137448-39-6
137448-39-6
Chemical Structure
HIV-1 inhibitor-47
- CAS No.: 137448-39-6
- Formula:C12H14N6
- Molecular Weight:242.28
IUPAC Name: 2-(4-(pyrazin-2-yl)piperazin-1-yl)pyrimidine
InChIKey: ZHRRMTBJVSOJRB-UHFFFAOYSA-N
SMILES: C1(N2CCN(CC2)C3=NC=CC=N3)=NC=CN=C1
Biological Activity: HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HIV-1 inhibitor-47 | 98.0% | HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect. | ||||||||||||||||||||
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References
- [1]. Iwatani Y, et al. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19539-44. [Content Brief]
- [2]. Becker Irwin. Preparation of derivatives of 1-(2-pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents. Journal of Heterocyclic Chemistry. 2008;45(4):1005-1022.
- [3]. Pubchem: 2-(4-(Pyrazin-2-yl)piperazin-1-yl)pyrimidine-BioAssay Results.
Keywords
