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CCL2/JE/MCP-1 Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Akt (6) AMPK (1) Amyloid-β (1) ANGPTL (1) Antibiotic (3) Antibody-Drug Conjugates (ADCs) (6) Apoptosis (14) Arginase (2) Bacterial (11) Bcl-2 Family (3) BMX Kinase (1) Btk (1) Calcium Channel (2) Cannabinoid Receptor (1) CaSR (1) CCR (28) CHIKV (1) Cholinesterase (ChE) (1) Complement System (1) COX (5) Discoidin Domain Receptor (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (3) Drug Intermediate (2) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (4) Epigenetic Reader Domain (8) ERK (2) FABP (3) Ferroptosis (1) FLT3 (1) Fungal (3) Glucocorticoid Receptor (5) Glycosidase (1) GSK-3 (1) HBV (1) Heme Oxygenase (HO) (1) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (7) HIV (1) HSP (1) Hydroxycarboxylic Acid Receptor (HCAR) (1) IFNAR (1) IMPDH (1) Integrin (1) Interleukin Related (39) Isotope-Labeled Compounds (5) Keap1-Nrf2 (2) Leukotriene Receptor (1) Liposome (1) Mas-related G-protein-coupled Receptor (MRGPR) (2) MDM-2/p53 (1) Melanocortin Receptor (1) Microtubule/Tubulin (4) Mineralocorticoid Receptor (4) Mitochondrial Metabolism (1) MMP (4) Molecular Glues (1) mRNA (2) NF-κB (20) NO Synthase (11) NOD-like Receptor (NLR) (3) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (7) p38 MAPK (3) Parasite (12) PGE synthase (1) Phospholipase (1) PI3K (4) PPAR (5) Prostaglandin Receptor (1) Protease Activated Receptor (PAR) (6) Pyruvate Kinase (2) Reactive Oxygen Species (ROS) (6) Reference Standards (15) SARS-CoV (1) SHP2 (1) Sirtuin (1) Small Interfering RNA (siRNA) (3) Src (1) STAT (5) Survivin (1) TGF-beta/Smad (6) Thrombin (2) TNF Receptor (22) Toll-like Receptor (TLR) (2) Topoisomerase (3) Transmembrane Glycoprotein (1) TRP Channel (1) Tyrosinase (1) VEGFR (5) Virus Protease (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (41) Cardiovascular Disease (10) Endocrinology (3) Infection (25) Inflammation/Immunology (110) Metabolic Disease (28) Neurological Disease (21)
Oligonucleotides:	Aptamers (3) Chemokine & Receptors (2) Rat Pre-designed siRNA Sets (1) Cationic Lipids (1) Mouse Pre-designed siRNA Sets (1) mRNA (2) Human Pre-designed siRNA Sets (1) siRNAs (3)

147

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0673

Pirfenidone Maximum Cited Publications 80 Publications Verification AMR69	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone (AMR69) is an antifibrotic agent that attenuates *CCL2* and *CCL12* production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces *TGF-β2* protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[1] ^[2] .

HY-125864

Fibrinogen (Bovine) 2 Publications Verification	Interleukin Related NF-κB	Inflammation/Immunology
Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines *MCP-1* and *MCP-1*. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases ^[1] ^[2] .

HY-B0498

Bindarit Maximum Cited Publications 29 Publications Verification AF2838	CCR	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23*. Bindarit also has anti-inflammatory activity ^[1].

HY-B1203

Fludrocortisone 9α-Fludrocortisone; 9α-Fluorcortisol	Mineralocorticoid Receptor Glucocorticoid Receptor Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Fludrocortisone (9α-Fludrocortisone) is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces *CCL2, IL-6, IL-8* levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, *ERK1/2, mTOR* phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced *MUC1* upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency ^[1] ^[2] .

HY-33037

Phenazine-1-carboxylic acid	Fungal	Infection Inflammation/Immunology Cancer
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation ^[1] ^[2] .

HY-P99188

Carlumab 4 Publications Verification CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) monoclonal antibody. Carlumab binds and neutralises profibrotic activities of human CCL2. Carlumab inhibits tumor growth by reducing macrophage infiltration and decreasing tumor microvascular density. Carlumab can be used for the research of cancer, suah as prostate cancer ^[1] ^[2].

HY-N3007

Naringenin chalcone 5+ Cited Publications	Drug Intermediate Apoptosis NO Synthase	Inflammation/Immunology Cancer
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of *MCP-1* and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties ^[1] ^[2] .

HY-112868B

ABH hydrochloride 1 Publications Verification	Arginase NO Synthase Integrin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
ABH (hydrochloride) is an orally active arginase inhibitor (K_i = 8.5 nM). ABH hydrochloride promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, *VCAM-1, MCP-1*). ABH hydrochloride improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis ^[1] ^[2] .

HY-N0847

Micheliolide 5+ Cited Publications	NF-κB PI3K Akt TGF-beta/Smad	Inflammation/Immunology Cancer
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis ^[1] ^[2] .

HY-N9914

D-Psicose D-Allulose	p38 MAPK NF-κB	Metabolic Disease
D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] ^[2] .

HY-P990297

*Anti-Mouse/Rat/Human CCL2/MCP-1* Antibody (2H5)** 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human *CCL2/MCP-1* IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV ^[1] ^[2] .

HY-N2572

Eupafolin Nepetin; 6-Methoxyluteolin	Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Eupafolin (Nepetin) (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Eupafolin inhibits IL-6, IL-8 and *MCP-1* secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells ^[1] ^[2].

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, *VCAM-1, MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces p-AMPK* and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis ^[1] ^[2] .

HY-12642

Diethylcarbamazine citrate 1 Publications Verification	Parasite Bacterial TNF Receptor Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Diethylcarbamazine citrate is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine citrate reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine citrate reduces serum levels of leptin, TNF-α, IL-6, *MCP-1*, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine citrate enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine citrate can be used for the researches of bronchial asthma, insulin resistance and infection ^[1] ^[2] .

