WLBU2 acetate
Based on 1 Customer Validation
WLBU2 acetate is a engineered cationic antimicrobial peptide (eCAP) that overcomes the environmental sensitivity of natural antimicrobial peptides (AMPs). WLBU2 acetate exhibits rapid bactericidal effect, with the MIC values of ≤ 10 μM against both Gram-negative and Gram-positive bacteria including MRSA, vancomycin-resistant enterococci, K. pneumoniae, E.aerogenes, E. cloacae, Escherichia coli, et, al. WLBU2 acetate prevents P. aeruginosa biofilm growth and retains its activity in an environment rich in mucus, low pH and high salt concentrations without negative effects on human airway epithelial cells. WLBU2 acetate can be used for the studies of cystic fibrosis (CF) and Pseudomonas aeruginosa infections.
For research use only. We do not sell to patients.
- Purity: 99.82%
- Formula: C151H260N66O25·xC2H4O2
- Molecular Weight:3400.11 (free base)
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
WLBU2 (5-90 μM, 24 h (abiotic surface); 10-100 μM, 5 h (CFAECs)) acetate prevents abiotic P. aeruginosa biofilms on an abiotic surface and on human cystic fibrosis airway epithelial cells (CFAECs)[1].
WLBU2 (50 μM, 5 h) acetate retains biofilm prevention activity in high salt (100 mM Nacl) and low pH (6.5-7.0) environments in CFAECs[1].
WLBU2 (20 μM, 5 h) acetate shows synergistic effect when combined with Tobramycin (HY-B0441), ciprofloxacin (HY-B0356), Ceftazidime (HY-B0593), and Meropenem (HY-13678), but has no synergistic effect with Colistin (HY-113678) in CFAECs[1].
WLBU2 acetate exhibits a MIC value of 7.943 μM against Klebsiella pneumoniae and a MIC value of 7.484 μM against clinical isolates of Acinetobacter baumannii, with the MBC values of the bacterial isolates being identical to their respective MIC values, indicating its bactericidal effect[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Appearance Solid
-
Molecular Weight 3400.11 (free base)
-
Formula C151H260N66O25·xC2H4O2
-
Color White to off-white
-
Sequence
Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-Arg-Val-Val-Arg-Arg-Trp-Val-Arg-Arg
-
Sequence Shortening
RRWVRRVRRWVRRVVRVVRRWVRR
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
-
Data Sheet (281 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)