HIV-1 inhibitor-47
Based on 1 Customer Validation
HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 137448-39-6
- Formula: C12H14N6
- Molecular Weight:242.28
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
HIV (Vif-dependent degradation of human APOBEC3G)[1]
APOBEC3G (A3G), a host cytidine deaminase that can block HIV-1 replication and shows antiviral activity. However HIV-1 develops the ability to hijack the cellular ubiquitin/proteasome degradation pathway[1].
HIV-1 inhibitor-47 targets APOBEC3G-apolipoprotein B mRNA editing enzyme catalytic subunit 3G (human), and works on the HIV-1 Vif-APOBEC3G interaction[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 137448-39-6
-
Appearance Solid
-
Molecular Weight 242.28
-
Formula C12H14N6
-
Color White to off-white
-
SMILES
C1(N2CCN(CC2)C3=NC=CC=N3)=NC=CN=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 16.67 mg/mL (68.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1275 mL | 20.6373 mL | 41.2746 mL | 103.1864 mL |
| 5 mM | 0.8255 mL | 4.1275 mL | 8.2549 mL | 20.6373 mL | |
| 10 mM | 0.4127 mL | 2.0637 mL | 4.1275 mL | 10.3186 mL | |
| 15 mM | 0.2752 mL | 1.3758 mL | 2.7516 mL | 6.8791 mL | |
| 20 mM | 0.2064 mL | 1.0319 mL | 2.0637 mL | 5.1593 mL | |
| 25 mM | 0.1651 mL | 0.8255 mL | 1.6510 mL | 4.1275 mL | |
| 30 mM | 0.1376 mL | 0.6879 mL | 1.3758 mL | 3.4395 mL | |
| 40 mM | 0.1032 mL | 0.5159 mL | 1.0319 mL | 2.5797 mL | |
| 50 mM | 0.0825 mL | 0.4127 mL | 0.8255 mL | 2.0637 mL | |
| 60 mM | 0.0688 mL | 0.3440 mL | 0.6879 mL | 1.7198 mL |
HIV-1 inhibitor-47 Related Classifications
HY-148042 Related Classifications
Powered by Bioz