HY-P99781

Plozalizumab MLN-1202	CCR	Inflammation/Immunology Cancer
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) ^[1] ^[2] .

HY-B0673R

Pirfenidone (Standard) AMR69 (Standard)	Reference Standards TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone (Standard) is the analytical standard of Pirfenidone. This product is intended for research and analytical applications. Pirfenidone (AMR69) is an antifibrotic agent that attenuates *CCL2* and *CCL12* production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces *TGF-β2* protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[1] ^[2] .

HY-114164G

Murine Thrombin	Thrombin Protease Activated Receptor (PAR) MMP VEGFR Epigenetic Reader Domain	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Murine Thrombin is a murine serine protease that plays a central role in blood coagulation. Murine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Murine Thrombin activates *PAR1, induces the production of MCP-1, MMP3* and VEGF in mouse intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Murine Thrombin activity increases significantly in paraoxon-induced status epilepticus ^[1] ^[2] .

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36	CCR	Inflammation/Immunology Cancer
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice ^[1] ^[2] .

HY-B1076

Medrysone 1 Publications Verification HMS; 6α-Methyl-11β-hydroxyprogesterone	VEGFR CCR STAT	Neurological Disease
Medrysone (HMS; 6α-Methyl-11β-hydroxyprogesterone) is a STAT6 modulator and M2 macrophage polarization inducer. Medrysone enhances IL-4-triggered STAT6 activation, upregulates the expression of M2 markers, and promotes the secretion of VEGF and *CCL2. Medrysone also enhances the pro-migratory activity of M2-like* macrophages toward endothelial cells. By regulating macrophage polarization and related repair pathways, Medrysone significantly promotes corneal wound repair in a rat mechanical injury model. Medrysone can be used for research related to corneal injury ^[1].

HY-B0673S1

Deupirfenidone LYT-100; AMR69-d₃	Isotope-Labeled Compounds	Others
Deupirfenidone-d₃ is the deuterium labeled Pirfenidone (HY-B0673). Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[1] ^[2] .

HY-103325

JTE-907	Cannabinoid Receptor TRP Channel Interleukin Related ANGPTL VEGFR	Metabolic Disease Inflammation/Immunology
JTE-907 is a selective and orally active cannabinoid *CB2* receptor inverse agonist and exerts anti-inflammatory effects. JTE-907 upregulates IL-6, *MCP-1, IL-1β,* VEGF, ANGPTL4, and *TRPV1* in mature adipocytes. JTE-907 downregulates *CB1, MCP-1, and IL-1β* in preadipocytes. JTE-907 inhibits ear swelling in mice. JTE-907 reverses the protective effects of CB2 agonists and Anandamide (HY-10863) against cytokine-evoked colonic mucosal damage. JTE-907 can be used for the research of allergic dermatitis, obesity, and colitis ^[1] ^[2] .

HY-110217

BMS-566419	IMPDH	Inflammation/Immunology
BMS-566419 is an orally active IMPDH inhibitor with an IC₅₀ of 91 nM against human IMPDH I and 68 nM against human IMPDH II. BMS-566419 exerts anti-heart transplant rejection and anti-renal fibrosis effects, and inhibits the expression of *MCP-1, TGF-β1* as well as antibody production. BMS-566419 can be used in research on renal fibrosis and organ transplantation ^[1] ^[2].

HY-108323

CCR2 antagonist 4 5+ Cited Publications Teijin compound 1	CCR	Inflammation/Immunology
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific *CCR2* antagonist, with IC₅₀s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC₅₀ of 24 nM ^[1].

HY-103362

CCR2 antagonist 4 hydrochloride 5+ Cited Publications Teijin compound 1 hydrochloride	CCR	Inflammation/Immunology
CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific *CCR2* antagonist, with IC₅₀s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC₅₀ of 24 nM ^[1].

HY-B0673S

Pirfenidone-d5 AMR69-d₅	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone-d₅ (AMR69-d₅) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[1] ^[2] .

HY-170415

EGR-1-IN-3	Interleukin Related	Inflammation/Immunology
EGR-1 IN-3 (Compound 36) is an early growth response 1 (EGR-1)-DNA binding disruptor. EGR-1-IN-3 inhibits TNFα-induced binding of *EGR-1* to DNA and expression of genes associated with inflammation (such as TSLP, IL-31, IL-6 and CCL2). EGR-1-IN-3 can be used in the study of inflammatory diseases ^[1].

HY-W013675

2-Methoxyhydroquinone	HSP	Inflammation/Immunology
2-Methoxyhydroquinone is a phenolic compound that reduces TNF-α-induced production of chemokine (C-C motif) ligand 2 (CCL2) with an IC₅₀ value of 64.3 µM. 2-Methoxyhydroquinone is also a precursor in the synthesis of the Hsp90 inhibitor Geldanamycin (HY-15230) ^[1] ^[2].

HY-P5523A

iE-DAP dihydrochloride	NOD-like Receptor (NLR) NF-κB Interleukin Related	Metabolic Disease
iE-DAP dihydrochloride is a *Nod1* agonist. iE-DAP dihydrochloride activates *NOD1, which in turn activates the NF-κB* signaling pathway and MLCK signaling pathway, inducing cellular inflammatory responses and tight junction disruption. iE-DAP dihydrochloride downregulates the expression of *ZO-1* and Occludin genes. iE-DAP dihydrochloride increases the secretion of IL-6, GRO-α, *MCP-1, IL-8* and *MIP-1β* in term human trophoblast cell cultures. iE-DAP dihydrochloride triggers preterm birth in pregnant mice, reduces fetal body weight, and induces fetal inflammation. iE-DAP dihydrochloride can be used in studies related to mastitis and preterm birth ^[1] ^[2].

HY-160552

244cis	Liposome	Others
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels ^[1].

