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Pathways Recommended:	Anti-infection

Results for "

escherichia coli infection

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (5) Aminopeptidase (1) Amyloid-β (1) Androgen Receptor (2) Antibiotic (43) Apoptosis (4) Autophagy (3) Bacterial (126) Bcl-2 Family (1) Beta-lactamase (6) Biochemical Assay Reagents (5) Caspase (4) ClpP (2) COX (1) Dihydrofolate reductase (DHFR) (2) DNA Alkylator/Crosslinker (1) DNA-PK (3) DNA/RNA Synthesis (17) Drug Derivative (2) Drug Intermediate (3) Drug Isomer (1) Drug Metabolite (5) Endogenous Metabolite (5) Environmental Pollutants (1) Fluorescent Dye (1) Fungal (11) Isotope-Labeled Compounds (13) Liposome (1) Lipoxygenase (1) MDM-2/p53 (3) MetAP (1) mTOR (1) NF-κB (1) NTPDase (1) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (1) Parasite (10) PARP (4) Penicillin-binding protein (PBP) (12) Phosphatase (1) PI3K (2) PPAR (3) Reactive Oxygen Species (ROS) (6) Reference Standards (11) SOD (3) Tie (1) Toll-like Receptor (TLR) (1) Topoisomerase (14) β-glucuronidase (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (1) Infection (135) Inflammation/Immunology (22) Metabolic Disease (4) Neurological Disease (3)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (1) Cationic Lipids (1)

143

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2764

Apyrase 3 Publications Verification	NTPDase	Inflammation/Immunology
Apyrase is an Nucleoside triphosphate diphosphohydrolase (NTPDase). Apyrase can hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP). Apyrase can inhibit Stx2 toxin release of enterohemorrhagic Escherichia coli (EHEC) infection and protect the intestinal barrier function. Apyrase can be used for the research of infection and inflammation, such as hemorrhagic colitis .

HY-164036

Lolamicin	Antibiotic Bacterial	Infection
Lolamicin is an orally effective inhibitor that specifically targets the Gram-negative bacteria lipoprotein transport system LolCDE complex. It selectively inhibits the transmembrane transport of outer membrane lipoproteins by competitively binding to lipoprotein binding sites. Lolamicin destroys the integrity of the bacterial outer membrane, leading to cell death, and has both bactericidal and antibacterial activity. It has significant effects on multidrug-resistant Enterobacteriaceae pathogens (such as Escherichia coli and Klebsiella pneumoniae). Lolamicin can be used to inhibit the study of acute pneumonia, sepsis and other infections caused by Gram-negative bacteria .

HY-B0147

Pefloxacin 3 Publications Verification Pefloxacinium	Antibiotic Bacterial Parasite DNA/RNA Synthesis Topoisomerase	Infection Inflammation/Immunology
Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-A0111

Cefetamet 1 Publications Verification Ro 15-8074; Deacetoxycefotaxime	Antibiotic Bacterial Penicillin-binding protein (PBP) Drug Metabolite	Infection
Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC₅₀ for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis .

HY-W011117

Danofloxacin	Bacterial DNA/RNA Synthesis Antibiotic	Infection
Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens .

HY-B0333

Sulfamethizole 2 Publications Verification	Antibiotic Bacterial	Infection
Sulfamethizole is a sulfathiazole antibiotic. Sulfamethizole inhibits the synthesis of folic acid and thymine, and selectively suppresses Photobacterium phosphoreum bioluminescence. Sulfamethizole exerts antibacterial activity against Escherichia coli-mediated urinary tract infections but no activity against sulII gene-positive Escherichia coli. Sulfamethizole is applicable for the research of urinary tract infections and Photobacterium phosphoreum bioluminescence mechanisms .

HY-N3651

Curzerenone 1 Publications Verification	Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt mTOR	Infection Cancer
Curzerenone is an orally active sesquiterpene compound and Antibacterial agent. Curzerenone can be isolated from Curcuma zedoaria and Curcuma aeruginosa plants. Curzerenone increases ROS levels, activates Apoptotic signaling pathways, and attenuates the PI3K/AKT/mTOR signaling pathway. Curzerenone exhibits anticancer activity against liver cancer and cervical cancer. Curzerenone has antioxidant effects. Curzerenone shows weak antibacterial activity against Escherichia coli. Curzerenone can be used in research related to hepatocellular carcinoma, cervical cancer, and Escherichia coli infection .

HY-30236

5-Bromoindole	Bacterial	Infection
5-Bromoindole is an antibacterial agent with a MIC of 200 μg/mL. 5-Bromoindole inhibits biofilm and curli formation, reduces swarming motility and swimming motility. 5-Bromoindole can be used for the research of enterohemorrhagic escherichia coli o157:h7 infection .

HY-N8574

1-Heptacosanol Heptacosan-1-ol	Biochemical Assay Reagents	Infection
1-Heptacosanol (Heptacosan-1-ol) is a long-chain fatty alcohol with antifungal, antibacterial (against Escherichia coli and Staphylococcus aureus), nematicidal, anticancer and antioxidant activities. 1-Heptacosanol can be isolated from leaf extracts of Ficus septica and Lecaniodiscus cupanioides. 1-Heptacosanol not only effectively resists pathogenic fungal infections, but also shows potential against pepper anthracnose in phytopathology. 1-Heptacosanol can be used in the research of fungal infections, cancer and oxidative stress-related diseases .

HY-B1415

Clofibric acid Chlorofibrinic acid	PPAR Bacterial SOD	Infection Metabolic Disease Cancer
Clofibric acid (Chlorofibrinic acid) is an orally active PPARα agonist. Clofibric acid inhibits the fimbriation of **Escherichia coli. Clofibric acid increases SOD** activity. Clofibric acid lowers blood lipids and prevents experimental pyelonephritis. Clofibric acid has anticancer activity against ovarian cancer. Clofibric acid is also a herbicide. Clofibric acid is used in ovarian cancer, liver cancer, obesity, and urinary tract infection research .

