MMV675968 

MMV675968 is an inhibitor of Acinetobacter baumannii dihydrofolate reductase (AbDHFR) with an IC₅₀ of 8.5 nM, and it exhibits selectivity against human DHFR. MMV675968 inhibits dihydrofolate reductase in Cryptosporidium, Plasmodium, and Escherichia coli, disrupting the thymidylate cycle and folate biosynthesis pathway. MMV675968 inhibits the growth of multiple A. baumannii strains, including clinical isolates and environmental isolates. MMV675968 is applicable to research related to A. baumannii infections^[1].

MMV675968 selectively inhibits A. baumannii DHFR but not human DHFR, with an IC₅₀ of 8.5 nM against A. baumannii DHFR and an IC₅₀ of 492.4 nM against human DHFR^[1].
MMV675968 (0.6-10 μM; 18 h) inhibits the growth of Acinetobacter baumannii (A. baumannii) strains Mahidol, Naval-81, H72721 and 3-137, with IC₅₀ values of 0.6-2.7 μM, IC₉₀ values of 0.7-3.9 μM, and MIC values of 1.6-10 μM^[1].
MMV675968 (10 μM; 18 h) inhibits the growth of E. coli PA414 surrogate cells expressing A. baumannii DHFR, but exerts no such effect on these cells expressing human DHFR^[1].
MMV675968 (10 μM; 90 min) inhibits endogenous DHFR activity in Acinetobacter baumannii strains Mahidol, Naval-81, H72721, and 3-137^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

359.81

C₁₇H₁₈ClN₅O₂

159308-73-3

ClC1=C2C(N)=NC(N)=NC2=CC=C1CNC3=CC(OC)=CC=C3OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Songsungthong W, et al. Diaminoquinazoline MMV675968 from Pathogen Box inhibits Acinetobacter baumannii growth through targeting of dihydrofolate reductase. Sci Rep. 2019;9(1):15625. Published 2019 Oct 30.