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Cat. No.: HY-182020

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LpxH-IN-3

LpxH-IN-3 is a Klebsiella pneumoniae LpxH inhibitor with an IC₅₀ of 0.17 μM. LpxH-IN-3 binds to the L-shaped hydrophobic binding pocket of Klebsiella pneumoniae LpxH, forms hydrogen bonds and other interactions with key residues, disrupts lipid A biosynthesis, and induces bacterial death. LpxH-IN-3 exhibits moderate antibacterial activity against Klebsiella pneumoniae and Escherichia coli. LpxH-IN-3 can be used for the research of klebsiella pneumoniae infection.

For research use only. We do not sell to patients.

Formula: C₂₇H₂₈Cl₂N₄O₄S
Molecular Weight:575.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LpxH-IN-3 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

In Vitro

LpxH-IN-3 (Compound 7) (0.0001-100 μM; 1 μM) potently inhibits purified Klebsiella pneumoniae LpxH with an IC₅₀ of 0.17 μM, achieving 81% inhibition at a concentration of 1 μM^[1].
LpxH-IN-3 (0.06-128 μg/mL; 18-24 h) exhibits moderate antibacterial activity against wild-type Klebsiella pneumoniae ATCC 10031 with an MIC of 5.3 μg/mL, and enhanced activity against outer membrane-defective and efflux-defective Escherichia coli mutants with MICs of 0.25 μg/mL and 0.5 μg/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 575.51
Formula C₂₇H₂₈Cl₂N₄O₄S
SMILES

CN(C1=C(C=CC=C1)C(NC2=CC=C(C=C2)CC(N3CCN(CC3)C4=CC(Cl)=CC(Cl)=C4)=O)=O)S(C)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang G, et al. Structure-Based Discovery of a New LpxH-Targeted Chemotype with Activity against Klebsiella pneumoniae. J Med Chem. 2026 Mar 26;69(6):6691-6705. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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