HY-N7101

Cefpodoxime Proxetil U-76,252; CS-807	Bacterial Antibiotic Penicillin-binding protein (PBP)	Infection
Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .

HY-B0960

Sulfabenzamide 1 Publications Verification N-Sulfanilylbenzamide	Bacterial Autophagy MDM-2/p53 Caspase PARP DNA-PK Akt	Infection Cancer
Sulfabenzamide (N-Sulfanilylbenzamide) is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections .

HY-P3302

Sialylglycopeptide	Bacterial	Infection
Sialylglycopeptide is an orally active glycopeptide found in egg yolk. Sialylglycopeptide inhibits the binding of Salmonella enteritidis and Escherichia coli to intestinal cells, and protects mice from Salmonella infection. Sialylglycopeptide can be used in the research of Salmonella infection .

HY-B0147A

Pefloxacin mesylate 3 Publications Verification Pefloxacinium mesylate	Topoisomerase DNA/RNA Synthesis Antibiotic Bacterial Parasite	Infection Inflammation/Immunology
Pefloxacin (Pefloxacinium) mesylate is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin mesylate inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin mesylate exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin mesylate has anti-Plasmodium yoelii infection activity. Pefloxacin mesylate increase UVA-induced edema and immunesuppression. Pefloxacin mesylate can be used for infection studies .

HY-148442

ecMetAP-IN-1	MetAP Bacterial	Infection
ecMetAP-IN-1 is an inhibitor of E. coli methionine aminopeptidase (ecMetAP) with an IC₅₀ of 2.086 μM. ecMetAP-IN-1 is applicable to research related to bacterial infections caused by E. coli .

HY-W009886

3,4,5-Trimethoxybenzaldehyde	Bacterial Drug Intermediate	Infection
3,4,5-Trimethoxybenzaldehyde is a derivative of benzaldehyde. 3,4,5-Trimethoxybenzaldehyde has antimicrobial activity. 3,4,5-Trimethoxybenzaldehyde is also an important intermediate for the synthesis of various drugs, such as Trimethoprim (HY-B0510) .

HY-W014665

N-Phthaloylglycine Phthaloyl glycine	Bacterial Fungal	Infection
N-Phthaloylglycine (Phthaloyl glycine) is a Type II fragmentary hapten (FX-type) with antimicrobial activity. N-Phthaloylglycine acts against Candida albicans, Escherichia coli, and Staphylococcus epidermidis. N-Phthaloylglycine can be used for the research of fungal and bacterial infection .

HY-Y1718S

Tridecanoic acid-d2 N-Tridecanoic acid-d₂	Isotope-Labeled Compounds Endogenous Metabolite Bacterial	Infection
Tridecanoic acid-d₂ is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .

HY-Y1718S1

Tridecanoic acid-d25 N-Tridecanoic acid-d₂₅	Isotope-Labeled Compounds Endogenous Metabolite Bacterial	Cancer
Tridecanoic acid-d₂₅ is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .

HY-123515

Clorobiocin		Infection
Clorobiocin is an antibacterial agent with an IC₅₀ of 0.21 μM against the B subunit of E. coli DNA gyrase. Clorobiocin targets the mLaC protein of Gram-negative bacteria. Clorobiocin potently inhibits bacterial DNA replication. Clorobiocin can be used in studies on Gram-negative bacterial infections, such as Acinetobacter baumannii and E. coli infections .

HY-148790

Pralurbactam FL058	Bacterial Beta-lactamase	Infection
Pralurbactam (FL058) is a β-lactamase (Beta-lactamase) inhibitor. Pralurbactam enhances the antibacterial activity of Imipenem against Mycobacterium abscessus. Pralurbactam reduces the pulmonary bacterial load in neutropenic mice infected with Mycobacterium abscessus. Pralurbactam can be used in research related to infections caused by Mycobacterium abscessus complex, Escherichia coli, and Klebsiella pneumoniae .

HY-175597

ClpP modulator-1	ClpP	Infection
ClpP modulator-1 (Compound BC8a), a peptidomimetic, is an allosteric ClpP modulator. ClpP modulator-1 is a ClpP activator at low concentration with EC₅₀s of 0.35 and 0.58  μM for for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP), resepectively. ClpP modulator-1 also inhibits peptidase activity at high concentration by competitively inhibiting substrate protein (LY-AMC) binding to ClpP C sites. ClpP modulator-1 has antibacterial activity. ClpP modulator-1 can be used for bacterial infections research .

HY-W011549

2'-Amino-2'-deoxyguanosine	Bacterial	Infection
2'-Amino-2'-deoxyguanosine is a nucleoside antibiotic. 2'-Amino-2'-deoxyguanosine exhibits lethal activity against certain strains of Escherichia coli, with its antibacterial effect reversible by guanosine and other purine nucleosides. 2'-Amino-2'-deoxyguanosine can be used for the study of bacterial infection .

HY-N11554

(-)-Codonopsine	Bacterial	Infection
(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections .

HY-P10364

Ubiquicidin(29-41) UBI(29-41)	Bacterial Antibiotic	Infection Inflammation/Immunology
Ubiquicidin (29-41) (UBI (29-41)) is an Antimicrobial peptide and infection-localizing agent. Ubiquicidin (29-41) acts as an infection-specific imaging agent and infection-targeting agent. Ubiquicidin (29-41) serves as an antibiotic efficacy monitoring agent, and its aggregation level in infections induced by Staphylococcus aureus is higher than that in infections induced by Escherichia coli .

HY-B0967

Phthalylsulfacetamide	Antibiotic Bacterial	Infection
Phthalylsulfacetamide is an orally active sulfonamide antibiotic and New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 15.4 μM. Phthalylsulfacetamide stably binds to the active hydrolysis center of NDM-1, interacts with Zn²⁺, and interacts with key amino acid residues Val73 and His122 to inhibit enzyme activity. Phthalylsulfacetamide can be used for the research of Escherichia coli infection .

