Nerve Growth Factor 2.5S,murine submaxillary gland
Nerve Growth Factor 2.5S,murine submaxillary gland is a neurotrophic polypeptide and protein growth factor isolated from murine submaxillary glands. Nerve Growth Factor 2.5S,murine submaxillary gland increases the survival rate, phagocytic capacity and superoxide anion production level of mouse cells. Nerve Growth Factor 2.5S,murine submaxillary gland acts through cell membrane surface receptors to mediate the differentiation and maintenance of adrenergic neurons in the sympathetic nervous system. Nerve Growth Factor 2.5S,murine submaxillary gland loses its activity and undergoes dimer dissociation due to oxidation; it remains active after modification of specific tryptophan residues, while its tyrosine residues are not essential for activity. Nerve Growth Factor 2.5S,murine submaxillary gland may play a role in the inflammatory process.
For research use only. We do not sell to patients.
- CAS No.: 93928-24-6
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Biological Activity
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Chemical Information
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Biological Activity
Description
In Vitro
2.5S nerve growth factor (0.5-500 ng/mL; 1-6 days) dose-dependently increases the survival rate of neutrophils in mouse peripheral blood and peritoneal cavity: at a concentration of 50 ng/mL, the survival rate of blood neutrophils reaches 20% after 6 days of culture, and it significantly enhances the survival rate of peritoneal neutrophils at all tested time points[1].
2.5S nerve growth factor (0.5-500 ng/mL; 20 min) enhances the phagocytosis of hydrophilic microspheres by mouse peritoneal neutrophils, exhibits significant activity at 0.5 ng/mL, and reaches the maximum effect at 5 ng/mL[1].
2.5S nerve growth factor (50 ng/mL; 15-60 min preincubation) enhances superoxide anion production in mouse peritoneal neutrophils induced by PMA (HY-18739) and opsonized zymosan, with the peak activity observed after 30 minutes of preincubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 93928-24-6
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Appearance Solid
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Color White to light yellow
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SMILES
[Nerve Growth Factor 2.5S,murine submaxillary gland]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Kannan Y, et al. 2.5S nerve growth factor enhances survival, phagocytosis, and superoxide production of murine neutrophils. Blood. 1991 Mar 15;77(6):1320-5. [Content Brief]
[2]. Frazier WA, et al. Topography of mouse 2.5S nerve growth factor. Reactivity of tyrosine and tryptophan. Biochemistry. 1973 Aug 14;12(17):3281-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nerve Growth Factor 2.5S,murine submaxillary gland Related Classifications
HY-NP143 Related Classifications
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Keywords
- Nerve Growth Factor 2.5S,murine submaxillary gland
- 93928-24-6
- Reactive Oxygen Species (ROS)
- Adrenergic Receptor
- murine peripheral blood neutrophils
- tyrosine residues
- phagocytosis
- sympathetic nervous system adrenergic neurons
- murine neutrophils
- Swiss ICR mice
- superoxide production
- murine peritoneal neutrophils
- tryptophan residues
- surface membrane receptor
- Inhibitor
- inhibitor
- inhibit