E-4441
E-4441 is an orally active Antibacterial agent. E-4441 exerts broad-spectrum in vitro antibacterial activity against Gram-positive bacteria and aerobic bacteria. E-4441 exhibits protective effects against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections. E-4441 can be used in the research of systemic bacterial infections (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 124668-12-8
- 分子式: C17H17F2N3O3
- 分子量:349.34
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
E-4441 (4 μg/mL) inhibits all anaerobic bacteria[1].
For 90% of Gram-positive bacterial isolates (Staphylococcus, Streptococcus, and Enterococcus faecalis), the minimum inhibitory concentration (MIC) of E-4441 (18 h) ranges from 0.12 to 1 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
E-4441 (serial twofold doses; p.o.; single dose) exhibits in vivo protective activity against systemic Escherichia coli HM-42 infection in mice, with an ED50 of 3.0 mg/kg following a single oral dose, identical to the ED50 of ciprofloxacin[1].
E-4441 (serial twofold doses; p.o.; single dose) exhibits in vivo protective activity against systemic Pseudomonas aeruginosa HS-116 infection in mice, with an ED50 of 71.7 mg/kg following a single oral dose, efficacy comparable to Ciprofloxacin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HC:CFLP (male, ~25 g, intraperitoneal challenge with 5× minimal lethal dose of Staphylococcus aureus HS-93)[1]
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Dosage:Serial twofold doses
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Administration:p.o.; single dose
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Result:Determined an ED50 of 14.7 mg/kg.
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Animal Model:HC:CFLP (male, ~25 g, intraperitoneal challenge with 5× minimal lethal dose of Escherichia coli HM-42)[1]
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Dosage:Serial twofold doses
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Administration:p.o.; single dose
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Result:Determined an ED50 of 3.0 mg/kg, matching the ED50 of ciprofloxacin.
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Animal Model:HC:CFLP (male, ~25 g, intraperitoneal challenge with 5× minimal lethal dose of Pseudomonas aeruginosa HS-116)[1]
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Dosage:Serial twofold doses
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Administration:p.o.; single dose
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Result:Determined an ED50 of 71.7 mg/kg, efficacy comparable to ciprofloxacin.
化学情報
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CAS 番号 124668-12-8
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分子量 349.34
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分子式 C17H17F2N3O3
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SMILES
O=C(O)C1=CN(C2=C(F)C(=C(F)C=C2C1=O)N3CC(N)(C)C3)C4CC4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
E-4441 関連分類
HY-116558 関連分類
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