Sodium diacetate
Based on 1 Customer Validation
Sodium diacetate (Sodium hydrogen diacetate) is a multifunctional biochemical reagent with antibacterial (bacteria) and antifungal (fungi) activities. Sodium diacetate exerts its antimicrobial effect mainly by effectively penetrating the cell walls of microorganisms and interfering with enzyme interactions. Sodium diacetate inhibits the growth and survival of fungi such as Botrytis cinerea, as well as bacteria such as Listeria and Escherichia coli. Sodium diacetate inhibits the growth of endothelial cells. Sodium diacetate can be used in the synthesis of food preservatives, flavoring agents and pH control additives.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.86%
- CAS 番号: 126-96-5
- 分子式: CH3COONa·CH3COOH
- 分子量:142.09
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保管条件:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Sodium diacetate (5-40 mM, > 100 mM; up to 72 h at 35°C) exhibits stronger growth inhibitory activity against Listeria monocytogenes strain Scott A in BHI broth within the pH range of 5.0-6.0 than Acetic acid (HY-Y0319) used alone; its MIC values are 5 mM at pH 4.7, 20 mM at pH 5.0, 30 mM at pH 5.5, and 40 mM at pH 6.0[1].
Sodium diacetate inhibits the growth of multiple pathogenic and spoilage bacteria including Escherichia coli, Pseudomonas fluorescens, Salmonella enteritidis, Shewanella putrefaciens, Bacillus cereus, and Listeria monocytogenes, but shows no inhibitory activity against Pseudomonas fragi, Yersinia enterocolitica, Enterococcus faecalis, Lactobacillus fermentum, and Staphylococcus aureus[1][3].
Sodium diacetate (SDA) (25-200 μM; 24-48 h) inhibits the growth of HUVECs in a dose- and time-dependent manner, with an IC50 of 485.82 µM at 24 h and 190.19 µM at 48 h[2].
Sodium diacetate (190.19 μM; 48 h) exhibits no apoptotic or necrotic effects in HUVECs, showing no nuclear damage, DNA fragmentation, ladder formation, and only negligible levels of apoptotic and necrotic cells[2].
Sodium diacetate (SDA) (1-5 g/L; up to 5 days) completely inhibits the in vitro mycelial growth of Botrytis cinerea at concentrations of 3 g/L and 5 g/L[4].
Sodium diacetate (1-5 g/L; 24 h) completely inhibits spore germination and germ tube growth of Botrytis cinerea after incubation at concentrations of 3 g/L and 5 g/L[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human Umbilical Vein Endothelial Cells (HUVECs)
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Concentration:25, 50, 100, 200 μM
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Incubation Time:24 h; 48 h
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Result:Decreased HUVEC growth in a dose- and time-dependent manner.
Exhibited an IC50 of 485.82 µM after 24 h of treatment.
Exhibited an IC50 of 190.19 µM after 48 h of treatment.
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Cell Line:Human Umbilical Vein Endothelial Cells (HUVECs)
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Concentration:190.19 μM
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Incubation Time:48 h
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Result:Showed no obvious chromatin fragmentation, DNA rings, or DNA ladder formation in cell nuclei.
Displayed normal cell morphology consistent with untreated cells, with no apoptotic features.
Exhibited no significant DNA fragmentation or smearing in treated HUVECs.
Detected only 2.70% early apoptotic, 4.12% late apoptotic, and 1.73% necrotic cells in treated HUVECs, with all percentages being negligible.
化学情報
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CAS 番号 126-96-5
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性状 Solid
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分子量 142.09
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分子式 CH3COONa·CH3COOH
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Color White to off-white
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SMILES
[CH3COONa.CH3COOH]
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別名
Sodium hydrogen diacetate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
溶剤 & 溶解度
体外:
H2O : 50 mg/mL (351.89 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.0378 mL | 35.1890 mL | 70.3779 mL | 175.9448 mL |
| 5 mM | 1.4076 mL | 7.0378 mL | 14.0756 mL | 35.1890 mL | |
| 10 mM | 0.7038 mL | 3.5189 mL | 7.0378 mL | 17.5945 mL | |
| 15 mM | 0.4692 mL | 2.3459 mL | 4.6919 mL | 11.7297 mL | |
| 20 mM | 0.3519 mL | 1.7594 mL | 3.5189 mL | 8.7972 mL | |
| 25 mM | 0.2815 mL | 1.4076 mL | 2.8151 mL | 7.0378 mL | |
| 30 mM | 0.2346 mL | 1.1730 mL | 2.3459 mL | 5.8648 mL | |
| 40 mM | 0.1759 mL | 0.8797 mL | 1.7594 mL | 4.3986 mL | |
| 50 mM | 0.1408 mL | 0.7038 mL | 1.4076 mL | 3.5189 mL | |
| 60 mM | 0.1173 mL | 0.5865 mL | 1.1730 mL | 2.9324 mL | |
| 80 mM | 0.0880 mL | 0.4399 mL | 0.8797 mL | 2.1993 mL | |
| 100 mM | 0.0704 mL | 0.3519 mL | 0.7038 mL | 1.7594 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium diacetate 関連分類
HY-W094710 関連分類
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