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Cat. No.: HY-10109A

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AS-605240 potassium

Name: AS-605240 potassium
Brand: MedChemExpress
SKU: HY-10109A
Availability: PreOrder

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC₅₀: 8 nM; K_i: 7.8 nM). AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC₅₀ values are 0.181 and 0.550 µM, respectively). AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5)- and thioglycolate-induced peritonitis mouse models (EC₅₀ values are 9.1 and 10 mg/kg, respectively). AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice.

For research use only. We do not sell to patients.

Formula: C₁₂H₆KN₃O₂S
Molecular Weight:295.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

AS-605240 potassium Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (4)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

PI3Kγ

8 nM (IC₅₀)

All PI3K Isoforms :

All Akt Isoforms :

Chemical Information

Molecular Weight 295.36
Formula C₁₂H₆KN₃O₂S
SMILES

O=C([N-]C/1=O)SC1=C/C2=CC3=C(N=CC=N3)C=C2.[K+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

All Cell Proliferation/Viability AssayCell Imaging/StainingRT-PCRWBHistological Imaging/Staining

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Cell Syst

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells. [Abstract]

2020 Jan 22;10(1):66-81.e11. PMID: 31812693
Drug Des Devel Ther

AS-605240 Blunts Osteoporosis by Inhibition of Bone Resorption. [Abstract]

2023 Apr 27:17:1275-1288. PMID: 37138583

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

The effect of AS-605240 (AS) on cell viability of BMMs by CCK-8 assay at 24, 48, 72, and 96 h.

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

BMMs were treated with RANKL (50 ng/mL) and M-CSF (30 ng/mL) in the presence of 0, 1.25, 2.5, and 5.0 μM AS-605240 (AS) for 6 days followed by TRAP staining.

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

The expression levels of osteoclast-associated genes were measured by RT-qPCR treated with AS-605240 (AS) (0, 1.25, 2.5, 5.0 μM).

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

BMMs were treated with or without AS-605240 (AS) (5μM) on days 1, 3, and 5, and the proteins of c-Fos and NFATc1 were detected by WB.

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

Representative graphs of H&E and TRAP staining of femoral sections from different groups of mice treated with AS-605240 (AS) (20 mg/kg,i.p.).
Molecules

In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei. [Abstract]

2020 Apr 23;25(8):1980. PMID: 32340370
J Neurochem

Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. [Abstract]

2022 Jun;161(6):478-491. PMID: 35583089

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Camps M, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11(9):936-43. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

AS-605240 potassium

4 Cited Publications

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (4)
Purity & Documentation
References

1/16
1/16

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

Customer Validation
The effect of AS-605240 (AS) on cell viability of BMMs by CCK-8 assay at 24, 48, 72, and 96 h.
1/16

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

Customer Validation
BMMs were treated with RANKL (50 ng/mL) and M-CSF (30 ng/mL) in the presence of 0, 1.25, 2.5, and 5.0 μM AS-605240 (AS) for 6 days followed by TRAP staining.
1/16

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

Customer Validation
The expression levels of osteoclast-associated genes were measured by RT-qPCR treated with AS-605240 (AS) (0, 1.25, 2.5, 5.0 μM).
1/16

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

Customer Validation
BMMs were treated with or without AS-605240 (AS) (5μM) on days 1, 3, and 5, and the proteins of c-Fos and NFATc1 were detected by WB.
1/16

AS-605240 potassium purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2023 Apr 27:17:1275-1288. [Abstract]

Customer Validation
Representative graphs of H&E and TRAP staining of femoral sections from different groups of mice treated with AS-605240 (AS) (20 mg/kg,i.p.).

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AS-605240 potassium

Publications Citing Use of MedChemExpress (MCE) AS-605240 potassium

All PI3K Isoforms

All Akt Isoforms