HY-177716

Ciprofloxacin prodrug-1	Beta-lactamase Bacterial	Infection
Ciprofloxacin prodrug-1 (Compound 35) is an activated prodrug of β-lactase. Ciprofloxacin prodrug-1 exhibits good antibacterial activity against bacteria containing β-lactase (MIC = 63 nM). After being hydrolyzed by β-lactase, Ciprofloxacin prodrug-1 can release Ciprofloxacin (HY-B0356), thereby inhibiting the activity of DNA gyrase. Ciprofloxacin prodrug-1 can be used to study infections caused by enzyme-producing drug-resistant bacteria (such as uropathogenic Escherichia coli) .

HY-P10980

Citrocin	DNA/RNA Synthesis Bacterial	Infection
Citrocin is a potent bacterial RNA polymerase (RNAP) inhibitor. Citrocin shows significant inhibitory activity against Escherichia coli RNAP with an MIC range of 16-125 μM. Citrocin specifically binds to and inhibits RNA polymerase to block bacterial transcription and enters cells mainly through inner membrane protein SbmA. Citrocin is promising for research of Gram-negative bacterial infections, such as enterohemorrhagic E. coli .

HY-175596

ACP1-01	ClpP Bacterial	Infection
ACP1-01 is a bacterial ClpP activator with EC₅₀s of 3.4 and 2.6  μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP). ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research .

HY-B0147B

Pefloxacin mesylate dihydrate 3 Publications Verification Pefloxacinium mesylate dihydrate	Topoisomerase DNA/RNA Synthesis Antibiotic Bacterial Parasite	Infection Inflammation/Immunology
Pefloxacin (Pefloxacinium) mesylate dihydrate is a broad spectrum antibiotic. Pefloxacin mesylate dihydrate blocks DNA replication by inhibiting DNA gyrase. Pefloxacin mesylate dihydrate inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin mesylate dihydrate exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin mesylate dihydrate has anti-Plasmodium yoelii infection activity. Pefloxacin mesylate dihydrate increase UVA-induced edema and immunesuppression. Pefloxacin mesylate dihydrate can be used for infection studies .

HY-U00380

Tigemonam	Antibiotic Beta-lactamase Bacterial	Infection
Tigemonam is an orally active monobactam antibiotic with a K_i of 0.86 μM against Enterobacter cloacae P99 β-lactamase and 50.8 μM against Escherichia coli TEM-1 β-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam resists hydrolysis by multiple β-lactamase enzymes, reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection, and thigh muscle infection .

HY-B0960S

Sulfabenzamide-d4 N-Sulfanilylbenzamide-d₄	Bacterial Autophagy Isotope-Labeled Compounds MDM-2/p53 Caspase PARP DNA-PK Akt	Infection Cancer
Sulfabenzamide (N-Sulfanilylbenzamide)-d₄ is the deuterium labeled Sulfabenzamide (HY-B0960). Sulfabenzamide is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections .

HY-101444

MC-207110	Bacterial	Infection
MC-207110 is a broad-spectrum efflux pump inhibitor. MC-207110 is active against all three known Mex efflux pumps from P. aeruginosa and their close Escherichia coli efflux pump homolog (AcrAB-TolC). MC-207110 can decrease the intrinsic resistance of P. aeruginosa to fluoroquinolones. MC-207110 can be used for the research of infection .

HY-117951

ANT431	Beta-lactamase	Infection
ANT431 is a metallo-β-lactamase inhibitor that also restores the effectiveness of Meropenem (HY-13678) in a mouse thigh Escherichia coli infection model .

HY-107064

Cefroxadine CGP 9000; Oraspor	Bacterial Antibiotic	Infection
Cefroxadine (CGP 9000) is an orally active cephalosporin antibiotic. Cefroxadine is more effective than cephalexin against Escherichia coli and Klebsiella pneumoniae with MIC values of 3.13 and 1.56 μg/mL respectively with a concentration of 10 ⁶ μg/mL. Cefroxadine can be used for the research of infection .

HY-B0960R

Sulfabenzamide (Standard) N-Sulfanilylbenzamide (Standard)	Reference Standards Bacterial Autophagy MDM-2/p53 Caspase PARP DNA-PK Akt	Infection Cancer
Sulfabenzamide (N-Sulfanilylbenzamide) (Standard) is the analytical standard of Sulfabenzamide (HY-B0960). This product is intended for research and analytical applications. Sulfabenzamide is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections .

HY-170835

NDM-1 inhibitor-7	Beta-lactamase Bacterial	Infection Inflammation/Immunology
NDM-1 inhibitor-7 (Compound A8) is a NDM-1 inhibitor, with IC₅₀ of 10.284 μM. NDM-1 inhibitor-7 restores the ability of MEM to penetrate the cell wall of gram-negative bacteria. NDM-1 inhibitor-7 effectively restores the antibacterial activity of MEM against NDM-1-positive Escherichia coli. NDM-1 inhibitor-7 demonstrates strong efficacy in both the Galleria mellonella infection model and murine peritonitis infection model .

HY-161404

Antibacterial agent 202	Bacterial	Infection
Antibacterial agent 202 (compound 45c) is a low cytotoxicity bacterial inhibitor with good activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumonia, especially Pseudomonas aeruginosa, (MIC (minimum inhibitory concentration)=7.8-31.25 μM). Antibacterial agent 202 can exert antibacterial activity by destroying the integrity of cell membranes and can be used in the research of bacterial infections .

HY-B0333S

Sulfamethizole-d4	Isotope-Labeled Compounds Androgen Receptor	Infection
Sulfamethizole-d₄ is the deuterium labeled Sulfamethizole (HY-B0333). Sulfamethizole is a sulfathiazole antibiotic. Sulfamethizole inhibits the synthesis of folic acid and thymine, and selectively suppresses Photobacterium phosphoreum bioluminescence. Sulfamethizole exerts antibacterial activity against Escherichia coli-mediated urinary tract infections but no activity against sulII gene-positive Escherichia coli. Sulfamethizole is applicable for the research of urinary tract infections and Photobacterium phosphoreum bioluminescence mechanisms .