HY-N1940

β-Anhydroicaritin 3 Publications Verification Cycloicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology Cancer
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties ^[1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats ^[2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-12642A

Diethylcarbamazine 1 Publications Verification	Parasite Bacterial TNF Receptor Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Diethylcarbamazine is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine reduces serum levels of leptin, TNF-α, IL-6, *MCP-1*, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine can be used for the researches of bronchial asthma, insulin resistance and infection ^[1] ^[2] .

HY-RS16514

Ccl2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl2 Mouse Pre-designed siRNA Set A Ccl2 Mouse Pre-designed siRNA Set A

HY-116247

ST247	PPAR	Metabolic Disease Inflammation/Immunology
ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ ^[1].

HY-148100A

Emapticap pegol sodium 1 Publications Verification NOX-E36 sodium	CCR	Cancer
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) ^[1] ^[2] .

HY-NP192

Sericin	Reactive Oxygen Species (ROS) Bacterial COX NO Synthase Toll-like Receptor (TLR) p38 MAPK NF-κB Interleukin Related Cholinesterase (ChE) Bcl-2 Family Tyrosinase PI3K Akt	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Sericin is an orally active globular protein produced by silkworm cocoons. Sericin inhibits the expression of *COX2, iNOS, TLR4, MAPK* and NF-κB; reduces the levels of IL-18, *IL-1* and *CCL2; antagonizes the activity of AChE; and downregulates the expression of Bcl-2. Sericin enhances the PI3K/AKT-mediated insulin signaling pathway. Sericin inhibits the activity of tyrosinase (Tyrosinase), scavenges ROS*, chelates metal ions, and increases the levels of antioxidant enzymes. Sericin induces apoptosis and arrests the cell cycle. Sericin exhibits antibacterial, moisturizing, cardioprotective and anticoagulant properties. Sericin can be used in research related to type 2 diabetes, hyperlipidemia, obesity, Alzheimer's disease, colon cancer, peripheral nerve injury and ischemic myocardial infarction ^[1] ^[2].

HY-P99149

Anti-Mouse TNFR2 Antibody (TR75-54.7)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse *TNFR2* IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer ^[1] ^[2].

HY-138623

GSK789	Epigenetic Reader Domain TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
GSK789 is a selective inhibitor of BET *BD1. GSK789 inhibits the growth of leukemia cell lines. GSK789 inhibits LPS-stimulated production of MCP-1, TNFα* and IL-6 in human whole blood. GSK789 exhibits antiproliferative, anti-inflammatory and immunomodulatory activities. GSK789 can be used in research related to cancers such as leukemia, as well as inflammatory and immune diseases ^[1].

HY-156025

HCAR2 agonist 1	Hydroxycarboxylic Acid Receptor (HCAR)	Inflammation/Immunology
HCAR2 agonist 1 (Compound 9n) is a G_i protein-biased allosteric modulator of *HCAR2. HCAR2 agonist 1 activates the G_i protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1*). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis ^[1].

HY-N9914R

D-Psicose (Standard) D-Allulose (Standard)	Reference Standards p38 MAPK NF-κB	Metabolic Disease
D-Psicose (Standard) is the analytical standard of D-Psicose (HY-N9914). This product is intended for research and analytical applications. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] ^[2] .

HY-125726

Sulfo galactosylceramide (3'-sulfo)Galβ-Cer(d18:1/24:1); N-Nervonoyl Sulfatide; C24:1 Sulfatide	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Sulfo galactosylceramide (N-Nervonoyl Sulfatide; C24:1 Sulfatide) is a glycolipid and the major sulfolipid species in mature myelin. Sulfo galactosylceramide interacts with C-type lectins and immunoglobulin-like receptors, with the highest affinity for LMIR5. Sulfo galactosylceramide induces MCP-1 production by basophils but not mast cells, and increases NFAT activation via LMIR5. Sulfo galactosylceramide alleviates symptoms and improves survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), and reduces inflammatory lesions and the number of infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.

HY-158990

GE1111	Mas-related G-protein-coupled Receptor (MRGPR) Interleukin Related TNF Receptor Akt ERK	Inflammation/Immunology
GE1111 is a *MRGPRX2* antagonist (IC₅₀ = 9.4 μM). GE1111 inhibits *MRGPRX2/MRGPRB2*-mediated mast cell activation. GE1111 reduces the expressions of TSLP, IL-13, *MCP-1, TNF-α, IL-1β* and periostin, maintains the expression levels of claudin 1 and involucrin, restores the phagocytic activity of macrophages, and attenuates the activation of *STIM1* and phosphorylated AKT. GE1111 exerts anti-inflammatory and anti-allergic effects in multiple animal models. GE1111 is applicable to the research related to rosacea, atopic dermatitis and ulcerative colitis ^[1] ^[2] .

HY-125864D

Rabbit Fibrinogen	Interleukin Related NF-κB	Cardiovascular Disease
Rabbit Fibrinogen is a native fibrinogen from rabbit plasma. Fibrinogen is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines *MCP-1* and *MCP-1*. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases ^[1] ^[2] .

HY-P991208

Flt-3L-Ig (hum/hum) human Flt3L; hFlt3L	FLT3 Interleukin Related CCR	Inflammation/Immunology
Flt-3L-Ig (hum/hum) (hFlt3L) is a Flt3 ligand. Flt-3L-Ig (hum/hum) enhances the release of inflammatory cytokines from myeloid cells and dendritic cells in BRGSF-CBC mice induced by OKT3. Flt-3L-Ig (hum/hum) increases the release of *IL-2, CCL2* and CXCL10 in an OKT3-dependent manner. Flt-3L-Ig (hum/hum) can be used in studies related to cytokine release syndrome. Flt-3L-Ig (hum/hum) can be used in studies related to psoriasis-like skin inflammation ^[1] ^[2].

HY-174763

*Human CCL2* mRNA**	mRNA	Inflammation/Immunology
Human CCL2 mRNA encodes the human C-C motif chemokine ligand 2 (CCL2) protein. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis.

