2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. ST247

ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ.

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ST247 Chemical Structure

ST247 Chemical Structure

CAS No. : 1356497-91-0

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ST247 Related Antibodies

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ[1].

IC50 & Target

PPARβ/δ

 

In Vitro

ST247 induces a clearly enhanced interaction of the PPARβ/δ LBD with the SMRT-ID2 peptide, with an EC50 of 10 nM[1].
ST247 down-regulates basal level expression of the peroxisome proliferator responsive element-driven PPARβ/δ target gene ANGPTL4, with an IC50 of 19.1 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ST247 Related Antibodies
Molecular Weight

426.55

Formula

C19H26N2O5S2
CAS No.
SMILES

O=C(C1=C(S(=O)(NC2=CC=C(NCCCCCC)C=C2OC)=O)C=CS1)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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ST247 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST2471356497-91-0ST 247ST-247PPARPeroxisome proliferator-activated receptorsWPMY-1 cellsANGPTL4CCL2inverse agonistmetabolisminflammationInhibitorinhibitorinhibit

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