P. pastoris
	Osteopontin/OPN Protein, a crucial non-collagenous bone protein, binds strongly to hydroxyapatite, integral to the mineralized matrix.It likely plays a vital role in mediating cell-extracellular matrix interactions.Moreover, as a cytokine, OPN efficiently induces interferon-gamma and interleukin-12 production while inhibiting interleukin-10, pivotal in promoting type I immunity.Osteopontin/OPN Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Osteopontin/OPN protein, expressed by P.pastoris , with N-6*His labeled tag.

HY-P78358

	Osteopontin/OPN Protein, Mouse (HEK293, His) 4 Publications Verification Osteopontin; Bone sialoprotein 1; Nephropontin; SPP-1; BNSP; OPN; SPP1; Uropontin; BSP-1; eta-1; BSPI	Mouse	HEK293
	Osteopontin/OPN Protein, a crucial non-collagenous bone protein, binds strongly to hydroxyapatite, integral to the mineralized matrix.It likely plays a vital role in mediating cell-extracellular matrix interactions.Moreover, as a cytokine, OPN efficiently induces interferon-gamma and interleukin-12 production while inhibiting interleukin-10, pivotal in promoting type I immunity.Osteopontin/OPN Protein, Mouse (HEK293, His) is the recombinant mouse-derived Osteopontin/OPN protein, expressed by HEK293 , with C-His labeled tag.

HY-P701071

	Osteopontin/OPN Protein, Cynomolgus (HEK293, His) Secreted phosphoprotein 1; Osteopontin; Bone sialoprotein 1; Nephropontin; SPP-1; BNSP; OPN; SPP1; Uropontin; BSP-1; eta-1; BSPI	Cynomolgus	HEK293
	Osteopontin/OPN protein is an important member of the osteopontin family and plays a key role in cell adhesion, immune response regulation, and tissue mineralization. Osteopontin has conserved features within the family and its multifunctional properties contribute to both homeostasis and pathological conditions. Osteopontin/OPN Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Osteopontin/OPN protein, expressed by HEK293 , with C-His labeled tag.

HY-P72226

	HJURP Protein, Human (His-SUMO) HJURP; FAKTS; FLEG1; URLC9; Holliday junction recognition protein; 14-3-3-associated AKT substrate; Fetal liver-expressing gene 1 protein; Up-regulated in lung cancer 9	Human	E. coli
	The HJURP protein is a centromeric factor that plays a critical role in centromeric integration and maintenance of CENPA. As a chaperone, it ensures the integration of newly synthesized CENPA into nucleosomes at replicating centromeres. HJURP Protein, Human (His-SUMO) is the recombinant human-derived HJURP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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製品番号	製品名	構造式

HY-15895S

Aprocitentan-d4
Aprocitentan-d₄ is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent .

HY-14184S

Macitentan-d4
Macitentan-d₄ is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

HY-B1433S

Perindoprilat-d3 disodium
Perindoprilat-d₃ disodium is deuterated labeled Perindoprilat (HY-B1433). Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC₅₀ value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research .

HY-105829S

Sulfatroxazole-d4
Sulfatroxazole-d₄ (Isosulfafurazole-d₄) is the deuterium labeled Sulfatroxazole (HY-105829) . Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of ETA receptor (IC₅₀ of 0.26 μM) .

HY-76520S

Sitaxsentan-13C6

Sitaxsentan- ¹³C₆ (IPI 1040- ¹³C₆) is ¹³C labeled Sitaxsentan (HY-76520). Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC₅₀ of 1.4 nM and a K_i of 0.43 nM. Sitaxsentan exhibits an IC₅₀ for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .

Host:	Mouse (13) Rabbit (22)
Reactivity:	Human (35) Rat (27) Mouse (26) Monkey (2) Cow (2)
Application:	IHC-P (20) ICC/IF (12) mIHC (1) IF-Tissue (5) IP (5) IHC-F (4) WB (31) FC (9) ELISA (8)
Isotype:	IgG, Kappa (1) IgG (25) IgG1 (5) IgG2b (3)
Conjugation:	Non-conjugated (35) Biotin (1)
Clonality:	Monoclonal (17) Monoclonal Antibody (2) Recombinant (11)
Modification:	Unmodified (19)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P85780

	14-3-3 eta Antibody (YA5472) 14-3-3 protein eta; Protein AS1;	WB, IHC-P	Human, Mouse, Rat
	14-3-3 eta Antibody (YA5472) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to 14-3-3 eta.