HY-173463

Sirtuin modulator 8	Sirtuin	Metabolic Disease Inflammation/Immunology
Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. Sirtuin modulator 8 significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21). Sirtuin modulator 8 regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases (such as diabetes, obesity) and inflammatory diseases ^[1].

HY-121896

DSHN	SHP2	Cancer
DSHN is a potent small heterodimer partner (SHP) activator. DSHN inhibits Ccl2 expression and secretion by inhibiting p65 activation of Ccl2 promoter activity. DSHN can be used in research of cancer ^[1].

HY-RS02089

CCL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL2 Human Pre-designed siRNA Set A CCL2 Human Pre-designed siRNA Set A

HY-W104821

Rosolic acid	Keap1-Nrf2	Metabolic Disease
Rosolic Acid is an activator of *Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α* and *IL-1β) and apoptotic markers (CXCL10* and *CCL2*). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed ^[1].

HY-176255

TBK1 degrader-4	Molecular Glues Interleukin Related CCR	Inflammation/Immunology
TBK1 degrader-4 (Compound 30) is a molecular glue degrader targeting *TBK1. TBK1 degrader-4 effectively inhibits cyst growth, alleviates inflammation, and reduces the levels of pro-inflammatory factors such as Ccl2*, IFNβ, and IL-6. TBK1 degrader-4 is promising for research of autosomal dominant polycystic kidney disease (ADPKD) ^[1].

HY-178926

RAGE406R	CCR TNF Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology Endocrinology
RAGE406R is an orally active *RAGE-DIAPH1* interaction antagonist. RAGE406R can bind to ctRAGE and prevent the formation of the *RAGE-DIAPH1* complex and inhibit its interaction. RAGE406R can reduce the expression of *CCL2, TNF, and IL-6* in THP1 cells. RAGE406R suppresses delayed-type hypersensitivity in T2D mice. RAGE406R can be used for the study of diabetes ^[1].

Cat. No.	Product Name	Type

HY-125864

Fibrinogen (Bovine)

2 Publications Verification

Biochemical Assay Reagents

Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases ^[1] ^[2] .

HY-N9914

D-Psicose D-Allulose	Biochemical Assay Reagents
D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] ^[2] .

HY-NP192

Sericin

Biochemical Assay Reagents

Sericin is an orally active globular protein produced by silkworm cocoons. Sericin inhibits the expression of COX2, iNOS, TLR4, MAPK and NF-κB; reduces the levels of IL-18, IL-1 and CCL2; antagonizes the activity of AChE; and downregulates the expression of Bcl-2. Sericin enhances the PI3K/AKT-mediated insulin signaling pathway. Sericin inhibits the activity of tyrosinase (Tyrosinase), scavenges ROS, chelates metal ions, and increases the levels of antioxidant enzymes. Sericin induces apoptosis and arrests the cell cycle. Sericin exhibits antibacterial, moisturizing, cardioprotective and anticoagulant properties. Sericin can be used in research related to type 2 diabetes, hyperlipidemia, obesity, Alzheimer's disease, colon cancer, peripheral nerve injury and ischemic myocardial infarction ^[1] ^[2].

HY-N9914R

D-Psicose (Standard)

D-Allulose (Standard)

Biochemical Assay Reagents

D-Psicose (Standard) is the analytical standard of D-Psicose (HY-N9914). This product is intended for research and analytical applications. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] ^[2] .

HY-W104821

Rosolic acid	Biochemical Assay Reagents
Rosolic Acid is an activator of *Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α* and *IL-1β) and apoptotic markers (CXCL10* and *CCL2*). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed ^[1].

Cat. No.	Product Name	Target	Research Area

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, *VCAM-1, MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces p-AMPK* and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis ^[1] ^[2] .

HY-P5523A

iE-DAP dihydrochloride	NOD-like Receptor (NLR) NF-κB Interleukin Related	Metabolic Disease
iE-DAP dihydrochloride is a *Nod1* agonist. iE-DAP dihydrochloride activates *NOD1, which in turn activates the NF-κB* signaling pathway and MLCK signaling pathway, inducing cellular inflammatory responses and tight junction disruption. iE-DAP dihydrochloride downregulates the expression of *ZO-1* and Occludin genes. iE-DAP dihydrochloride increases the secretion of IL-6, GRO-α, *MCP-1, IL-8* and *MIP-1β* in term human trophoblast cell cultures. iE-DAP dihydrochloride triggers preterm birth in pregnant mice, reduces fetal body weight, and induces fetal inflammation. iE-DAP dihydrochloride can be used in studies related to mastitis and preterm birth ^[1] ^[2].

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced *IL‑6/MCP‑1* and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated *IRS‑1* in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation ^[1].

HY-P5523

iE-DAP	NOD-like Receptor (NLR) NF-κB Interleukin Related	Metabolic Disease
iE-DAP is a *Nod1* agonist. iE-DAP activates *NOD1, which in turn activates the NF-κB signaling pathway and MLCK signaling pathway, inducing cellular inflammatory responses and tight junction disruption. iE-DAP downregulates the expression of ZO-1* and Occludin genes. iE-DAP increases the secretion of IL-6, GRO-α, *MCP-1, IL-8* and *MIP-1β* in term human trophoblast cell cultures. iE-DAP triggers preterm birth in pregnant mice, reduces fetal body weight, and induces fetal inflammation. iE-DAP is applicable to research related to mastitis and preterm birth ^[1] ^[2].

HY-P11553

ECL1i	CCR	Inflammation/Immunology
ECL1i is an allosteric, selective *CCR2* inhibitor. ECL1i specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis ^[1].

HY-P11553A

ECL1i TFA	CCR	Infection Inflammation/Immunology
ECL1i TFA is an allosteric, selective *CCR2* inhibitor. ECL1i TFA specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i TFA interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis ^[1].

HY-144334

CHIKV-IN-3	CHIKV DNA/RNA Synthesis	Infection
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC₅₀ values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC₅₀>100 μM). Prophylactic effect ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor *ST2. Astegolimab reduces p53* expression, mitigates IL33-upregulated SASP factors such as *IL1α, IL6* and *MCP1. Astegolimab mitigates IL33-increased p-p65/p65* ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research ^[1] ^[2] .

