ACP1-01
ACP1-01 is a bacterial ClpP activator with EC50s of 3.4 and 2.6 μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP). ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research.
For research use only. We do not sell to patients.
- CAS No.: 1382489-31-7
- Formula: C19H18F6N2O3S2
- Molecular Weight:500.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 1382489-31-7
-
Molecular Weight 500.48
-
Formula C19H18F6N2O3S2
-
SMILES
CC(C(NCCSC1=CC=CC=C1C(F)(F)F)=O)(S(=O)(C2=NC=C(C=C2)C(F)(F)F)=O)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025 Aug 5:S0969-2126(25)00261-8. [Content Brief]
[2]. Mabanglo MF, et al. ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. Commun Biol. 2019 Nov 13;2:410. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz