Glutaminyl Cyclase Inhibitor 6
Glutaminyl Cyclase Inhibitor 6 (compound BI-43) is a secretory glutaminyl cyclase (sQC) and golgi-resident glutaminyl cyclase (gQC) inhibitor with IC50 values of 0.012 0.040 µM, respectively. Glutaminyl Cyclase Inhibitor 6 has the potential for the research of Parkinson’s disease.
For research use only. We do not sell to patients.
- Formula: C27H23N5O3
- Molecular Weight:465.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.012 µM (secretory glutaminyl cyclase (sQC)); 0.040 µM (golgi-resident glutaminyl cyclase (gQC))[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks, 19-20 g, male C57BL/6J mice (MPTP-induced PD mouse model)[1]
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Dosage:10, 25, 40 mg/kg
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Administration:I.p.; daily for 7 days
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Result:Ameliorated the locomotor deficits associated with MPTP, Greatly improved the decreased locomotor ability observed in MPTP group.
Chemical Information
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Molecular Weight 465.50
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Formula C27H23N5O3
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SMILES
O=C(/C1=C\C2=CC3=C(C=C2)NC=N3)NC4=C1C(OC5CCN(CC5)C(C6=CC=NC=C6)=O)=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glutaminyl Cyclase Inhibitor 6 Related Classifications
HY-163655 Related Classifications
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