HY-B0333S2

Sulfamethizole-d4-1	Isotope-Labeled Compounds Androgen Receptor Bacterial Antibiotic	Infection
Sulfamethizole-d₄-1 is the deuterium labeled Sulfamethizole (HY-B0333). Sulfamethizole is a sulfathiazole antibiotic. Sulfamethizole inhibits the synthesis of folic acid and thymine, and selectively suppresses Photobacterium phosphoreum bioluminescence. Sulfamethizole exerts antibacterial activity against Escherichia coli-mediated urinary tract infections but no activity against sulII gene-positive Escherichia coli. Sulfamethizole is applicable for the research of urinary tract infections and Photobacterium phosphoreum bioluminescence mechanisms .

HY-B0333R

Sulfamethizole (Standard)	Reference Standards Antibiotic Bacterial	Infection
Sulfamethizole (Standard) is the analytical standard of Sulfamethizole (HY-B0333). This product is intended for research and analytical applications. Sulfamethizole is a sulfathiazole antibiotic. Sulfamethizole inhibits the synthesis of folic acid and thymine, and selectively suppresses Photobacterium phosphoreum bioluminescence. Sulfamethizole exerts antibacterial activity against Escherichia coli-mediated urinary tract infections but no activity against sulII gene-positive Escherichia coli. Sulfamethizole is applicable for the research of urinary tract infections and Photobacterium phosphoreum bioluminescence mechanisms .

HY-162884

β-Glucuronidase-IN-4	β-glucuronidase	Infection
EcGUS-IN-1 (Compound E-9) is a non-competitive β-glucuronidase inhibitor, with an IC₅₀ of 2.68 μM and a K_i value of 1.64 μM. EcGUS-IN-1 can improve gastrointestinal adverse events (GIAE) caused by Escherichia coli infection by inhibiting E. coli β-glucuronidase activity .

HY-170567

DNA gyrase/Topo IV-IN-1	Topoisomerase Bacterial Antibiotic	Infection
DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV, exhibiting antibacterial activity. For Escherichia coli and methicillin-resistant Staphylococcus aureus DNA gyrases, DNA gyrase/Topo IV-IN-1 has an IC₅₀ of 11 and 17 nM respectively, and for topoisomerase IV of Escherichia coli and methicillin-resistant Staphylococcus aureus, the IC₅₀ values are 83 and 21 nM respectively. DNA gyrase/Topo IV-IN-1 can be used for research in the field of anti-infection .

HY-159809

Antibacterial agent 249	Bacterial	Infection Inflammation/Immunology
Antibacterial agent 249 demonstrates broad-spectrum antimicrobial properties, effectively inhibiting the growth of Aspergillus niger, Bacillus subtilis, Pseudomonas albicans, Escherichia coli, and Staphylococcus aureus, while also exhibiting anti-inflammatory activity in vitro, making it a potential candidate for treating bacterial infections.

HY-W011117S

Danofloxacin-d3	Isotope-Labeled Compounds Bacterial DNA/RNA Synthesis Antibiotic	Infection
Danofloxacin-d₃ is deuterium labeled Danofloxacin. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

HY-W011117S1

Danofloxacin-d3-1	Isotope-Labeled Compounds Bacterial DNA/RNA Synthesis Antibiotic	Infection
Danofloxacin-d3-1 is deuterium labeled Danofloxacin. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

HY-Y1718S2

Tridecanoic acid-d9 N-Tridecanoic acid-d₉	Isotope-Labeled Compounds Endogenous Metabolite Bacterial	Infection
Tridecanoic acid-d₉ is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .

HY-W011117R

Danofloxacin (Standard)	Reference Standards Bacterial DNA/RNA Synthesis Antibiotic	Infection
Danofloxacin (Standard) is the analytical standard of Danofloxacin. This product is intended for research and analytical applications. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

HY-Y1718R

Tridecanoic acid (Standard) N-Tridecanoic acid (Standard)	Reference Standards Endogenous Metabolite Bacterial	Infection Metabolic Disease
Tridecanoic acid (Standard) is the analytical standard of Tridecanoic acid. This product is intended for research and analytical applications. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .

HY-119086

L-651392	Lipoxygenase	Inflammation/Immunology
L-651392 is an orally active and specific 5-lipoxygenase inhibitor that inhibits the production of leukotrienes. L-651392 controls the inflammatory process in Escherichia coli pyelonephritis by preventing inflammatory cells from reaching the site of infection and protecting the renal tubules from inflammation-related damage during pyelonephritis .

Cat. No.	Product Name	Type

HY-D3192

CDy11

Fluorescent Dyes

CDy11 is a fluorescent probe and amyloid-binding dye (λ_ex=590 nm; λ_em=612 nm), with a K_a of 29 μM for Pseudomonas aeruginosa Fap. CDy11 specifically recognizes amyloid fibrils in bacterial biofilms and exhibits significantly enhanced fluorescence upon binding to the target. CDy11 shows no staining effect on amyloid-deficient mutant strains, planktonic cells or protein monomers. CDy11 supports in vivo imaging of Pseudomonas aeruginosa biofilms in mouse implant and corneal infection models. CDy11 is widely used in studies of Staphylococcus aureus biofilm infections, dental caries, and Pseudomonas aeruginosa-associated implant and corneal infections .

Cat. No.	Product Name	Type

HY-D1056A3

Lipopolysaccharides, from E. coli O26:B6

LPS, from escherichia coli (O26:B6)

Biochemical Assay Reagents

Lipopolysaccharides, from E. coli (Escherichia coli) O26:B6 are lipopolysaccharide endotoxins and TLR-4 activators derived from E. coli, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from E. coli O26:B6 exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A, and can be recognized by the core-specific monoclonal antibody MAb J8-4C10. Lipopolysaccharides, from E. coli O26:B6 can promote an increase in pro-inflammatory cytokines in plasma, thereby triggering hypothalamic-pituitary-adrenal (HPA) activation and leading to adrenal oxidative damage. The pathogenic effects of Lipopolysaccharides, from E. coli O26:B6 can be used to construct various models, such as cellular inflammation models, sepsis, acute lung injury models, adrenal dysfunction models, and bladder infection models, etc .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

HY-N8574

1-Heptacosanol

Heptacosan-1-ol

Biochemical Assay Reagents

1-Heptacosanol (Heptacosan-1-ol) is a long-chain fatty alcohol with antifungal, antibacterial (against Escherichia coli and Staphylococcus aureus), nematicidal, anticancer and antioxidant activities. 1-Heptacosanol can be isolated from leaf extracts of Ficus septica and Lecaniodiscus cupanioides. 1-Heptacosanol not only effectively resists pathogenic fungal infections, but also shows potential against pepper anthracnose in phytopathology. 1-Heptacosanol can be used in the research of fungal infections, cancer and oxidative stress-related diseases .

