2. GPCR/G Protein Others TGF-beta/Smad
  3. Endothelin Receptor Reference Standards TGF-β Receptor
  4. Sitaxsentan sodium (Standard)

Sitaxsentan sodium (Standard)  (Synonyms: IPI 1040 sodium (Standard); TBC11251 sodium (Standard))

Cat. No.: HY-11103R Purity: 98%
Handling Instructions Technical Support

Sitaxsentan (sodium) (Standard) is the analytical standard of Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) (HY-11103). This product is intended for research and analytical applications. Sitaxsentan sodium is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan sodium can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension.

For research use only. We do not sell to patients.

Sitaxsentan sodium (Standard)

Sitaxsentan sodium (Standard) Chemical Structure

CAS No. : 210421-74-2

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5 mg Get quote 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 4 - 6 weeks
10 mg Get quote 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 4 - 6 weeks
25 mg Get quote 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 4 - 6 weeks
50 mg Get quote 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 4 - 6 weeks
100 mg Get quote 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 4 - 6 weeks
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Information

Sitaxsentan (sodium) (Standard) is the analytical standard of Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) (HY-11103). This product is intended for research and analytical applications. Sitaxsentan sodium is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan sodium can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

476.89

Formula

C18H14ClN2NaO6S2
CAS No.
SMILES

O=S(C1=C(SC=C1)C(CC2=C(C=C3OCOC3=C2)C)=O)(N([Na])C4=C(C(C)=NO4)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Sitaxsentan sodium (Standard) Related Classifications

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Keywords:

Sitaxsentan sodium (Standard)210421-74-2IPI 1040 sodium (Standard) TBC11251 sodium (Standard)Endothelin ReceptorReference StandardsTGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

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