N-Nitrosovancomycin
N-Nitrosovancomycin is an antibacterial agent and an N-terminal nitrosated derivative of vancomycin. N-Nitrosovancomycin exhibits antibacterial activity against Gram-positive bacteria in vitro, but shows no activity against Gram-negative E. coli. The modified N-terminal amino group of N-Nitrosovancomycin cannot be protonated, yet the compound still retains in vitro antibacterial activity. N-Nitrosovancomycin can be used in studies related to Gram-positive bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 155386-25-7
- Formula: C66H74Cl2N10O25
- Molecular Weight:1478.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
N-Nitrosovancomycin (18-24 h) inhibits the growth of multiple Gram-positive clinical isolates in vitro, with MIC50 values ranging from 4.00 to 8.00 μg/mL and MIC90 values ranging from 4.00 to 16.00 μg/mL across the tested strains[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 155386-25-7
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Molecular Weight 1478.25
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Formula C66H74Cl2N10O25
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SMILES
ClC1=CC([C@H]([C@H](C(N[C@H](C(N[C@@]2([H])C(N[C@]3([H])C4=CC=C(O)C(C5=C(O)C=C(O)C=C5[C@H](NC([C@](NC3=O)([H])[C@@H](C6=CC=C(O7)C(Cl)=C6)O)=O)C(O)=O)=C4)=O)=O)CC(N)=O)=O)NC([C@@H](CC(C)C)N(C)N=O)=O)O)=CC=C1OC8=C(C7=CC2=C8)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O[C@H]%10C[C@](N)([C@@H]([C@@H](O%10)C)O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhou QL, et al. Preparation method of N-nitroso-vancomycin, CN, CN120289581A, 2025-07-11.
[2]. Pavlov AY, et al. Synthesis and biological activity of derivatives of glycopeptide antibiotics eremomycin and vancomycin nitrosated, acylated or carbamoylated at the N-terminal. J Antibiot (Tokyo). 1993;46(11):1731-1739. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Nitrosovancomycin Related Classifications
Cat. No.: HY-182823
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- N-Nitrosovancomycin
- 155386-25-7
- Drug Derivative
- Bacterial
- gram-positive bacterial infections
- coagulase-negative staphylococci
- Gram-negative Escherichia coli
- HRMS
- 1H-NMR
- 13C-NMR
- methicillin-resistant Staphylococcus aureus
- Enterococcus species
- methicillin-sensitive Staphylococcus aureus
- Gram-positive bacteria
- Inhibitor
- inhibitor
- inhibit