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  3. Bacterial
  4. N-Octanoyl-L-homoserine lactone

N-Octanoyl-L-homoserine lactone  (Synonyms: C8-HSL)

Cat. No.: HY-124237A Pureté: 99.40%
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N-Octanoyl-L-homoserine lactone is an autoinducer. It mainly serves as a key inter- and intra-species communication medium or "signal molecule" in Gram-negative bacteria. N-Octanoyl-L-homoserine lactone microparticles exhibit adjuvant potential when used in combination with various particulate vaccines.

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N-Octanoyl-L-homoserine lactone

N-Octanoyl-L-homoserine lactone Chemical Structure

CAS No. : 147852-84-4

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg   Obtenir un devis  
200 mg   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

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Other Forms of N-Octanoyl-L-homoserine lactone:

N-Octanoyl-L-homoserine lactone Related Antibodies

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Description

N-Octanoyl-L-homoserine lactone is an autoinducer. It mainly serves as a key inter- and intra-species communication medium or "signal molecule" in Gram-negative bacteria. N-Octanoyl-L-homoserine lactone microparticles exhibit adjuvant potential when used in combination with various particulate vaccines[1].

In Vitro

N-Octanoyl-L-homoserine lactone microspheres (20-200 µg/mL; 24 h) show no cytotoxicity against dendritic 2.4 cells[1].
N-Octanoyl-L-homoserine lactone microspheres (20-500 µg/mL; 24 h) induce nitric oxide release from dendritic 2.4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Octanoyl-L-homoserine lactone Related Antibodies
Masse moléculaire

227.30

Formule

C12H21NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC(N[C@@H]1C(OCC1)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (439.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3995 mL 21.9974 mL 43.9947 mL
5 mM 0.8799 mL 4.3995 mL 8.7989 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (11.00 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (11.00 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3995 mL 21.9974 mL 43.9947 mL 109.9868 mL
5 mM 0.8799 mL 4.3995 mL 8.7989 mL 21.9974 mL
10 mM 0.4399 mL 2.1997 mL 4.3995 mL 10.9987 mL
15 mM 0.2933 mL 1.4665 mL 2.9330 mL 7.3325 mL
20 mM 0.2200 mL 1.0999 mL 2.1997 mL 5.4993 mL
25 mM 0.1760 mL 0.8799 mL 1.7598 mL 4.3995 mL
30 mM 0.1466 mL 0.7332 mL 1.4665 mL 3.6662 mL
40 mM 0.1100 mL 0.5499 mL 1.0999 mL 2.7497 mL
50 mM 0.0880 mL 0.4399 mL 0.8799 mL 2.1997 mL
60 mM 0.0733 mL 0.3666 mL 0.7332 mL 1.8331 mL
80 mM 0.0550 mL 0.2750 mL 0.5499 mL 1.3748 mL
100 mM 0.0440 mL 0.2200 mL 0.4399 mL 1.0999 mL
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N-Octanoyl-L-homoserine lactone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Octanoyl-L-homoserine lactone147852-84-4C8-HSLBacterialdendritic cellsdendritic 2.4 cellszika virus infectionVibrio fischerimeaslesLuxRinfluenzaenterotoxigenic escherichia coli infectionanthraxlux operonInhibitorinhibitorinhibit

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