Mevalonic acid (Synonyms: MVA)

Cat. No.: HY-113071: Data Sheet
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Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Mevalonic acid lithium salt) that retains the same biological activity.

For research use only. We do not sell to patients.

CAS No. : 150-97-0

Size	Stock
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

Other Forms of Mevalonic acid:

Mevalonic acid lithium salt In-stock
(S)-Mevalonic acid Get quote

10 Publications Citing Use of MCE Mevalonic acid

Cell Proliferation/Viability Assay

Bio/Physico-chemical Assay

Histological Imaging/Staining

In Vivo Efficacy Study

: Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]; Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) significantly shortened activated partial thromboplastin time (APTT) and prothrombin time (PT) in C57BL/C mice.

: Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]; Mice were subjected to the inferior vena cava IVC stasis model for 5 h to evaluate venous thrombosis formation, with subsequent pathological assessment by hematoxylin and eosin (HE) staining. The results showed that Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) treatment markedly increased both thrombus weight.

: Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]; Mice were administered injections of either 500 ng/kg Mevalonic acid lithium salt (MVA). On 24 h after transient middle cerebral artery occlusion (tMCAO), typical images of coronal brain sections stained with 2,3,5-triphenyltetrazolium chloride (TTC). The results showed that MVA led to a significant increase in infarct volume.

: Mevalonic acid purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Nov;42(11):1875-1887. [Abstract]; HCT116 and LoVo cells were cultured with lovastatin (15 μM) and 2DG (5 mM) alone or in combination for 72 h in either the presence or absence of 200 mM Mevalonate, and cell proliferation was determined. *P < 0.05, **P < 0.01. ##P < 0.01 vs corresponding Mevalonic acid lithium salt (MVA) (-) group.

: Mevalonic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2021 Oct 9;11(1):179. [Abstract]; Western blotting was used to assess changes in the expression of unphosphorylated YAP in HOS and MG63 cells following a 6 h Mevalonic acid lithium salt (Meva) treatment.

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Description

In Vitro

Mevalonic acid (80, 90, 100, 110 μM; 72 h) shows prevention of simvastatin-induced loss of viability of C2C12myotube cells in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	C2C12 cells (simvastatin-induced)
Concentration:	80, 90, 100, 110 µM
Incubation Time:	72 h
Result:	Showed no decline in cell viability.

Molecular Weight

148.16

Formula

C₆H₁₂O₄

CAS No.

150-97-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC(C)(O)CCO

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (268 KB) SDS (393 KB)

COA (244 KB)

Handling Instructions (2659 KB)

References

[1]. Moschetti A, et al. Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes. Nanomedicine. 2021 Oct;37:102439. [Content Brief]

[2]. Soma MR, et al. Cholesterol and mevalonic acid modulation in cell metabolism and multiplication. Toxicol Lett. 1992 Dec;64-65 Spec No:1-15. [Content Brief]

Mevalonic acid Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mevalonic acid150-97-0MVAEndogenous Metabolitemevalonate pathwaymyopathyheart failureC2C12Inhibitorinhibitorinhibit

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