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Cat. No.: HY-130326

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RAPTA-C

(Synonyms: Ru(η6-p-cymene)Cl2(pta))

Customer Review

Based on 1 Customer Validation

RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. RAPTA-C exhibits cell growth inhibition by triggering G(2)/M phase arrest in cancer cells. RAPTA-C also enhances the levels of p53 and triggers the mitochondrial Apoptotic pathway, resulting in cytochrome C release and caspase-9 activation. RAPTA-C reduces the growth of tumors with the inhibition of angiogenesis in a ovarian carcinoma model.

For research use only. We do not sell to patients.

Purity: 99.30%
CAS No.: 372948-28-2
Formula: C₁₆H₂₃Cl₂N₃PRu
Molecular Weight:460.32

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

RAPTA-C Chemical Structure

CAS No.: 372948-28-2

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Caspase Isoforms :

Chemical Information

CAS No. 372948-28-2
Appearance Solid
Molecular Weight 460.32
Formula C₁₆H₂₃Cl₂N₃PRu
Color Yellow to orange
SMILES

CC12=C3[Ru+2]145(C6=C52)(P78C[N@@](C9)C[N@@](C[N@@]9C8)C7)([Cl-])([Cl-])C6(C(C)C)=C43
Synonyms

Ru(η6-p-cymene)Cl2(pta)
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (54.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1724 mL

10.8620 mL

21.7240 mL

5 mM

0.4345 mL

2.1724 mL

4.3448 mL

10 mM

0.2172 mL

1.0862 mL

2.1724 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rausch M, et al. Recent considerations in the application of RAPTA‐C for cancer treatment and perspectives for its combination with immunotherapies[J]. Advanced Therapeutics, 2019, 2(9): 1900042.

[2]. Weiss A, et al. In vivo anti-tumor activity of the organometallic ruthenium (II)-arene complex [Ru (η 6-p-cymene) Cl 2 (pta)](RAPTA-C) in human ovarian and colorectal carcinomas[J]. Chemical Science, 2014, 5(12): 4742-4748.

[3]. Chatterjee S, et al. The ruthenium(II)-arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53-JNK pathways. J Biol Inorg Chem. 2008 Sep;13(7):1149-55. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1724 mL	10.8620 mL	21.7240 mL	54.3100 mL
	5 mM	0.4345 mL	2.1724 mL	4.3448 mL	10.8620 mL
	10 mM	0.2172 mL	1.0862 mL	2.1724 mL	5.4310 mL
	15 mM	0.1448 mL	0.7241 mL	1.4483 mL	3.6207 mL
	20 mM	0.1086 mL	0.5431 mL	1.0862 mL	2.7155 mL
	25 mM	0.0869 mL	0.4345 mL	0.8690 mL	2.1724 mL
	30 mM	0.0724 mL	0.3621 mL	0.7241 mL	1.8103 mL
	40 mM	0.0543 mL	0.2716 mL	0.5431 mL	1.3578 mL
	50 mM	0.0434 mL	0.2172 mL	0.4345 mL	1.0862 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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RAPTA-C

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Anti-Cardiovascular Disease Compound Library

Cell Death Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

All Caspase Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

RAPTA-C

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Anti-Cardiovascular Disease Compound Library

Cell Death Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

All Caspase Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

RAPTA-C Related Classifications

HY-130326 Related Classifications