HY-P99188

Carlumab 4 Publications Verification CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) monoclonal antibody. Carlumab binds and neutralises profibrotic activities of human CCL2. Carlumab inhibits tumor growth by reducing macrophage infiltration and decreasing tumor microvascular density. Carlumab can be used for the research of cancer, suah as prostate cancer ^[1] ^[2].

HY-P990297

*Anti-Mouse/Rat/Human CCL2/MCP-1* Antibody (2H5)** 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human *CCL2/MCP-1* IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV ^[1] ^[2] .

HY-P99781

Plozalizumab MLN-1202	CCR	Inflammation/Immunology Cancer
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) ^[1] ^[2] .

HY-P99450

Avdoralimab IPH 5401; Anti-C5aR1 mAb	Complement System	Inflammation/Immunology Cancer
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research ^[1].

HY-P991280

BMS-981164	Interleukin Related	Inflammation/Immunology
BMS-981164 is a human anti-IL31 IgG1-κ monoclonal antibody. BMS-981164 effectively inhibits the IL-31 signaling pathway. The isotype control of BMS-981164 can be referenced to Human IgG1 kappa, Isotype Control (HY-P99001). BMS-981164 is applicable to research related to atopic dermatitis ^[1].

HY-P99149

Anti-Mouse TNFR2 Antibody (TR75-54.7)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse *TNFR2* IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer ^[1] ^[2].

HY-P991208

Flt-3L-Ig (hum/hum) human Flt3L; hFlt3L	FLT3 Interleukin Related CCR	Inflammation/Immunology
Flt-3L-Ig (hum/hum) (hFlt3L) is a Flt3 ligand. Flt-3L-Ig (hum/hum) enhances the release of inflammatory cytokines from myeloid cells and dendritic cells in BRGSF-CBC mice induced by OKT3. Flt-3L-Ig (hum/hum) increases the release of *IL-2, CCL2* and CXCL10 in an OKT3-dependent manner. Flt-3L-Ig (hum/hum) can be used in studies related to cytokine release syndrome. Flt-3L-Ig (hum/hum) can be used in studies related to psoriasis-like skin inflammation ^[1] ^[2].

HY-P991426

MB-314	Transmembrane Glycoprotein IFNAR TNF Receptor	Cancer
MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0498

Bindarit Maximum Cited Publications 29 Publications Verification AF2838	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC. Endocrinology Source Classification Cancer	CCR
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23*. Bindarit also has anti-inflammatory activity ^[1].

HY-W007376

Indole-3-carboxaldehyde 3 Publications Verification 3-Formylindole	Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Cruciferae Other Diseases Isatis tinctoria L. Plants Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite
Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract ^[1] ^[2].

HY-33037

Phenazine-1-carboxylic acid	Infection Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Marine natural products Disease Research Fields Source Classification	Fungal
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation ^[1] ^[2] .

HY-N3007

Naringenin chalcone 5+ Cited Publications	Structural Classification Classification of Application Fields Plants Endogenous metabolite Human Gut Microbiota Metabolites Chalcones Flavonoids other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Drug Intermediate Apoptosis NO Synthase
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of *MCP-1* and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties ^[1] ^[2] .

HY-N0847

Micheliolide 5+ Cited Publications	Other Monoterpenes other families Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Source Classification	NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis ^[1] ^[2] .

HY-N9914

D-Psicose D-Allulose	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	p38 MAPK NF-κB
D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] ^[2] .

HY-N2572

Eupafolin Nepetin; 6-Methoxyluteolin	Structural Classification Classification of Application Fields Flavones Plants Compositae Flavonoids Lespedeza juncea (L. f.) Pers. Labiatae Cassia Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Interleukin Related
Eupafolin (Nepetin) (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Eupafolin inhibits IL-6, IL-8 and *MCP-1* secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells ^[1] ^[2].

HY-N0444

Rubiadin	Quinones Structural Classification Classification of Application Fields Anthraquinones Rubiaceae Phenols Polyphenols Plants Morinda officinalis How Inflammation/Immunology Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) NF-κB HBV Apoptosis Bacterial Fungal Parasite
Rubiadin is an orally active free radical scavenger that inhibits the activation of the NF-κB pathway. Rubiadin inhibits osteoclast formation, bone resorption, lipid peroxidation, HBV DNA replication and cancer cell proliferation; reduces pro-inflammatory cytokine levels; induces cancer cell apoptosis; and possesses antifungal, antimalarial, antibacterial and anticonvulsant activities. Rubiadin can be used in the research of osteoporosis, acute inflammation, chronic inflammation, carbon tetrachloride-induced liver injury, Alzheimer's disease, breast cancer, iron overload disorders, hepatitis B virus infection, colon cancer, liver cancer, T-lymphocytic leukemia, cervical cancer, diabetic nephropathy, epileptic seizures, fungal infections, malaria and bacterial infections ^[1] ^[2] .

HY-125740

Malvidin-3-glucoside chloride Malvidin-3-O-glucoside chloride; Oenin chloride	Classification of Application Fields Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids Sunscreen Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification	NF-κB TNF Receptor NO Synthase Interleukin Related
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as *MCP-1, ICAM-1, and IL-6*, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health ^[1] ^[2] .

HY-N1940

β-Anhydroicaritin 3 Publications Verification Cycloicaritin	Flavonols Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties ^[1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats ^[2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-W007376R

Indole-3-carboxaldehyde (Standard) 3-Formylindole (Standard)	Alkaloids Human Gut Microbiota Metabolites Microorganisms Cruciferae Isatis tinctoria L. Plants Endogenous metabolite Indole Alkaloids Source Classification	Reference Standards Endogenous Metabolite
Indole-3-carboxaldehyde (Standard) is the analytical standard of Indole-3-carboxaldehyde. This product is intended for research and analytical applications. Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract[1][2].

