1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Perindoprilat

Perindoprilat  (Synonyms: S 9780)

Cat. No.: HY-B1433
Handling Instructions

Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research.

For research use only. We do not sell to patients.

Perindoprilat Chemical Structure

Perindoprilat Chemical Structure

CAS No. : 95153-31-4

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Description

Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2].

In Vitro

Perindoprilat (1 μM, 10 days) treatment suppresses the angiotensin II production in HNSCC cells[2]. Perindoprilat (40 μM, 3 days) treatment attenuates mesangial cell fibronectin level[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: HNSCC cells
Concentration: 1 μM
Incubation Time: 10 days
Result: Suppressed the angiotensin II production in HNSCC cells (P=0.028).

Cell Viability Assay[3]

Cell Line: Human mesangial cells
Concentration: 40 μM
Incubation Time: 3 days
Result: Resulted in decreases in MPCM-stimulated fibronectin levels of 19.4±0.6% (P<0.001) and 21.7±1.0% (P<0.001) for secreted and cell-associated fibronectin levels, respectively.
In Vivo

Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment improves cardiac function in mice with acute myocardial infarction and reduces the number of apoptotic myocardial cells[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment reduces the expression levels of myocardial Bax and Bcl-2 in infarction zones of mice with acute myocardial infarction[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment lowers the expression of myocardial TLR4/NF-κB in infarction zones in mice with acute myocardial infarction[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice underwent coronary ligation[4]
Dosage: 1.5 mg/kg
Administration: Oral gavage; 1.5 mg/kg; once daily; 7 days
Result: Exhibited markedly lowered the number of apoptotic myocardial cells in comparison with the acute myocardial infarction group (p<0.05).
Animal Model: C57BL/6J mice underwent coronary ligation[4]
Dosage: 1.5 mg/kg
Administration: Oral gavage; 1.5 mg/kg; once daily; 7 days
Result: Reduced the gene and protein expression levels of Bax (a myocardial apoptosis gene) in infarction zones in mice with acute myocardial infarction.
Animal Model: C57BL/6J mice underwent coronary ligation[4]
Dosage: 1.5 mg/kg
Administration: Oral gavage; 1.5 mg/kg; once daily; 7 days
Result: Declined the number of stained NF-κB p50 protein in the nucleus in infarction zones (p<0.05), compared to the acute myocardial infarction group.
Molecular Weight

340.41

Formula

C17H28N2O5

CAS No.
SMILES

O=C([[email protected]]1N(C([[email protected]@H](N[[email protected]](C(O)=O)CCC)C)=O)[[email protected]@]2([H])CCCC[[email protected]@]2([H])C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Perindoprilat
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HY-B1433
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