1. Antibody-drug Conjugate/ADC Related
    Anti-infection
  2. ADC Linker
    Bacterial
  3. N-Butanoyl-L-homoserine lactone

N-Butanoyl-L-homoserine lactone  (Synonyms: C4-HSL; N-Butyryl-L-homoserine lactone)

Cat. No.: HY-114816 Purity: ≥98.0%
COA Handling Instructions

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.

For research use only. We do not sell to patients.

N-Butanoyl-L-homoserine lactone Chemical Structure

N-Butanoyl-L-homoserine lactone Chemical Structure

CAS No. : 67605-85-0

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50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 90 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of N-Butanoyl-L-homoserine lactone:

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  • Purity & Documentation

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Description

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].

IC50 & Target[1]

Cleavable

 

In Vitro

The dissociation constant (Kd value) of aptamer binding to N-Butanoyl-L-homoserine lactone (C4-HSL) is 28.47 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

171.19

Formula

C8H13NO3

CAS No.
SMILES

CCCC(N[[email protected]]1CCOC1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (584.15 mM; Need ultrasonic)

H2O : 20 mg/mL (116.83 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8415 mL 29.2073 mL 58.4146 mL
5 mM 1.1683 mL 5.8415 mL 11.6829 mL
10 mM 0.5841 mL 2.9207 mL 5.8415 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
N-Butanoyl-L-homoserine lactone
Cat. No.:
HY-114816
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