CCG-120304 

CCG-120304 is a TonB system inhibitor and bacteriostatic agent. CCG-120304 inhibits TonB-dependent functions. CCG-120304 is applicable to research related to urinary tract infections^[1].

CCG-120304 (0.39-100 μM; 16-20 h) inhibits growth of UPEC CFT073 ΔtolC::kan under iron-limiting conditions with an AC₅₀ of 11 μM, acts as a bacteriostatic agent without disrupting proton motive force, and its inhibitory effect is reversed by excess iron^[1].
CCG-120304 (0.39-100 μM; 16 h) specifically targets the TonB system in UPEC, as its growth inhibitory activity is abrogated in TonB-deficient strains and reversed by TonB overexpression^[1].
CCG-120304 (100 μM; 20 min) inhibits TonB-dependent function in E. coli, as demonstrated by its ability to block irreversible adsorption of the TonB-dependent bacteriophage λh₈₀ without affecting TonB-independent phage adsorption^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

294.35

C₁₉H₁₈O₃

854005-84-8

O=C1C(O)=C(OC2=CC=C(C=C21)C)C=3C=CC(=CC3)C(C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yep A, et al. Inhibitors of TonB function identified by a high-throughput screen for inhibitors of iron acquisition in uropathogenic Escherichia coli CFT073. mBio. 2014;5(2):e01089-13. Published 2014 Feb 25.  [Content Brief]