Asterric Acid
Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET)-1 to the ETA receptor in A10 cells at 0.1 μM.1 Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 μM, which suggests its usefulness as an antiangiogenic agent.
For research use only. We do not sell to patients.
- CAS No.: 577-64-0
- Formula: C17H16O8
- Molecular Weight:348.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A10 | IC50 |
1 x 10-5 M
Compound: 3
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Displacement of endothelin-1 from ETA receptor in rat A10 cells
Displacement of endothelin-1 from ETA receptor in rat A10 cells
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[PMID: 11809055] |
Chemical Information
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CAS No. 577-64-0
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Molecular Weight 348.30
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Formula C17H16O8
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SMILES
CC1=CC(O)=C(C(OC2=C(C=C(C=C2C(OC)=O)O)OC)=C1)C(O)=O
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Synonyms
Dimethylosoic acid; RES-1214-1; TAN 1415A
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Endothelial Tube Formation Assay
Endothelial tube formation assay evaluates the ability of endothelial cells to attach, migrate, align, and organize into capillary-like networks when cultured on gelled basement membrane extract or Matrigel; the readout is the morphology and quantity of tube-like networks, which reflects an in vitro endothelial morphogenesis step related to angiogenesis. Basement membrane extract/Matrigel provides laminin-rich extracellular matrix cues that support endothelial differentiation into capillary-like structures, but it can contain biologically active growth factors, so growth-factor-reduced matrix is preferred when testing defined angiogenic stimulators or inhibitors.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Asterric Acid Related Classifications
HY-119843 Related Classifications
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