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Cat. No.: HY-10109A

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AS-605240 potassium

4 Cited Publications

고객리뷰

Based on 4 publication(s) in Google Scholar

AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC₅₀: 8 nM; K_i: 7.8 nM). AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC₅₀ values are 0.181 and 0.550 µM, respectively). AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5)- and thioglycolate-induced peritonitis mouse models (EC₅₀ values are 9.1 and 10 mg/kg, respectively). AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice.

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화학식: C₁₂H₆KN₃O₂S
분자량:295.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

AS-605240 potassium Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (4)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PI3Kγ

8 nM (IC₅₀)

All PI3K Isoforms :

All Akt Isoforms :

Chemical Information

분자량 295.36
화학식 C₁₂H₆KN₃O₂S
SMILES

O=C([N-]C/1=O)SC1=C/C2=CC3=C(N=CC=N3)C=C2.[K+]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Journal Impact Factor

Cell Syst

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells. [Abstract]

2020 Jan 22;10(1):66-81.e11. PMID: 31812693
Drug Des Devel Ther

AS-605240 Blunts Osteoporosis by Inhibition of Bone Resorption. [Abstract]

2023 Apr 27:17:1275-1288. PMID: 37138583
Molecules

In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei. [Abstract]

2020 Apr 23;25(8):1980. PMID: 32340370
J Neurochem

Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. [Abstract]

2022 Jun;161(6):478-491. PMID: 35583089

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Camps M, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11(9):936-43. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

AS-605240 potassium

4 Cited Publications

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (4)
순도&문서
References

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AS-605240 potassium

Publications Citing Use of MedChemExpress (MCE) AS-605240 potassium

All PI3K Isoforms

All Akt Isoforms

Biological Activity

Chemical Information

Publications (4)

순도&문서

References

Calculators

Help & FAQs

AS-605240 potassium Related Classifications

HY-10109A Related Classifications