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Mevalonic acid

(Synonyms: MVA)
12 Cited Publications
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Based on 12 publication(s) in Google Scholar

Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure.

For research use only. We do not sell to patients.

  • CAS No.: 150-97-0
  • Formula: C6H12O4
  • Molecular Weight:148.16
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Mevalonic acid Chemical Structure
    Mevalonic acid Chemical Structure
  • Experimental Validation Results for Mevalonic acid
  • Experimental Validation Results for Mevalonic acid
  • Experimental Validation Results for Mevalonic acid
  • Experimental Validation Results for Mevalonic acid
  • Experimental Validation Results for Mevalonic acid
CAS No.: 150-97-0
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Cell Proliferation/Viability AssayWBBio/Physico-chemical AssayHistological Imaging/StainingIn Vivo Efficacy Study
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  • Mevalonic acid Chemical Structure
    Mevalonic acid Chemical Structure
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    Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]

    Customer Validation
     Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) significantly shortened activated partial thromboplastin time (APTT) and prothrombin time (PT) in C57BL/C mice.

  • 1/16

    Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]

    Customer Validation
     Mice were subjected to the inferior vena cava IVC stasis model for 5 h to evaluate venous thrombosis formation, with subsequent pathological assessment by hematoxylin and eosin (HE) staining. The results showed that Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) treatment markedly increased both thrombus weight.

  • 1/16

    Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]

    Customer Validation
     Mice were administered injections of either 500 ng/kg Mevalonic acid lithium salt (MVA). On 24 h after transient middle cerebral artery occlusion (tMCAO), typical images of coronal brain sections stained with 2,3,5-triphenyltetrazolium chloride (TTC). The results showed that MVA led to a significant increase in infarct volume.

  • 1/16

    Mevalonic acid purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Nov;42(11):1875-1887. [Abstract]

    Customer Validation
     HCT116 and LoVo cells were cultured with lovastatin (15 μM) and 2DG (5 mM) alone or in combination for 72 h in either the presence or absence of 200 mM Mevalonate, and cell proliferation was determined. *P < 0.05, **P < 0.01. ##P < 0.01 vs corresponding Mevalonic acid lithium salt (MVA) (-) group.

  • 1/16

    Mevalonic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2021 Oct 9;11(1):179. [Abstract]

    Customer Validation
     Western blotting was used to assess changes in the expression of unphosphorylated YAP in HOS and MG63 cells following a 6 h Mevalonic acid lithium salt (Meva) treatment.

  • Mevalonic acid