2. Anti-infection
  3. Bacterial
  4. LpxC-IN-17

LpxC-IN-17 (Compound a5) is a non-covalent LpxC inhibitor and Antibacterial agent. LpxC-IN-17 chelates catalytic zinc ions and forms extensive non-covalent interactions within the LpxC active site, thereby functionally inhibiting the enzyme. LpxC-IN-17 exhibits antibacterial activity against Gram-negative pathogens including Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. LpxC-IN-17 is applicable to research related to Gram-negative bacterial infections.

For research use only. We do not sell to patients.

LpxC-IN-17

LpxC-IN-17 Chemical Structure

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LpxC-IN-17 Related Antibodies

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Description

LpxC-IN-17 (Compound a5) is a non-covalent LpxC inhibitor and Antibacterial agent. LpxC-IN-17 chelates catalytic zinc ions and forms extensive non-covalent interactions within the LpxC active site, thereby functionally inhibiting the enzyme. LpxC-IN-17 exhibits antibacterial activity against Gram-negative pathogens including Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. LpxC-IN-17 is applicable to research related to Gram-negative bacterial infections[1].

In Vitro

LpxC-IN-17 exhibits pronounced antibacterial activity against
Escherichia coli (MICs: 0.06-0.25 μg/mL), Klebsiella pneumoniae (MICs: 1-16
μg/mL), and Pseudomonas aeruginosa (MICs: 1-4 μg/mL).[1].
LpxC-IN-17 exhibits low cytotoxicity against A549 and HepG2 cells (IC50 >10 μM), and moderate cytotoxicity against HEK293 cells (IC50 = 2.260 ± 0.8583 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LpxC-IN-17 Related Antibodies
Molecular Weight

403.43

Formula

C22H21N5O3
SMILES

O=C(N[C@@H](CN1N=NC(C2CC2)=C1)C(NO)=O)C3=CC=C(C#CC#CC4CC4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LpxC-IN-17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LpxC-IN-17BacterialUDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylasegram-negative bacterial infectionsEscherichia coliLpxCPseudomonas aeruginosaHepG2HEK293Gram-negative pathogensKlebsiella pneumoniaeA549Inhibitorinhibitorinhibit

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HY-181892
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