Edonentan (Synonyms: BMS 207940)

Cat. No.: HY-15402 Purity: 99.13%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Edonentan (BMS 207940) is an antagonist for endothelin receptor (ET_A receptor), with a K_i of 10 pM. Edonentan is metabolic stable, exhibits good pharmakokinetic characters in rats. Edonentan regulates the endothelin system, blocks the big Endothelin-induced pressor response in rats model.

For research use only. We do not sell to patients.

Edonentan Chemical Structure

CAS No. : 210891-04-6

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Edonentan:

Edonentan hydrate Get quote

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ET_A ET_B

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

ET_A

10 pM (Ki)

ET_B

810 nM (Ki)

Molecular Weight

536.64

Formula

C₂₈H₃₂N₄O₅S

CAS No.

210891-04-6

Appearance

Solid

Color

White to light yellow

SMILES

CC(C)(C)CC(N(CC1=CC(C2=NC=CO2)=CC=C1C3=CC=CC=C3S(=O)(NC4=NOC(C)=C4C)=O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 55 mg/mL (102.49 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8634 mL	9.3172 mL	18.6345 mL
5 mM	0.3727 mL	1.8634 mL	3.7269 mL
10 mM	0.1863 mL	0.9317 mL	1.8634 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.13%

Select Batch:

Data Sheet (275 KB) SDS (254 KB)

COA (255 KB) HNMR (189 KB) LCMS (166 KB)

Handling Instructions (2659 KB)

References

[1]. Murugesan N, et al., Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003 Jan 2;46(1):125-37. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8634 mL	9.3172 mL	18.6345 mL	46.5862 mL
	5 mM	0.3727 mL	1.8634 mL	3.7269 mL	9.3172 mL
	10 mM	0.1863 mL	0.9317 mL	1.8634 mL	4.6586 mL
	15 mM	0.1242 mL	0.6211 mL	1.2423 mL	3.1057 mL
	20 mM	0.0932 mL	0.4659 mL	0.9317 mL	2.3293 mL
	25 mM	0.0745 mL	0.3727 mL	0.7454 mL	1.8634 mL
	30 mM	0.0621 mL	0.3106 mL	0.6211 mL	1.5529 mL
	40 mM	0.0466 mL	0.2329 mL	0.4659 mL	1.1647 mL
	50 mM	0.0373 mL	0.1863 mL	0.3727 mL	0.9317 mL
	60 mM	0.0311 mL	0.1553 mL	0.3106 mL	0.7764 mL
	80 mM	0.0233 mL	0.1165 mL	0.2329 mL	0.5823 mL
	100 mM	0.0186 mL	0.0932 mL	0.1863 mL	0.4659 mL

Edonentan Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Edonentan210891-04-6BMS 207940BMS207940BMS-207940Endothelin Receptorheart failurepulmonary hypertensionatherosclerosisrestenosissystemic hypertensionSprague-Dawley ratsCHO cellInhibitorinhibitorinhibit

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Edonentan (Synonyms: BMS 207940)

Customer Review

Other Forms of Edonentan:

Edonentan Related Antibodies

Featured Recommendations

•Related Screening Libraries:

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View All Endothelin Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Edonentan Related Classifications

Keywords:

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Customer Review

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SAFETY DATA SHEET (SDS)

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