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Cat. No.: HY-P84082A

MCP1 Antibody (YA3779)(PBS only)

Name: MCP1 Antibody (YA3779)(PBS only)
Brand: MedChemExpress
SKU: HY-P84082A
Availability: PreOrder

(Synonyms: HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30)

MCP1 Antibody (YA3779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCP1.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FCM	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-1:2000	1:200-1:1000	1:200-1:1000	1:200-1:400	1:10000

Description

MCP1 Antibody (YA3779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCP1.

Host Mouse
Species Reactivity
Human, Mouse, Rat, Monkey
Observed Molecular Weight

Observed band size: 11 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 11 kDa

Immunogen

Purified recombinant fragment of human CCL2 full(aa 1-99).

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

MCP1 acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis^[1]^[2]^[3]^[4]^[5]^[6]^[7].
Subcellular Localization

Secreted
Expression

Tissue_specificity:Expression (protein level) in seminal plasma, endometrial fluid, and follicular fluid (PubMed: 23765988) . Expression in monocytes (PubMed: 2513477) .

Induction:Up-regulated upon hypertonic conditions (PubMed:23233732) . In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712) . Up-regulated by coagulation factor Xa (F10) in PAR-1 (F2R) -dependent manner in cardiac fibroblasts and endothelial cells (PubMed:30568593, PubMed:34831181) . Up-regulated by thrombin (F2) in endothelial cells (PubMed:30568593)
Subunit

Monomer or homodimer; in equilibrium (PubMed:15033992, PubMed:8898111, PubMed:8989326, PubMed:9837883). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (PubMed:9792674). Interacts with TNFAIP6 (via Link domain)
SwissProt ID

P13500
Gene ID

6347 [NCBI]
Synonyms

HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30