HY-P80525

	14-3-3 eta Antibody (YA838) 14-3-3 protein eta; 1433F_HUMAN; Brain protein 14-3-3; eta isoform; HGNC:12853; Protein AS1; Tyrosine 3/tryptophan 5 monooxygenase activation protein eta polypeptide; YWHA 1; YWHA1; YWHAH.	WB	Human, Mouse, Rat
	14-3-3 eta Antibody (YA838) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 eta.

HY-P80525A

	14-3-3 eta Antibody (YA838)(PBS only) 14-3-3 protein eta; 1433F_HUMAN; Brain protein 14-3-3; eta isoform; HGNC:12853; Protein AS1; Tyrosine 3/tryptophan 5 monooxygenase activation protein eta polypeptide; YWHA 1; YWHA1; YWHAH.	WB	Human, Mouse, Rat
	14-3-3 eta Antibody (YA838) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 eta.

HY-P82210

	14-3-3 theta Antibody (YA1955) YWHAQ; 14-3-3 protein theta; 14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1	WB	Human, Mouse, Rat
	14-3-3 theta Antibody (YA1955) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 theta.

HY-P82210A

	14-3-3 theta Antibody (YA1955)(PBS only) YWHAQ; 14-3-3 protein theta; 14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1	WB	Human, Mouse, Rat
	14-3-3 theta Antibody (YA1955) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 theta.

HY-P84223

	14-3-3 theta Antibody (YA3920) 1C5; HS1; 14-3-3	WB, ELISA	Human, Mouse, Rat, Monkey
	14-3-3 theta Antibody (YA3920) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to 14-3-3 theta.

HY-P84223A

	14-3-3 theta Antibody (YA3920)(PBS only) 1C5; HS1; 14-3-3	WB, ELISA	Human, Mouse, Rat, Monkey
	14-3-3 theta Antibody (YA3920) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to 14-3-3 theta.

HY-P87613

	14-3-3 gamma Antibody (YA7297)	WB, FC	Human, Mouse, Rat
	14-3-3 gamma Antibody (YA7297) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 gamma.

HY-P87937

	14-3-3 ε Antibody (YA7622)	WB, ICC/IF, ELISA	Human, Mouse, Rat
	14-3-3 ε Antibody (YA7622) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to 14-3-3 ε.

HY-P810942

	14-3-3 zeta Antibody 14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	14-3-3 zeta Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to 14-3-3 zeta.

HY-P82884

	14-3-3 epsilon Antibody (YA2629) 14-3-3 epsilon; 14-3-3E; 143E; KCIP-1; MDCR; Protein kinase C inhibitor protein-1; YWHAE	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	14-3-3 epsilon Antibody (YA2629) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 epsilon.

HY-P82909

	14-3-3 sigma Antibody (YA2654) SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin	WB, IHC-P	Human, Rat
	14-3-3 sigma Antibody (YA2654) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 sigma.

HY-P82923

	14-3-3 gamma Antibody (YA2668) YWHAG; 14-3-3 protein gamma; Protein kinase C inhibitor protein 1; KCIP-1	WB	Human, Mouse, Rat
	14-3-3 gamma Antibody (YA2668) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 gamma.

HY-P82923A

	14-3-3 gamma Antibody (YA2668)(PBS only) YWHAG; 14-3-3 protein gamma; Protein kinase C inhibitor protein 1; KCIP-1	WB	Human, Mouse, Rat
	14-3-3 gamma Antibody (YA2668) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 gamma.

HY-P82204

	14-3-3 beta Antibody (YA1949) YWHAB; 14-3-3 protein beta/alpha; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1	WB	Human, Rat
	14-3-3 beta Antibody (YA1949) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 beta.

HY-P810943

	14-3-3 zeta/ Protein kinase C inhibitor protein 1 Antibody 14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	14-3-3 zeta/ Protein kinase C inhibitor protein 1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to 14-3-3 zeta.

HY-P84258

	14-3-3 beta Antibody (YA3955) HS1; GW128; YWHAA; KCIP-1; HEL-S-1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	14-3-3 beta Antibody (YA3955) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to 14-3-3 beta.

HY-P810941

	*Phospho-14-3-3* zeta (Ser58) Antibody** 14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-14-3-3 zeta (Ser58) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Phospho-14-3-3 zeta (Ser58).

