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NS-3-008 hydrochloride 

Cat. No.: HY-120897
Handling Instructions

NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease.

For research use only. We do not sell to patients.

NS-3-008 hydrochloride Chemical Structure

NS-3-008 hydrochloride Chemical Structure

CAS No. : 1172854-54-4

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Description

NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease[1].

IC50 & Target

IC50: 2.25 μM (G0s2)[1]

In Vitro

NS-3-008 binds to Hsd17b4; knockdown of Hsd17b4 decreased G0s2 mRNA levels, whereas overexpression of Hsd17b4 induced G0s2 mRNA expression. The inhibitory effects of NS-3-008 are blocked by knockdown of Hsd17b4 or deletion of the Stat5 binding site in the G0s2 promoter. NS-3-008 decreases the nuclear phosphorylation of Stat5[1].

In Vivo

NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. The phosphorylation of Stat5 and p65 protein is decreased, and SUN concentrations and renal caspase 3/7 activity decreased in 5/6Nx mice treated with NS-03-08. The F4/80-positive area and F4/80 protein levels are decreased in 5/6Nx mice treated with NS-3-008[1].

Molecular Weight

269.81

Formula

C₁₄H₂₄ClN₃

CAS No.

1172854-54-4

SMILES

N=C(NCC1=CC=CC=C1)NCCCCCC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NS-3-008OthersG0s2Ccl2transcriptionalStat5p65Hsd17b4CKDamelioraterenaldysfunctionInhibitorinhibitorinhibit

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NS-3-008 hydrochloride
Cat. No.:
HY-120897
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