HY-W014141

5,6-O-Isopropylidene-L-ascorbic acid L-Ascorbic acid 5,6-acetonide	Biochemical Assay Reagents
5,6-O-Isopropylidene-L-ascorbic acid (L-Ascorbic acid 5,6-acetonide) is an organic compound and a derivative of L-ascorbic acid (vitamin C). 5,6-O-Isopropylidene-L-ascorbic acid inhibits biofilm formation by pathogenic bacteria. 5,6-O-Isopropylidene-L-ascorbic acid is applicable to studies related to bacterial infections .

HY-W011549

2'-Amino-2'-deoxyguanosine	Biochemical Assay Reagents
2'-Amino-2'-deoxyguanosine is a nucleoside antibiotic. 2'-Amino-2'-deoxyguanosine exhibits lethal activity against certain strains of Escherichia coli, with its antibacterial effect reversible by guanosine and other purine nucleosides. 2'-Amino-2'-deoxyguanosine can be used for the study of bacterial infection .

Cat. No.	Product Name	Target	Research Area

HY-P3302

Sialylglycopeptide	Bacterial	Infection
Sialylglycopeptide is an orally active glycopeptide found in egg yolk. Sialylglycopeptide inhibits the binding of Salmonella enteritidis and Escherichia coli to intestinal cells, and protects mice from Salmonella infection. Sialylglycopeptide can be used in the research of Salmonella infection .

HY-P11085

WLBU2	Bacterial	Infection
WLBU2 is a engineered cationic antimicrobial peptide (eCAP) that overcomes the environmental sensitivity of natural antimicrobial peptides (AMPs). WLBU2 exhibits rapid bactericidal effect, with the MIC values of ≤ 10 μM against both Gram-negative and Gram-positive bacteria including MRSA, vancomycin-resistant enterococci, K. pneumoniae, E.aerogenes, E. cloacae, Escherichia coli, et, al. WLBU2 prevents P. aeruginosa biofilm growth and retains its activity in an environment rich in mucus, low pH and high salt concentrations without negative effects on human airway epithelial cells. WLBU2 can be used for the studies of cystic fibrosis (CF) and Pseudomonas aeruginosa infections .

HY-P10364

Ubiquicidin(29-41) UBI(29-41)	Bacterial Antibiotic	Infection Inflammation/Immunology
Ubiquicidin (29-41) (UBI (29-41)) is an Antimicrobial peptide and infection-localizing agent. Ubiquicidin (29-41) acts as an infection-specific imaging agent and infection-targeting agent. Ubiquicidin (29-41) serves as an antibiotic efficacy monitoring agent, and its aggregation level in infections induced by Staphylococcus aureus is higher than that in infections induced by Escherichia coli .

HY-P10980

Citrocin	DNA/RNA Synthesis Bacterial	Infection
Citrocin is a potent bacterial RNA polymerase (RNAP) inhibitor. Citrocin shows significant inhibitory activity against Escherichia coli RNAP with an MIC range of 16-125 μM. Citrocin specifically binds to and inhibits RNA polymerase to block bacterial transcription and enters cells mainly through inner membrane protein SbmA. Citrocin is promising for research of Gram-negative bacterial infections, such as enterohemorrhagic E. coli .

HY-P11109

RL-37	Antibiotic Bacterial	Infection
RL-37 is an alpha-helical antimicrobial peptide. RL-37 can be isolated for rhesus monkey bone marrow. RL-37 rapidly permeabilizes the membranes of Escherichia coli ML-35p and lysed liposomes. RL-37 has effective antibacterial activity against staphylococci, such as wild-type and Methicillin (HY-121544)-resistant S. aureus strains and S. epidermidis ATCC 49741. RL-37 can be used for human skin infections research .

HY-P11825

APH-IN-1	Bacterial	Infection
APH-IN-1 is an Aminoglycoside phosphotransferase (APH) inhibitor with a K_d values of 63 nM against Escherichia coli APH(3′)-Ia. APH-IN-1 binds primarily to the ATP-binding pocket of APH in an ATP-competitive manner, with binding affinity enhanced by divalent metal ions (Mg ²⁺ and Ca ²⁺). APH-IN-1 can be used for the research of aminoglycoside-resistant bacterial infections .

HY-P11657

GN-2 peptoid	Bacterial	Infection
GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections .

HY-P11136

Latarcin 2a	Bacterial	Infection
Latarcin 2a is a linear cationic antibacterial peptide that can be isolated from the venom of the spider Lachesana tarabaevi, with broad-spectrum antibacterial activity. Latarcin 2a has a MIC of 0.5 μM for both Bacillus subtilis and Escherichia coli. Latarcin 2a is often used in the research of infectious conditions .

HY-P11085A

WLBU2 acetate	Bacterial	Infection
WLBU2 acetate is a engineered cationic antimicrobial peptide (eCAP) that overcomes the environmental sensitivity of natural antimicrobial peptides (AMPs). WLBU2 acetate exhibits rapid bactericidal effect, with the MIC values of ≤ 10 μM against both Gram-negative and Gram-positive bacteria including MRSA, vancomycin-resistant enterococci, K. pneumoniae, E.aerogenes, E. cloacae, Escherichia coli, et, al. WLBU2 acetate prevents P. aeruginosa biofilm growth and retains its activity in an environment rich in mucus, low pH and high salt concentrations without negative effects on human airway epithelial cells. WLBU2 acetate can be used for the studies of cystic fibrosis (CF) and Pseudomonas aeruginosa infections .

