Cyclopent-4-ene-1,3-dione
Cyclopent-4-ene-1,3-dione is a potent antifungal inhibitor of chitin synthesis. Cyclopent-4-ene-1,3-dione is potently antifungal against human pathogenic Candida species (IC50 = 1-2 μM). Cyclopent-4-ene-1,3-dione is detected in feijoa cultivars with high antifungal bioactivity. Cyclopent-4-ene-1,3-dione can be used for the research of fungal infections.
For research use only. We do not sell to patients.
- CAS No.: 930-60-9
- Formula: C5H4O2
- Molecular Weight:96.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Cyclopent-4-ene-1,3-dione (14 h) potently inhibits growth of S. cerevisiae and human pathogenic Candida species (C. albicans, C. glabrata, C. parapsilosis, C. tropicalis) (IC50 = 1.3-2.3 μM)[1].
Cyclopent-4-ene-1,3-dione targets chitin synthase genes CHS1 and CHS2 in Saccharomyces cerevisiae, as heterozygous deletion strains are hypersensitive and haploid deletion strains are resistant[1].
Cyclopent-4-ene-1,3-dione reduces chitin abundance in the septum of yeast cells[1].
Cyclopent-4-ene-1,3-dione exhibits 22-70-fold reduced antibacterial activity (IC50 = 33-105 μM) against Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus compared to its antifungal activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 930-60-9
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Molecular Weight 96.08
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Formula C5H4O2
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SMILES
O=C1C=CC(=O)C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyclopent-4-ene-1,3-dione Related Classifications
HY-W142206 Related Classifications
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- Cyclopent-4-ene-1,3-dione
- 930-60-9
- Fungal
- Bacillus subtilis
- C. tropicalis
- C. albicans
- C. parapsilosis
- human pathogenic Candida species
- Klebsiella pneumoniae
- fungal infections
- C. glabrata
- Saccharomyces cerevisiae
- CHS2
- chitin
- feijoa cultivars
- S. cerevisiae
- fungal cell wall polysaccharide
- chitin synthase genes CHS1
- chitin synthesis inhibitor
- Escherichia coli
- methicillin-resistant Staphylococcus aureus
- Inhibitor
- inhibitor
- inhibit