HY-N16129

Diplacone Nymphaeol A; Propolin C	Structural Classification Flavonoids Flavones Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants Source Classification	COX Reactive Oxygen Species (ROS) Calcium Channel Ferroptosis Mitochondrial Metabolism MMP
Diplacone is an orally active geranyl flavanone. It is isolated from the fruits of Paulownia tomentosa. Diplacone reduces *COX-2* levels and increases the *pro-MMP2/MMP2* ratio. It induces ferroptosis-mediated cell death. Diplacone enhances mitochondrial Ca ²⁺ influx and ROS production. It possesses anti-inflammatory and free radical-scavenging activities. Diplacone can be used in research related to ulcerative colitis and non-small cell lung cancer ^[1] ^[2] .

HY-N9914R

D-Psicose (Standard) D-Allulose (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards p38 MAPK NF-κB
D-Psicose (Standard) is the analytical standard of D-Psicose (HY-N9914). This product is intended for research and analytical applications. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] ^[2] .

HY-110151

Bengamide B	Structural Classification Alkaloids Other Alkaloids Marine natural products Sponge Source Classification	NF-κB Interleukin Related
Bengamide B is an alkaloid with anti-tumor and anti-inflammatory activities. Bengamide B reduces the phosphorylation level of IκBα, thereby blocking the activation of NF-κB. Bengamide B inhibits the proliferation of tumor cells. Bengamide B can be used in research related to inflammatory diseases and cancers ^[1] ^[2].

HY-125740R

Malvidin-3-glucoside chloride (Standard) Malvidin-3-O-glucoside chloride (Standard); Oenin chloride (Standard)	Structural Classification Anthocyans Flavonoids Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Source Classification	Reference Standards Interleukin Related NO Synthase NF-κB TNF Receptor
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride (Standard) is the analytical standard of Malvidin-3-glucoside chloride (HY-125740). This product is intended for research and analytical applications. Malvidin-3-glucoside chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as *MCP-1, ICAM-1, and IL-6*, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health ^[1] ^[2] .

HY-N3887

Evoxine Haplophytin B; Haplophytine B	Alkaloids Other Alkaloids Rutaceae Plants Haplophyllum acutifolium (DC.) G. Don Source Classification	Bacterial
Evoxine (Haplophytin B) is a compound that selectively inhibits CO2-induced immunosuppression and has activity in inhibiting the expression of interleukin-6 and chemokine CCL2 in human THP-1 macrophages. Evoxine shows antimicrobial activity against a wide range of bacteria, especially performing well in minimum inhibitory concentration (MIC) tests against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Evoxine extracts may find application in crude drug preparations in West Africa, provided that their in vivo toxicity results are negative ^[1].

HY-N3007R

Naringenin chalcone (Standard)	Structural Classification Human Gut Microbiota Metabolites Chalcones Flavonoids other families Phenols Polyphenols Plants Endogenous metabolite Source Classification	Reference Standards Drug Intermediate Apoptosis NO Synthase
Naringenin chalcone (Standard) is an analytical standard of Naringenin chalcone. This product is intended for research and analytical applications. Naringenin chalcone is an orally active intermediate in the biosynthesis of flavonols. Naringenin chalcone induces apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties.

HY-N0847R

Micheliolide (Standard)	Structural Classification Other Monoterpenes other families Terpenoids Plants Source Classification	Reference Standards NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis ^[1] ^[2] .

HY-N2572R

Eupafolin (Standard) Nepetin (Standard); 6-Methoxyluteolin (Standard)	Structural Classification Flavonoids Lespedeza juncea (L. f.) Pers. Flavones Labiatae Cassia Phenols Polyphenols Plants Compositae Source Classification	Reference Standards Interleukin Related
Eupafolin (Standard) is the analytical standard of Eupafolin. This product is intended for research and analytical applications. Eupafolin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Eupafolin inhibits IL-6, IL-8 and MCP-1 secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells ^[1] ^[2].

HY-33037R

Phenazine-1-carboxylic acid (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Marine natural products Source Classification	Reference Standards Fungal
Phenazine-1-carboxylic acid (Standard) is the analytical standard of Phenazine-1-carboxylic acid. This product is intended for research and analytical applications. Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4].

HY-N17908

Viscumneoside V	Structural Classification Flavonols Flavonoids Viscum angulatum B.Heyne ex DC. Plants Source Classification Santalaceae	CCR
Viscumneoside V is a plant-derived anti-inflammatory agent present in Viscum album var. coloratum. Viscumneoside V inhibits the expression of *MCP-1* and promotes the production of RANTES in LPS-stimulated immune cells. Viscumneoside V can be used for research related to skin rashes ^[1].

HY-N17779

3-O-Caffeoyl-5-O-feruloylquinic acid	Structural Classification Simple Phenylpropanols Alfredia cernua (L.) Cass. Phenylpropanoids Umbelliferae Plants Source Classification	TNF Receptor Reactive Oxygen Species (ROS)
3-O-Caffeoyl-5-O-feruloylquinic acid is a quinic acid-based phenolic compound that can be isolated from Eryngium bourgatii. 3-O-Caffeoyl-5-O-feruloylquinic acid regulates free radical scavenging and inflammatory pathways, exerting antioxidant activity through electron transfer and hydrogen atom transfer mechanisms. It also inhibits TNF-α-induced reactive oxygen species (ROS) production and the production of monocyte chemoattractant protein-1 (MCP-1) and its transcripts in human umbilical vein endothelial cells (HUVECs).

HY-N10175

Berkeleyacetal C	Other Terpenoids Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase NF-κB ERK Interleukin Related TNF Receptor Reactive Oxygen Species (ROS)
keleyacetal C, a meroterpenoid compound with anti-inflammatory effects via inhibiting NF-κB, *ERK1/2* and IRF3 signaling pathways. Berkeleyacetal C significantly inhibits the expression of iNOS and the following NO production by macrophages. Berkeleyacetal C inhibits expression and secretion of key pro-inflammatory factors and chemokines (TNF-α, IL-6, *IL-1β, MIP-1α, and MCP-1). Berkeleyacetal C also inhibits activation of neutrophils and reactive oxygen species (ROS)* production. Berkeleyacetal C can be used for the study of inflammatory disorders ^[1].