HY-P0307B

Penetratin-Cys	Biochemical Assay Reagents	Neurological Disease
Penetratin-Cys is a cell-penetrating peptide derived from Antennapedia Peptide (HY-P0307) via C-terminal cysteine modification. Penetratin-Cys acts as a cytotoxin and reduces the viability of differentiated neuronal cells. Penetratin-Cys localizes to the perinuclear region and binds to the Golgi apparatus. Penetratin-Cys can be used in research related to neurological disorders .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0147

Pefloxacin 3 Publications Verification Pefloxacinium	Infection Classification of Application Fields Disease Research Fields	Antibiotic Bacterial Parasite DNA/RNA Synthesis Topoisomerase
Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-N3651

Curzerenone 1 Publications Verification	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Curcuma phaeocaulis Valeton Plants Disease Research Fields Source Classification Zingiberaceae	Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt mTOR
Curzerenone is an orally active sesquiterpene compound and Antibacterial agent. Curzerenone can be isolated from Curcuma zedoaria and Curcuma aeruginosa plants. Curzerenone increases ROS levels, activates Apoptotic signaling pathways, and attenuates the PI3K/AKT/mTOR signaling pathway. Curzerenone exhibits anticancer activity against liver cancer and cervical cancer. Curzerenone has antioxidant effects. Curzerenone shows weak antibacterial activity against Escherichia coli. Curzerenone can be used in research related to hepatocellular carcinoma, cervical cancer, and Escherichia coli infection .

HY-108307

Micronomicin sulfate 1 Publications Verification Gentamicin C2b sulfate; Antibiotic XK-62-2 sulfate; Sagamicin sulfate	Infection Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml) .

HY-111664A

(S)-(-)-Citronellal (-)-Citronellal	Structural Classification Classification of Application Fields Citrus limon (L.) Burm. F. Rutaceae Cymbopogon nardus Metabolic Disease Plants Endogenous metabolite Other Monoterpenes Terpenoids Gramineae Disease Research Fields Source Classification	Drug Isomer
(S)-(-)-Citronellal ((-)-Citronellal) is an oxygenated monoterpenoid found in Citrus limon (L.) Burm. F. essential oils. (S)-(-)-Citronellal is a chiral isomers of (R)-(+)-Citronellal (HY-111664) and does not possess microtubule-disrupting activity. (S)-(-)-Citronellal can be used for cancer research .

HY-Y1718

Tridecanoic acid 1 Publications Verification N-Tridecanoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Bacterial
Tridecanoic acid (N-Tridecanoic acid) is a medium-chain saturated fatty acid and inhibitor with no antibacterial activity against enterohemorrhagic E. coli (EHEC). When used in combination with Ciprofloxacin (HY-B0356) or Ampicillin (HY-B0522), Tridecanoic acid suppresses persister formation in exponentially growing E. coli and EHEC, but exerts no inhibitory effect on persister formation induced by Kanamycin (HY-16566) or in stationary-phase cells. Tridecanoic acid inhibits biofilm formation in EHEC. It can be used in the research of bacterial infections .

HY-N2198

Podocarpusflavone A	Structural Classification Flavonoids Classification of Application Fields Guttiferae Phenols Polyphenols Plants Garcinia subelliptica Biflavones Disease Research Fields Source Classification Cancer	Fungal Bacterial Topoisomerase Apoptosis
Podocarpusflavone A is a biflavonoid present in the leaves of Podocarpus henkelii, with anti-tumor, topoisomerase I inhibitory, antibacterial and antifungal activities. Podocarpusflavone A exhibits antibacterial activity against Enterococcus faecalis and Pseudomonas aeruginosa. Podocarpusflavone A shows weak activity against fungal pathogens. Podocarpusflavone A targets topoisomerase I and induces cell cycle arrest and apoptosis in MCF-7 cells. Podocarpusflavone A can be used for studies on cancer, bacterial and fungal infections .

HY-W009886

3,4,5-Trimethoxybenzaldehyde	Clerodendrum trichotomum Thunb. Infection Classification of Application Fields Ketones, Aldehydes, Acids Verbenaceae Plants Disease Research Fields Source Classification	Bacterial Drug Intermediate
3,4,5-Trimethoxybenzaldehyde is a derivative of benzaldehyde. 3,4,5-Trimethoxybenzaldehyde has antimicrobial activity. 3,4,5-Trimethoxybenzaldehyde is also an important intermediate for the synthesis of various drugs, such as Trimethoprim (HY-B0510) .

HY-N0542

Pseudoginsenoside RT5	Triterpenes Structural Classification Panax quinquefolium Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification Cancer	Bacterial
Pseudoginsenoside RT5 is an orally active ocotillol-type ginsenoside and Antibacterial agent. Pseudoginsenoside RT5 can be isolated from American ginseng, transgenic American ginseng crown gall tumors and Panax japonicus. Pseudoginsenoside RT5 exerts cardioprotective effects against myocardial injury, and also possesses antibacterial and antitumor activities. Pseudoginsenoside RT5 can be used in research related to Alzheimer's disease, myocardial injury, tumors and bacterial infections .

HY-N11554

(-)-Codonopsine	Structural Classification Alkaloids Pyrrole Alkaloids Campanulaceae Codonopsis pilosula (Franch.) Nannf. Plants Source Classification	Bacterial
(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections .

HY-N14664

Actithiazic acid	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Actithiazic acid is a thiazolidinone antibiotic that targets biotin synthase. Actithiazic acid interferes with essential bacterial metabolism by inhibiting the final step of biotin synthesis (conversion of desthiobiotin to biotin, IC₅₀ = 0.45 μM). Actithiazic acid can be used in studies related to mycobacterial infections .

HY-Y1718R

Tridecanoic acid (Standard) N-Tridecanoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Bacterial
Tridecanoic acid (Standard) is the analytical standard of Tridecanoic acid. This product is intended for research and analytical applications. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .

HY-N19782

Striatisporolide A	Athyriaceae Structural Classification Ketones, Aldehydes, Acids Athyrium multidentatum (Döll) Ching Plants Source Classification	Bacterial Apoptosis Reactive Oxygen Species (ROS)
Striatisporolide A is an antibacterial agent. Striatisporolide A exhibits antibacterial activity against Escherichia coli in vitro. Striatisporolide A damages the cell wall and cell membrane of Escherichia coli, and induces changes in protein levels and morphology. Striatisporolide A reduces the level of apoptosis (apoptosis) in HUVECs, inhibits excessive production of ROS, and possesses pro-proliferative and mild cytoprotective effects. Striatisporolide A can be used in studies related to bacterial infections and degenerative diseases .

HY-N17858

Guajaphenone A	Structural Classification Psidium guajava Linn. Phenols Polyphenols Myrtaceae Plants Source Classification	Bacterial
Guajaphenone A is a benzophenone glycoside antibacterial agent that can be found in the leaves of Psidium guajava L. Guajaphenone A inhibits the growth of Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Guajaphenone A is applicable to research related to bacterial infections .

HY-N12752

(-)-Casbene Casbene	Structural Classification Ricinus communis L. Terpenoids Diterpenoids Euphorbiaceae Plants Source Classification	Bacterial Fungal
(-)-Casbene (Casbene) is an antimicrobial agent that can be found in Euphorbiaceae plants. (-)-Casbene retards Aspergillus niger development, and inhibits Escherichia coli growth. (-)-Casbene can be used for the research of bacterial and fungal infection .

HY-W166491

Citronellyl butyrate	Structural Classification Pelargonium roseum Willd. Ketones, Aldehydes, Acids Plants Geraniaceae Source Classification	Bacterial Fungal
Citronellyl butyrate is a terpenoid ester with antibacterial, antifungal and other biological activities. Citronellyl butyrate has inhibitory effects on both Staphylococcus aureus and Escherichia coli. Citronellyl butyrate has inhibitory and bactericidal effects on various strains of Candida albicans (MIC: 156-1250 μg/mL). Citronellyl butyrate can be used in the research of infectious conditions .

HY-W009886R

3,4,5-Trimethoxybenzaldehyde (Standard)	Clerodendrum trichotomum Thunb. Structural Classification Ketones, Aldehydes, Acids Verbenaceae Plants Source Classification	Bacterial Reference Standards Drug Intermediate
3,4,5-Trimethoxybenzaldehyde (Standard) is the analytical standard of 3,4,5-Trimethoxybenzaldehyde (HY-W009886). This product is intended for research and analytical applications. 3,4,5-Trimethoxybenzaldehyde is a derivative of benzaldehyde. 3,4,5-Trimethoxybenzaldehyde has antimicrobial activity. 3,4,5-Trimethoxybenzaldehyde is also an important intermediate for the synthesis of various drugs, such as Trimethoprim (HY-B0510) .

HY-N18194

Ducloudine C	Structural Classification Alkaloids Other Alkaloids Ranunculaceae Plants Aconitum nagarum var. acaule (Finet & Gagnep.) Q. E. Yang Source Classification	Fungal
Ducloudine C is an alkaloid present in the roots of Aconitum duclouxii with antifungal activity. Ducloudine C has an MIC of 128 μg/mL against Candida albicans .

HY-N18080

Parthenin	Structural Classification Terpenoids Sesquiterpenes Antheroporum pierrei Gagnep. Plants Compositae Source Classification	Parasite DNA Alkylator/Crosslinker Bacterial
Parthenin is a pseudoguaianolide-type sesquiterpene lactone present in Parthenium hysterophorus L. Parthenin induces chromosomal aberrations, mainly chromatid breaks, in human peripheral blood lymphocytes. Parthenin exhibits toxicity against Salmonella typhimurium and Escherichia coli strains, with reduced toxicity in the presence of a metabolic activation system (S9). Parthenin acts as an antifeedant against the 6th instar larvae of the tobacco cutworm (Spodoptera litura). Parthenin shows insecticidal activity against adult cowpea weevils (Callosobruchus maculatus). Parthenin inhibits seed germination and seedling growth of sicklepod (Cassia tora). Parthenin possesses nematicidal activity against the 2nd instar larvae of the southern root-knot nematode (Meloidogyne incognita). Parthenin serves as a research agent for studies related to cancer, malaria, amoebiasis, inflammatory diseases, and bacterial infections .

HY-N18007

3-Hydroxyglabrol	Structural Classification Flavanonols Glycyrrhiza glabra Linn. Flavonoids Leguminosae Plants Source Classification	Bacterial
3-Hydroxyglabrol is an Antibacterial agent. 3-Hydroxyglabrol can be isolated from Glycyrrhiza glabra L. var. typica. 3-Hydroxyglabrol inhibits the growth of Staphylococcus aureus (ATCC 13709) and Mycobacterium smegmatis (ATCC 607), with a MIC of 6.25 mcg/mL. 3-Hydroxyglabrol can be used for the research of Staphylococcus aureus infection, Mycobacterium smegmatis infection .

HY-N17734

2-Deethoxy-2-hydroxyphantomolin	Structural Classification Other Monoterpenes Terpenoids Plants Boraginaceae Source Classification	Bacterial Fungal
2-Deethoxy-2-hydroxyphantomolin, Germacranolide, is an Antifungal and Antibacterial agent. 2-Deethoxy-2-hydroxyphantomolin can be isolated from Elephantopus tomentosus Linn and E. mollis. 2-Deethoxy-2-hydroxyphantomolin is moderately active against Candida albicans (14 mm clearing zone) and slightly active against Escherichia coli (12 mm), Pseudomonas aeruginosa (12 mm), Bacillus subtilis (14 mm), and Trichophyton mentagrophytes (13 mm) .