HY-P811126

	*Phospho-14-3-3* zeta (Thr232) Antibody** 14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ	WB, IHC-P	Human, Mouse, Rat
	Phospho-14-3-3 zeta (Thr232) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Phospho-14-3-3 zeta (Thr232).

HY-P84258A

	14-3-3 beta Antibody (YA3955)(PBS only) HS1; GW128; YWHAA; KCIP-1; HEL-S-1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	14-3-3 beta Antibody (YA3955) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to 14-3-3 beta.

HY-P811027

	Protein kinase C inhibitor protein 1 Antibody 14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	14-3-3 zeta/ Protein kinase C inhibitor protein 1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to 14-3-3 zeta.

HY-P80869

	*PKC eta* Antibody (YA126)** nPKC eta; PKC h; PKC L; PKCh; PKCL; Prkch; PRKCL; Protein kinase C eta	WB, IP	Human, Mouse, Rat
	PKC eta Antibody (YA126) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC eta.

HY-P80869A

	*PKC eta* Antibody (YA126)(PBS only)** nPKC eta; PKC h; PKC L; PKCh; PKCL; Prkch; PRKCL; Protein kinase C eta	WB, IP	Human, Mouse, Rat
	PKC eta Antibody (YA126) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC eta.

HY-P811187

	Endothelin A Receptor Antibody eta, ETRA, EDNRA, Endothelin-1 receptor, Endothelin receptor type A, ET-A, eta-R, hET-AR	WB, ICC/IF	Human, Mouse
	Endothelin A Receptor Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Endothelin A Receptor.

HY-P87416A

	DEP1/CD148 Antibody (YA7104)(PBS only) CD148, DEP1, PTPRJ, Receptor-type tyrosine-protein phosphatase eta, Protein-tyrosine phosphatase eta, R-PTP-eta, Density-enhanced phosphatase 1, HPTP eta, Protein-tyrosine phosphatase receptor type J, DEP-1, R-PTP-J	FC, ELISA	Human
	DEP1/CD148 Antibody (YA7104) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DEP1/CD148.

HY-P84046

	Osteopontin Antibody (YA3743) OPN; BNSP; BSPI; eta-1	IHC-P, ELISA	Human
	Osteopontin Antibody (YA3743) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Osteopontin.

HY-P84046A

	Osteopontin Antibody (YA3743)(PBS only) OPN; BNSP; BSPI; eta-1	IHC-P, ELISA	Human
	Osteopontin Antibody (YA3743) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Osteopontin.

HY-P81688

	TARBP2 Antibody (YA1433) LOQS; Prbp; tarbp2; TRBP; TRBP1; TRBP2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	TARBP2 Antibody (YA1433) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TARBP2.

HY-P86735

	Transferrin Antibody (YA6427) Apotransferrin; TRF; eta 1 metal binding globulin; DKFZp781D0156; PRO1400; PRO1557; PRO2086; Serotransferrin precursor; Siderophilin; TF; TRFE_HUMAN; beta-1 metal-binding globulin; Serotransferrin.	WB, IHC-P, IHC-F, IF-Tissue, FC	Human, Rat, Mouse, Cow
	Transferrin Antibody (YA6427) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Transferrin.

HY-P86735A

	Transferrin Antibody (YA6427)(PBS only) Apotransferrin; TRF; eta 1 metal binding globulin; DKFZp781D0156; PRO1400; PRO1557; PRO2086; Serotransferrin precursor; Siderophilin; TF; TRFE_HUMAN; beta-1 metal-binding globulin; Serotransferrin.	WB, IHC-P, IHC-F, IF-Tissue, FC	Human, Rat, Mouse, Cow
	Transferrin Antibody (YA6427) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Transferrin.

HY-P88372

	DNA polymerase iota Antibody (YA8056) polymerase (DNA) iota, eta2, RAD3OB, RAD30B	IHC-P	Human
	POLI Antibody (YA8056) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to POLI.

HY-P86670

	Osteopontin Antibody (YA6362) BNSP; Bone sialoprotein 1; BSP I; BSPI; Early T lymphocyte activation 1; eta 1; eta1; MGC110940; Nephropontin; OPN; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; OSTP_HUMAN; secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); Secreted phosphoprotein 1; SPP 1; SPP-1; SPP1; SPP1/CALPHA1 fusion; Urinary stone protein; Uropontin.	IHC-P, WB, IHC-F, IF-Tissue	Human
	Osteopontin Antibody (YA6362) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Osteopontin.

