Antibacterial agent 271

Antibacterial agent 271 (Compound 11c) has an outstanding inhibitory effect on Escherichia coli (MIC: 2.2 μM), and exhibits strong inhibitory effects on other Gram-negative bacteria (Pseudomonas aeruginosa MIC: 17.6 μM) and some Gram-positive bacteria (Staphylococcus aureus MIC: 8.8 μM and Enterococcus faecalis MIC: 4.4 μM)^[1].
Antibacterial agent 271 (2.2 μM-8.8 μM, 4 h) can completely inhibit bacterial growth at 2.2 μM, indicating that it has a good ability to quickly inhibit the growth of Escherichia coli^[1].
Antibacterial agent 271 demonstrates stable MIC values against Escherichia coli after 16 generations of passage experiments, indicating a low risk of resistance development^[1].
Antibacterial agent 271 (0.5632 mM, 24 h) exhibits low hemolytic activity in human red blood cells (RBC)^[1].
Antibacterial agent 271 (40 μM) shows very low cytotoxicity to normal human liver cells (LO2) and breast cancer cells (MCF-7) (cell survival rate > 85%)^[1].
Antibacterial agent 271 (2.2 μM -35.2 μM) causes membrane potential imbalance, outer membrane destruction, inner membrane damage and protein leakage in Escherichia coli^[1].
Antibacterial agent 271 (2.2 μM -35.2 μM) inhibits the metabolic activity of Escherichia coli, resulting in loss of cell viability, and induces ROS production in Escherichia coli, thereby inhibiting bacterial growth^[1].
Antibacterial agent 271 (2.2 μM -35.2 μM) interacts with DNA through groove binding, inhibits replication but does not cut DNA, and ultimately destroys the normal biological functions of bacteria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.