Species:	Human (7) Rat (1) Mouse (7) Cynomolgus (1) Pig (1)
Tag:	His (11) Tag Free (5) Avi (2) Myc (1) Fc (1)
Source:	HEK293 (9) Sf9 insect cells (2) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700034AF

	*Animal-Free MCP-1/CCL2* Protein, Human (His)** 3 Publications Verification C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	E. coli
	MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. Animal-Free MCP-1/CCL2 Protein, Human (His) is the recombinant human-derived animal-FreeMCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P700231AF

	*Animal-Free MCP-1/CCL2* Protein, Pig (His)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Pig	E. coli
	MCP-1/CCL2 protein acts as a ligand for CCR2, inducing chemotactic responses and calcium mobilization. It attracts monocytes and basophils but not neutrophils or eosinophils. Animal-Free MCP-1/CCL2 Protein, Pig (His) is the recombinant pig-derived animal-Free MCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag.This product is for cell culture use only.

HY-P700787

	MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Cynomolgus	HEK293
	MCP-1/CCL2 protein activates CCR2 and induces chemotaxis and calcium ion mobilization. It attracts monocytes and basophils, not neutrophils or eosinophils. It also contributes to neuropathic pain and enhances synaptic transmission in dopamine neurons. MCP-1/CCL2 exists as a monomer or homodimer and binds to endothelial cells through proteoglycans. It interacts with TNFAIP6 via its Link domain. MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MCP-1/CCL2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704401

	MCP-1/CCL2 Protein, Human (HEK293, hFc) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. MCP-1/CCL2 Protein, Human (HEK293, hFc) is the recombinant human-derived MCP-1/CCL2 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P78488

	MCP-1/CCL2 Protein, Human (HEK293, His-Avi) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P78173

	MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P7764

	MCP-1/CCL2 Protein, Mouse Maximum Cited Publications 9 Publications Verification rMuCCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; CCL2; Scya2	Mouse	E. coli
	MCP-1/CCL2 Protein, Mouse is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse is a mouse MCP-1/CCL2 (Q24-R96) expressed by E.coil.

HY-P700164AF

	*Animal-Free MCP-1/CCL2* Protein, Mouse (His)** Monocyte Chemotactic Protein-1; MCP-1; JE	Mouse	E. coli
	The MCP-1/CCL2 protein, as a CCR2 ligand, induces potent chemotactic responses and intracellular calcium mobilization in monocytes and basophils, without affecting neutrophils or eosinophils.It is critical for neuropathic pain and enhances NMDA-mediated synaptic transmission in neurons containing dopamine D1 and D2 receptors, possibly involving MAPK/ERK-dependent GRIN2B/NMDAR2B phosphorylation.Animal-Free MCP-1/CCL2 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMCP-1/CCL2 protein, expressed by E.coli , with N-His labeled tag.This product is for cell culture use only.

HY-P7237

	MCP-1/CCL2 Protein, Human Maximum Cited Publications 9 Publications Verification rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Human	E. coli
	MCP-1/CCL2 Protein, Human is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human is a recombinant human MCP-1/CCL2(Q24-T99) expressed by E.coil.

HY-P7235

	MCP-1/CCL2 Protein, Mouse (HEK293) rMuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293) is a mouse MCP-1/CCL2 (Q24-R96) expressed by HEK293.

HY-P74758

	MCP-1/CCL2 Protein, Mouse (sf9, His) C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (sf9, His) is a mouse MCP-1/CCL2 expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P7236

	MCP-1/CCL2 Protein, Rat (HEK293, C-His) 1 Publications Verification rRtMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Rat	HEK293
	MCP-1/CCL2 Protein, Rat (HEK293, His) is a small cytokine that belongs to the CC chemokine family.

HY-P76489

	MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a biotinylated mouse MCP-1/CCL2 (M1-N148) expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P700541

	CCR2 Protein, Mouse (N-His, C-Myc) 1 Publications Verification CCR2; chemokine (C-C motif) receptor 2; CMKBR2; CC CKR 2; CD192; CKR2; FLJ78302; MCP 1 R; CCR2A; CCR2B; CKR2A; CKR2B; MCP-1-R; CC-CKR-2	Mouse	E. coli
	CCR2 protein is an important chemokine receptor that coordinates chemotaxis and migration by binding to CCL2, CCL7, and CCL12 and activating the PI3K cascade. In addition to chemokine signaling, CCR2 regulates T cell inflammatory cytokines, promotes Th17 cell generation, and promotes mature thymocyte output. CCR2 Protein, Mouse (N-His, C-Myc) is the recombinant mouse-derived CCR2 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P72757

	MCP-1/CCL2 Protein, Mouse (HEK293, His) C-C motif chemokine ligand 2; GDCF-2; HC11; HSMCR30; MCAF; SCYA2; SMC-CF	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293, His) is a mouse MCP-1/CCL2 expressed by HEK293 with a His tag at the C-terminus.

HY-P77589

	CCR2b Protein-VLP, Human (HEK293) C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2	Human	HEK293
	CCR2b Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P77590

	CCR2b Protein-VLP, Human (Biotinylated, HEK293) C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2	Human	HEK293
	CCR2b Protein-VLP, Human (Biotinylated, HEK293) is recommended only for SPR analysis. HY-P77589 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

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Cat. No.	Product Name	Chemical Structure

HY-B0673S1

Deupirfenidone
Deupirfenidone-d₃ is the deuterium labeled Pirfenidone (HY-B0673). Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[1] ^[2] .

HY-B0673S

Pirfenidone-d5
Pirfenidone-d₅ (AMR69-d₅) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[1] ^[2] .