HY-N10342

Cajanol	Structural Classification Flavonoids Leguminosae Phenols Polyphenols Plants Isoflavones Cajanus cajan (L.) Millsp. Source Classification	Apoptosis Bcl-2 Family Caspase PARP Reactive Oxygen Species (ROS) Bacterial PI3K Akt NF-κB P-glycoprotein
Cajanol is an isoflavanone that can be isolated from the roots of Cajanus cajan (L.) Millsp. . Cajanol inhibits cancer cell proliferation and induces cancer cell apoptosis. Cajanol promotes the expression of Bax, inhibits the expression of Bcl-2, activates caspase-9 and caspase-3, induces PARP cleavage, arrests the cell cycle at the G2/M phase, generates ROS, disrupts mitochondrial membrane potential and triggers cytochrome c release. Cajanol induces bacterial DNA damage, disrupts bacterial cell membranes, and exerts antibacterial activity in vitro. Cajanol reduces the expression of PI3K, inhibits the phosphorylation of Akt and NF-κB, downregulates the expression and transport function of P-gp, restores the sensitivity of drug-resistant cancer cells to Paclitaxel, and inhibits the growth of Paclitaxel-resistant metastatic ovarian tumors. Cajanol is applicable to research related to breast cancer, ovarian cancer and bacterial infections .

HY-W142206

Cyclopent-4-ene-1,3-dione	Structural Classification Ketones, Aldehydes, Acids Myrtaceae Plants Acca sellowiana (O. Berg) Burret Source Classification	Fungal
Cyclopent-4-ene-1,3-dione is a potent antifungal inhibitor of chitin synthesis. Cyclopent-4-ene-1,3-dione is potently antifungal against human pathogenic Candida species (IC₅₀ = 1-2 μM). Cyclopent-4-ene-1,3-dione is detected in feijoa cultivars with high antifungal bioactivity. Cyclopent-4-ene-1,3-dione can be used for the research of fungal infections .

Cat. No.	Product Name	Chemical Structure

HY-Y1718S

Tridecanoic acid-d2
Tridecanoic acid-d₂ is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .

HY-Y1718S1

Tridecanoic acid-d25
Tridecanoic acid-d₂₅ is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .

HY-B0960S

Sulfabenzamide-d4

Sulfabenzamide (N-Sulfanilylbenzamide)-d₄ is the deuterium labeled Sulfabenzamide (HY-B0960). Sulfabenzamide is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections .

HY-W743473

Cefetamet-d3

Cefetamet-d₃ (Ro 15-8074-d₃; Deacetoxycefotaxime-d₃) is the deuterium labeled Cefetamet (HY-A0111). Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC₅₀ for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis .

HY-B0333S

Sulfamethizole-d4

Sulfamethizole-d₄ is the deuterium labeled Sulfamethizole (HY-B0333). Sulfamethizole is a sulfathiazole antibiotic. Sulfamethizole inhibits the synthesis of folic acid and thymine, and selectively suppresses Photobacterium phosphoreum bioluminescence. Sulfamethizole exerts antibacterial activity against Escherichia coli-mediated urinary tract infections but no activity against sulII gene-positive Escherichia coli. Sulfamethizole is applicable for the research of urinary tract infections and Photobacterium phosphoreum bioluminescence mechanisms .

HY-B0333S2

Sulfamethizole-d4-1

Sulfamethizole-d₄-1 is the deuterium labeled Sulfamethizole (HY-B0333). Sulfamethizole is a sulfathiazole antibiotic. Sulfamethizole inhibits the synthesis of folic acid and thymine, and selectively suppresses Photobacterium phosphoreum bioluminescence. Sulfamethizole exerts antibacterial activity against Escherichia coli-mediated urinary tract infections but no activity against sulII gene-positive Escherichia coli. Sulfamethizole is applicable for the research of urinary tract infections and Photobacterium phosphoreum bioluminescence mechanisms .

HY-W011117S

Danofloxacin-d3
Danofloxacin-d₃ is deuterium labeled Danofloxacin. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

HY-W011117S1

Danofloxacin-d3-1
Danofloxacin-d3-1 is deuterium labeled Danofloxacin. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

HY-Y1718S2

Tridecanoic acid-d9
Tridecanoic acid-d₉ is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .

HY-B1415S

Clofibric acid-d4

Clofibric acid-d₄ is the deuterium labeled Clofibric acid (HY-B1415). Clofibric acid also is an herbicideClofibric acid (Chlorofibrinic acid) is an orally active PPARα agonist. Clofibric acid inhibits the fimbriation of Escherichia coli. Clofibric acid increases SOD activity. Clofibric acid lowers blood lipids and prevents experimental pyelonephritis. Clofibric acid has anticancer activity against ovarian cancer. Clofibric acid is also a herbicide. Clofibric acid is used in ovarian cancer, liver cancer, obesity, and urinary tract infection research .

HY-B0147S1

Pefloxacin-d3

Pefloxacin-d₃ (Pefloxacinium-d₃) is the deuterium labeled Pefloxacin (HY-B0147). Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-B0147S

Pefloxacin-d5

Pefloxacin-d₅ (Pefloxacinium-d₅) is the deuterium labeled Pefloxacin (HY-B0147). Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-N7101S

Cefpodoxime proxetil-d7

Cefpodoxime proxetil-d7 (U-76-d7,252-d7; CS-807-d7) is the deuterium labeled Cefpodoxime Proxetil (HY-N7101). Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .

Cat. No.	Product Name		Classification

HY-170333

Lipid A-11 CICL1		Cationic Lipids
Lipid A-11 (Compound A-11) (CICL1) is an ionizable cationic lipid. Lipid A-11 can be used to prepare lipid nanoparticles. Lipid A-11 can be used in research involving T cell-targeted transfection .

HY-152296

8-Methyladenosine		Nucleoside Analogs Adenosine
8-Methyladenosine is a modified adenosine nucleoside. Through methylation at the 8-position, 8-Methyladenosine confers bacterial resistance to five classes of antibiotics that bind to the ribosomal peptidyl transferase center. 8-Methyladenosine can be used in studies of antibiotic-resistant bacterial infections .

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