2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Mevalonic acid lithium salt

Mevalonic acid lithium salt  (Synonyms: MVA lithium salt)

Cat. No.: HY-113071A Purity: 98.0%
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Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure.

For research use only. We do not sell to patients.

CAS No. : 2618458-93-6

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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Mevalonic acid lithium salt:

Mevalonic acid lithium salt Related Antibodies

Top Publications Citing Use of Products

    Mevalonic acid lithium salt purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11.  [Abstract]

    Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) significantly shortened activated partial thromboplastin time (APTT) and prothrombin time (PT) in C57BL/C mice.

    Mevalonic acid lithium salt purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11.  [Abstract]

    Mice were subjected to the inferior vena cava IVC stasis model for 5 h to evaluate venous thrombosis formation, with subsequent pathological assessment by hematoxylin and eosin (HE) staining. The results showed that Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) treatment markedly increased both thrombus weight.

    Mevalonic acid lithium salt purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11.  [Abstract]

    Mice were administered injections of either 500 ng/kg Mevalonic acid lithium salt (MVA). On 24 h after transient middle cerebral artery occlusion (tMCAO), typical images of coronal brain sections stained with 2,3,5-triphenyltetrazolium chloride (TTC). The results showed that MVA led to a significant increase in infarct volume.

    Mevalonic acid lithium salt purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Nov;42(11):1875-1887.  [Abstract]

    HCT116 and LoVo cells were cultured with lovastatin (15 μM) and 2DG (5 mM) alone or in combination for 72 h in either the presence or absence of 200 mM Mevalonate, and cell proliferation was determined. *P < 0.05, **P < 0.01. ##P < 0.01 vs corresponding Mevalonic acid lithium salt (MVA) (-) group.

    Mevalonic acid lithium salt purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2021 Oct 9;11(1):179.  [Abstract]

    Western blotting was used to assess changes in the expression of unphosphorylated YAP in HOS and MG63 cells following a 6 h Mevalonic acid lithium salt (Meva) treatment.

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    • Purity & Documentation

    • References

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    Description

    Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Mevalonic acid lithium salt (80, 90, 100, 110 μM; 72 h) shows prevention of simvastatin-induced loss of viability of C2C12myotube cells in vitro[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Mevalonic acid lithium salt Related Antibodies

    Cell Viability Assay[1]

    Cell Line: C2C12 cells (simvastatin-induced)
    Concentration: 80, 90, 100, 110 µM
    Incubation Time: 72 h
    Result: Showed no decline in cell viability.
    Clinical Trial
    Molecular Weight

    154.09

    Formula

    C6H11LiO4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[Li])CC(C)(O)CCO
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (648.97 mM; Need ultrasonic)

    DMSO : 50 mg/mL (324.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.4897 mL 32.4486 mL 64.8971 mL
    5 mM 1.2979 mL 6.4897 mL 12.9794 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (162.24 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.80%

    SDS (393 KB)

    COA (245 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 6.4897 mL 32.4486 mL 64.8971 mL 162.2428 mL
    5 mM 1.2979 mL 6.4897 mL 12.9794 mL 32.4486 mL
    10 mM 0.6490 mL 3.2449 mL 6.4897 mL 16.2243 mL
    15 mM 0.4326 mL 2.1632 mL 4.3265 mL 10.8162 mL
    20 mM 0.3245 mL 1.6224 mL 3.2449 mL 8.1121 mL
    25 mM 0.2596 mL 1.2979 mL 2.5959 mL 6.4897 mL
    30 mM 0.2163 mL 1.0816 mL 2.1632 mL 5.4081 mL
    40 mM 0.1622 mL 0.8112 mL 1.6224 mL 4.0561 mL
    50 mM 0.1298 mL 0.6490 mL 1.2979 mL 3.2449 mL
    60 mM 0.1082 mL 0.5408 mL 1.0816 mL 2.7040 mL
    80 mM 0.0811 mL 0.4056 mL 0.8112 mL 2.0280 mL
    100 mM 0.0649 mL 0.3245 mL 0.6490 mL 1.6224 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mevalonic acid lithium salt Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Mevalonic acid2618458-93-6MVAEndogenous Metabolitemevalonate pathwaymyopathyheart failureC2C12Inhibitorinhibitorinhibit

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