N-Nitrosovancomycin 

N-Nitrosovancomycin is an antibacterial agent and an N-terminal nitrosated derivative of vancomycin. N-Nitrosovancomycin exhibits antibacterial activity against Gram-positive bacteria in vitro, but shows no activity against Gram-negative E. coli. The modified N-terminal amino group of N-Nitrosovancomycin cannot be protonated, yet the compound still retains in vitro antibacterial activity. N-Nitrosovancomycin can be used in studies related to Gram-positive bacterial infections^[1][2].

N-Nitrosovancomycin (18-24 h) inhibits the growth of multiple Gram-positive clinical isolates in vitro, with MIC₅₀ values ranging from 4.00 to 8.00 μg/mL and MIC₉₀ values ranging from 4.00 to 16.00 μg/mL across the tested strains^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1478.25

C₆₆H₇₄Cl₂N₁₀O₂₅

155386-25-7

ClC1=CC([C@H]([C@H](C(N[C@H](C(N[C@@]2([H])C(N[C@]3([H])C4=CC=C(O)C(C5=C(O)C=C(O)C=C5[C@H](NC([C@](NC3=O)([H])[C@@H](C6=CC=C(O7)C(Cl)=C6)O)=O)C(O)=O)=C4)=O)=O)CC(N)=O)=O)NC([C@@H](CC(C)C)N(C)N=O)=O)O)=CC=C1OC8=C(C7=CC2=C8)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O[C@H]%10C[C@](N)([C@@H]([C@@H](O%10)C)O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhou QL, et al. Preparation method of N-nitroso-vancomycin, CN, CN120289581A, 2025-07-11.

  [2]. Pavlov AY, et al. Synthesis and biological activity of derivatives of glycopeptide antibiotics eremomycin and vancomycin nitrosated, acylated or carbamoylated at the N-terminal. J Antibiot (Tokyo). 1993;46(11):1731-1739.