2. GPCR/G Protein
  3. Endothelin Receptor
  4. Clazosentan

Clazosentan  (Synonyms: Ro 61-1790; VML 588; AXV-034343)

Cat. No.: HY-17352 Purity: 98.01%
COA Handling Instructions

Molarity Calculator

Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction.

For research use only. We do not sell to patients.

Clazosentan Chemical Structure

Clazosentan Chemical Structure

CAS No. : 180384-56-9

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 250 In-stock
10 mg USD 420 In-stock
25 mg USD 920 In-stock
50 mg USD 1500 In-stock
100 mg USD 1950 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Clazosentan Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5].

In Vitro

Clazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries[3].
Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clazosentan Related Antibodies
In Vivo

Clazosentan (10 μM, 0.05 mL/kg, intracisternal injection) inhibits the contractile responses to ET-1 in rats[2].
Clazosentan (10 mg/kg, s.c.) inhibits IL-33-induced hypernociception in mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[2]
Dosage: 10 μM, 0.05 mL/kg
Administration: Intracisternal injection
Result: Inhibited the contractile responses to ET-1, without preventing SAH-induced upregulation of ET receptors in cerebral arteries.
Clinical Trial
Molecular Weight

577.57

Formula

C25H23N9O6S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=NC=C(C)C=C1)(NC2=NC(C3=CC(C4=NNN=N4)=NC=C3)=NC(OCCO)=C2OC5=CC=CC=C5OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (144.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7314 mL 8.6570 mL 17.3139 mL
5 mM 0.3463 mL 1.7314 mL 3.4628 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7314 mL 8.6570 mL 17.3139 mL 43.2848 mL
5 mM 0.3463 mL 1.7314 mL 3.4628 mL 8.6570 mL
10 mM 0.1731 mL 0.8657 mL 1.7314 mL 4.3285 mL
15 mM 0.1154 mL 0.5771 mL 1.1543 mL 2.8857 mL
20 mM 0.0866 mL 0.4328 mL 0.8657 mL 2.1642 mL
25 mM 0.0693 mL 0.3463 mL 0.6926 mL 1.7314 mL
30 mM 0.0577 mL 0.2886 mL 0.5771 mL 1.4428 mL
40 mM 0.0433 mL 0.2164 mL 0.4328 mL 1.0821 mL
50 mM 0.0346 mL 0.1731 mL 0.3463 mL 0.8657 mL
60 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.7214 mL
80 mM 0.0216 mL 0.1082 mL 0.2164 mL 0.5411 mL
100 mM 0.0173 mL 0.0866 mL 0.1731 mL 0.4328 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Clazosentan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clazosentan180384-56-9Ro 61-1790 VML 588 AXV-034343VML588VML 588VML-588AXV034343AXV 034343AXV-034343Endothelin ReceptorVasoconstrictionET-1vasospasmOATPInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Clazosentan
Cat. No.:
HY-17352
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.