LpxC-IN-17
LpxC-IN-17 (Compound a5) is a non-covalent LpxC inhibitor and Antibacterial agent. LpxC-IN-17 chelates catalytic zinc ions and forms extensive non-covalent interactions within the LpxC active site, thereby functionally inhibiting the enzyme. LpxC-IN-17 exhibits antibacterial activity against Gram-negative pathogens including Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. LpxC-IN-17 is applicable to research related to Gram-negative bacterial infections.
For research use only. We do not sell to patients.
- Formula: C22H21N5O3
- Molecular Weight:403.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
LpxC-IN-17 exhibits pronounced antibacterial activity against
Escherichia coli (MICs: 0.06-0.25 μg/mL), Klebsiella pneumoniae (MICs: 1-16
μg/mL), and Pseudomonas aeruginosa (MICs: 1-4 μg/mL).[1].
LpxC-IN-17 exhibits low cytotoxicity against A549 and HepG2 cells (IC50 >10 μM), and moderate cytotoxicity against HEK293 cells (IC50 = 2.260 ± 0.8583 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 403.43
-
Formula C22H21N5O3
-
SMILES
O=C(N[C@@H](CN1N=NC(C2CC2)=C1)C(NO)=O)C3=CC=C(C#CC#CC4CC4)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LpxC-IN-17 Related Classifications
HY-181892 Related Classifications
Powered by Bioz