HY-B1203S

Fludrocortisone-d5

Fludrocortisone-d₅ (9α-Fludrocortisone-d₅) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.

HY-B1203S1

Fludrocortisone-d2

Fludrocortisone-d₂ (9α-Fludrocortisone-d₂) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.

HY-W753956

Iminostilbene-d10

Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases ^[1] ^[2].

HY-B1322AS1

Amodiaquine-d10 hydrochloride

Amodiaquine-d₁₀ hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect ^[1] ^[2] .

Host:	Mouse (4) Rabbit (6)
Reactivity:	Human (10) Rat (5) Mouse (5) Monkey (2)
Application:	IHC-P (6) ICC/IF (6) IF-Tissue (1) IP (3) IHC-F (2) WB (9) FC (7) ELISA (8)
Isotype:	IgG,Kappa (1) IgG (5) IgG1 (4)
Conjugation:	Non-conjugated (10) Biotin (3)
Clonality:	Polyclonal (3) Monoclonal (4) Monoclonal Antibody (1) Recombinant (3)
Modification:	Unmodified (8)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87858

	MCP-1 Antibody (YA7543)	WB, IHC-P, ICC/IF, IP, ELISA	Human
	MCP-1 Antibody (YA7543) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to MCP-1.

HY-P84082

	MCP1 Antibody (YA3779) HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	MCP1 Antibody (YA3779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCP1.

HY-P84082A

	MCP1 Antibody (YA3779)(PBS only) HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	MCP1 Antibody (YA3779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCP1.

HY-P81171

	MCP1 Antibody MCP-1/CCL2; C-C motif chemokine 2; CCL 2; CCL2; CCL2_HUMAN; Chemokine (C C motif) ligand 2; Chemokine C C motif ligand 2; Chemokine CC Motif Ligand 2; GDCF 2; GDCF 2 HC11; GDCF-2; GDCF2; HC11; HSMCR30; HSMCR30; JE; MCAF; MCP 1; MCP-1; MGC9434; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; SCYA2; Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig JE); Small inducible cytokine A2; Small inducible cytokine subfamily A (Cys Cys), member 2; Small inducible cytokine subfamily A Cys Cys member 2; Small-inducible cytokine A2; SMC CF; SMC-CF; SMCCF.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Rat
	MCP1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MCP1.

HY-P810954

	CCRL2 Antibody CCR11, CCR6, CKRX, CRAM, HCR, CCRL2, C-C chemokine receptor-like 2, Chemokine receptor CCR11, Chemokine receptor X, Putative MCP-1 chemokine receptor	WB, ICC/IF	Human, Mouse, Rat
	CCRL2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CCRL2.

HY-P810956

	TBX18 Antibody CCR11; CCR6; CKRX; CRAM; HCR; C-C chemokine receptor-like 2; Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor	WB, ICC/IF	Human, Mouse, Rat
	TBX18 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to TBX18.

HY-P87536

	CCR-2 Antibody (YA7220) CD192, Cmkbr2, Ccr2, C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2, JE/FIC receptor, MCP-1 receptor	IHC-P, IHC-F, IP, FC, IF-Tissue	Human
	CCR-2 Antibody (YA7220) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCR-2.

HY-P80385

	CCR2 Antibody (YA548) 1 Publications Verification C C chemokine receptor type 2 antibody; C C CKR 2 antibody; C-C chemokine receptor type 2 antibody; C-C CKR-2 antibody; CC chemokine receptor type 2 antibody; CC CKR 2 antibody; CC-CKR-2 antibody; CCCKR2 antibody; CCR 2 antibody; CCR-2 antibody; CCR1L antibody; CCR2 antibody; CCR2_HUMAN antibody; CCR2A antibody; CCR2B antibody; CCR5L antibody; CD192 antibody; CD192 antigen antibody; Chemokine C C motif receptor 2 antibody; Chemokine CC Motif Receptor 2 antibody; CKR 2 antibody; CKR2 antibody; CKR2A antibody; CKR2B antibody; CMKBR2 antibody; MCP 1 R antibody; MCP-1-R antibody; MCP1 RECEPTOR antibody; MCP1R antibody; Monocyte chemoattractant protein 1 receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody	WB, IHC-P, IP, FC	Human, Mouse
	CCR2 Antibody (YA548) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCR2.

HY-P84311

	CCR2 Antibody (YA4008) CCR2; CKR2; CCR-2; CCR2A; CCR2B; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2	WB, FC, ELISA	Human
	CCR2 Antibody (YA4008) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCR2.

HY-P84311A

	CCR2 Antibody (YA4008)(PBS only) CCR2; CKR2; CCR-2; CCR2A; CCR2B; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2	WB, FC, ELISA	Human
	CCR2 Antibody (YA4008) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCR2.

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Cat. No.	Product Name		Classification

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36		Aptamers
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice ^[1] ^[2] .

HY-160552

244cis		Cationic Lipids
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels ^[1].

HY-RS16514

Ccl2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ccl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-148100A

Emapticap pegol sodium 1 Publications Verification NOX-E36 sodium		Aptamers
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) ^[1] ^[2] .

HY-174763

*Human CCL2* mRNA**		mRNA Chemokine & Receptors
Human CCL2 mRNA encodes the human C-C motif chemokine ligand 2 (CCL2) protein. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis.

HY-RS02089

CCL2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22945

Ccl2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ccl2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174744

Human CCR4 mRNA		mRNA Chemokine & Receptors
Human CCR4 mRNA encodes the human C-C motif chemokine receptor 4 (CCR4) protein, a member of G protein-coupled receptors family. CCR4 is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

HY-177933

mNOX-E36		Aptamers
mNOX-E36 is a murine-specific analogue of NOX-E36 (HY-148100), an anti-CCL-2 L-RNA aptamer that binds and neutralises the mouse chemokine CCL-2. mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery (GFS). mNOX-E36 ameliorates lupus nephritis in mice. mNOX-E36 can be used for GFS and lupus nephritis research ^[1] ^[2].

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