155386-25-7
Chemical Structure
N-Nitrosovancomycin
- CAS No.: 155386-25-7
- Formula:C66H74Cl2N10O25
- Molecular Weight:1478.25
InChIKey: BQBWVAVIAXHHCG-FHYUGYJVSA-N
SMILES: ClC1=CC([C@H]([C@H](C(N[C@H](C(N[C@@]2([H])C(N[C@]3([H])C4=CC=C(O)C(C5=C(O)C=C(O)C=C5[C@H](NC([C@](NC3=O)([H])[C@@H](C6=CC=C(O7)C(Cl)=C6)O)=O)C(O)=O)=C4)=O)=O)CC(N)=O)=O)NC([C@@H](CC(C)C)N(C)N=O)=O)O)=CC=C1OC8=C(C7=CC2=C8)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O[C@H]%10C[C@](N)([C@@H]([C@@H](O%10)C)O)C
Biological Activity: N-Nitrosovancomycin is an antibacterial agent and an N-terminal nitrosated derivative of vancomycin. N-Nitrosovancomycin exhibits antibacterial activity against Gram-positive bacteria in vitro, but shows no activity against Gram-negative E. coli. The modified N-terminal amino group of N-Nitrosovancomycin cannot be protonated, yet the compound still retains in vitro antibacterial activity. N-Nitrosovancomycin can be used in studies related to Gram-positive bacterial infections[1][2].
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N-Nitrosovancomycin | N-Nitrosovancomycin is an antibacterial agent and an N-terminal nitrosated derivative of vancomycin. N-Nitrosovancomycin exhibits antibacterial activity against Gram-positive bacteria in vitro, but shows no activity against Gram-negative E. coli. The modified N-terminal amino group of N-Nitrosovancomycin cannot be protonated, yet the compound still retains in vitro antibacterial activity. N-Nitrosovancomycin can be used in studies related to Gram-positive bacterial infections. | |||||||||||||||||||||
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- [1]. Zhou QL, et al. Preparation method of N-nitroso-vancomycin, CN, CN120289581A, 2025-07-11.
- [2]. Pavlov AY, et al. Synthesis and biological activity of derivatives of glycopeptide antibiotics eremomycin and vancomycin nitrosated, acylated or carbamoylated at the N-terminal. J Antibiot (Tokyo). 1993;46(11):1731-1739. [Content Brief]
Keywords