HY-P86670A

	Osteopontin Antibody (YA6362)(PBS only) BNSP; Bone sialoprotein 1; BSP I; BSPI; Early T lymphocyte activation 1; eta 1; eta1; MGC110940; Nephropontin; OPN; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; OSTP_HUMAN; secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); Secreted phosphoprotein 1; SPP 1; SPP-1; SPP1; SPP1/CALPHA1 fusion; Urinary stone protein; Uropontin.	IHC-P, WB, IHC-F, IF-Tissue	Human
	Osteopontin Antibody (YA6362) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Osteopontin.

HY-P810729

	Osteopontin Antibody (YA9973) eta-1, Op, Spp-1, Spp1, Osteopontin, 2AR, Bone sialoprotein 1, Calcium oxalate crystal growth inhibitor protein, Early T-lymphocyte activation 1 protein, Minopontin, Secreted phosphoprotein 1, SPP-1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Osteopontin Antibody (YA9973) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to Osteopontin Antibody.

HY-P86804

	CD3 epsilon Antibody (YA6497) 1 Publications Verification 4930549J05Rik antibody; A430104F18Rik antibody; AW552088 antibody; Cd247 antibody; CD3 antibody; CD3 delta antibody; CD3 epsilon antibody; CD3 eta antibody; CD3 gamma antibody; CD3 zeta antibody; CD3H antibody; CD3Q antibody; CD3Z antibody; CD3zeta antibody; Ctg3 antibody; FLJ17620 antibody; FLJ17664 antibody; FLJ18683 antibody; FLJ79544 antibody FLJ94613 antibody; IMD19 antibody; Leu-4 antibody; MGC138597 antibody; OKT3, delta chain antibody; OTTHUMP00000032544 antibody; T cell receptor antibody; T3 antibody; T3d antibody; T3e antibody; T3g antibody; T3z antibody; TCRE antibody; TCRk antibody; Tcrz antibody; TCRzeta antibody	WB, IHC-P, ICC/IF, IP, IF-Tissue, mIHC	Human
	CD3 epsilon Antibody (YA6497) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD3 epsilon.

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製品番号	製品名		Classification

HY-W011725

N-6-Methyl-2-deoxyadenosine m6dA		Nucleoside Analogs Adenosine
N-6-Methyl-2-deoxyadenosine (m6dA) is an adenine nucleoside analogue. N-6-Methyl-2-deoxyadenosine targets nuclear processes and DNA replication machineries including WER, SATB1, TFAM, Jumu, SSBP1, DNA polymerase η and phage polymerase Gp90 exo ⁻. N-6-Methyl-2-deoxyadenosine acts as a multifunctional epigenetic regulator that modulates transcription, DNA damage response, cell cycle, transposon silencing, stress adaptation, epigenetic crosstalk, and nucleosome organization in both prokaryotes and eukaryotes. N-6-Methyl-2-deoxyadenosine regulates mitochondrial epigenetic inheritance and is required for fear extinction memory in mice. N-6-Methyl-2-deoxyadenosine exhibits dysregulated levels in cancers. N-6-Methyl-2-deoxyadenosine can be used for the research of glioblastoma, triple negative breast cancer, and conditioned fear (fear extinction impairment) .

HY-R00278

*hsa-miR-143-3p mimic*		MicroRNAs miRNA mimics
hsa-miR-143-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RS15943

YWHAH Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
YWHAH Human Pre-designed siRNA Set A contains three designed siRNAs for YWHAH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19495

Ywhah Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ywhah Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ywhah gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS25989

Ywhah Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ywhah Rat Pre-designed siRNA Set A contains three designed siRNAs for Ywhah gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-R04234

*rno-miR-143-3p mimic*		MicroRNAs miRNA mimics
rno-miR-143-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI00278

*hsa-miR-143-3p inhibitor*		MicroRNAs miRNA inhibitors
hsa-miR-143-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R00278A

*hsa-miR-143-3p agomir*		MicroRNAs miRNA agomirs
hsa-miR-143-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI04234

*rno-miR-143-3p inhibitor*		MicroRNAs miRNA inhibitors
rno-miR-143-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R04234A

*rno-miR-143-3p agomir*		MicroRNAs miRNA agomirs
rno-miR-143-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI00278A

*hsa-miR-143-3p antagomir*		MicroRNAs miRNA antagomirs
hsa-miR-143-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI04234A

*rno-miR-143-3p antagomir*		MicroRNAs miRNA antagomirs
rno-miR-143-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

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