Search Result

Results for "

LPS-induced NO production

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NO Synthase (36) 11β-HSD (1) ADC Payload (1) Adenosine Receptor (1) Akt (3) AMPK (2) Amyloid-β (1) Apoptosis (9) Autophagy (1) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (1) Cathepsin (2) Cholinesterase (ChE) (1) COX (11) Dengue Virus (1) Drug Derivative (9) DYRK (1) EGFR (2) Elastase (1) Endogenous Metabolite (3) Environmental Pollutants (3) Epigenetic Reader Domain (1) ERK (7) FAK (2) Flavivirus (1) FXR (1) Glucocorticoid Receptor (4) GSK-3 (2) HCV (1) HCV Protease (1) HDAC (2) Heme Oxygenase (HO) (1) Histone Demethylase (4) HSP (2) IKK (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (22) IRAK (7) Isotope-Labeled Compounds (1) JAK (2) JNK (4) Keap1-Nrf2 (3) Lipoxygenase (2) Melanocortin Receptor (1) mTOR (1) MyD88 (3) nAChR (2) Necroptosis (1) NF-κB (23) p38 MAPK (14) Parasite (4) PERK (1) PGE synthase (2) Phosphatase (1) PI3K (4) PPAR (1) PROTACs (1) Pyruvate Kinase (1) Reactive Oxygen Species (ROS) (12) Reference Standards (4) SOD (1) STAT (6) STING (1) TGF-β Receptor (4) TNF Receptor (26) Toll-like Receptor (TLR) (8) Topoisomerase (2) TREM receptor (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (10) Endocrinology (1) Infection (7) Inflammation/Immunology (95) Metabolic Disease (8) Neurological Disease (26)

By Targets:

NO Synthase (36)

11β-HSD (1)

ADC Payload (1)

Adenosine Receptor (1)

Akt (3)

AMPK (2)

Amyloid-β (1)

Apoptosis (9)

Autophagy (1)

Bacterial (2)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Caspase (1)

Cathepsin (2)

Cholinesterase (ChE) (1)

COX (11)

Dengue Virus (1)

Drug Derivative (9)

DYRK (1)

EGFR (2)

Elastase (1)

Endogenous Metabolite (3)

Environmental Pollutants (3)

Epigenetic Reader Domain (1)

ERK (7)

FAK (2)

Flavivirus (1)

FXR (1)

Glucocorticoid Receptor (4)

GSK-3 (2)

HCV (1)

HCV Protease (1)

HDAC (2)

Heme Oxygenase (HO) (1)

Histone Demethylase (4)

HSP (2)

IKK (3)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Interleukin Related (22)

IRAK (7)

Isotope-Labeled Compounds (1)

JAK (2)

JNK (4)

Keap1-Nrf2 (3)

Lipoxygenase (2)

Melanocortin Receptor (1)

mTOR (1)

MyD88 (3)

nAChR (2)

Necroptosis (1)

NF-κB (23)

p38 MAPK (14)

Parasite (4)

PERK (1)

PGE synthase (2)

Phosphatase (1)

PI3K (4)

PPAR (1)

PROTACs (1)

Pyruvate Kinase (1)

Reactive Oxygen Species (ROS) (12)

Reference Standards (4)

SOD (1)

STAT (6)

STING (1)

TGF-β Receptor (4)

TNF Receptor (26)

Toll-like Receptor (TLR) (8)

Topoisomerase (2)

TREM receptor (1)

Xanthine Oxidase (1)

By Research Areas:

Cancer (26)

Cardiovascular Disease (10)

Endocrinology (1)

Infection (7)

Inflammation/Immunology (95)

Metabolic Disease (8)

Neurological Disease (26)

128

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: WNK Kinase NO Synthase

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-15648F

GSK-J4 hydrochloride Maximum Cited Publications 55 Publications Verification	Histone Demethylase	Cancer
GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 .

HY-106950

Fosfructose Diphosphofructose; Esafosfan; FDP	Toll-like Receptor (TLR) COX	Cardiovascular Disease Neurological Disease Metabolic Disease
Fosfructose is an orally active cyclooxygenase-2 inhibitor and Toll-like receptor 4 modulator. Fosfructose reduces the expression of cyclooxygenase-2, thereby decreasing prostaglandin production. By inhibiting the Toll-like receptor 4 signaling pathway, Fosfructose downregulates LPS-induced adhesion molecule expression. Fosfructose is applicable to research related to ischemic stroke, epilepsy, sepsis, myocardial injury, osteoporosis, and ultraviolet B-induced skin damage .

HY-N0498

Nitidine chloride 4 Publications Verification	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Inflammation/Immunology Cancer
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N5060

Estragole 4-Allylanisole	Environmental Pollutants Parasite Apoptosis Keap1-Nrf2 NF-κB	Infection Neurological Disease Inflammation/Immunology
Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular ROS production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity .

HY-W047187

Lavandoside	Xanthine Oxidase NO Synthase TNF Receptor	Others
Lavandoside is an ABTS ^?+ free radical scavenger and a moderate inhibitor of xanthine oxidase (XO), with an IC₅₀ of 71.6 μM for inhibiting NO production in LPS-induced macrophages. Lavandoside exerts its antioxidant and potential anti-inflammatory effects by directly scavenging free radicals and inhibiting XO activity, a mechanism related to the hydroxyl groups in its molecular structure. Lavandoside can be isolated from lavender and can be used in the development of natural antioxidants and in research on oxidative stress-related diseases and inflammation-related diseases .

HY-20070

BMS-566394	TNF Receptor	Inflammation/Immunology
BMS-566394 is a selective, orally active TACE (ADAM17) inhibitor. BMS-566394 inhibits LPS-induced TNF-α production in whole blood. BMS-566394 selectively inhibits TACE activity .

HY-N0896

Inulicin 1 Publications Verification 1-O-Acetylbritannilactone	NF-κB COX	Inflammation/Immunology Cancer
Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK. Inulicin (1-O-Acetylbritannilactone) inhibits LPS-induced PGE₂ production and COX-2 expression, and NF-κB activation and translocation.

HY-148591

GSK761	Epigenetic Reader Domain	Inflammation/Immunology
GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC₅₀ value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of CD206 ⁺ regulatory macrophages by inhibiting SP140 .

HY-B1817

Zinc acetate	Environmental Pollutants Apoptosis Biochemical Assay Reagents HSP	Cardiovascular Disease Inflammation/Immunology Cancer
Zinc acetate acts as an immune response modulator. Zinc acetate enhances the expression of HSP-70 mRNA. Zinc acetate restores the proliferation and cytokine production capacities of splenocytes. Zinc acetate reduces the Apoptosis level of splenocytes in endotoxemic mice. Zinc acetate increases plasma zinc levels and improves survival rates in mice with LPS-induced lethal endotoxemia. Zinc acetate induces rapid death of prostate cancer cell lines in vitro. Zinc acetate inhibits the growth of prostate cancer xenografts in SCID mice. Zinc acetate can be used in endotoxemia research .

HY-124151

Adenosine-2'-monophosphate 2'-AMP; AdeNOsine 2'-phosphate; AMP 2'-phosphate	Adenosine Receptor Endogenous Metabolite	Neurological Disease
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A_2A receptor activation .

HY-N2008

Luteolin 5-O-glucoside	NO Synthase Reactive Oxygen Species (ROS)	Inflammation/Immunology
Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced ROS generation. Luteolin 5-O-glucoside suppresses the expression of iNOS and COX-2 in macrophages .

HY-118828B

12-Oxo phytodienoic acid (≥90%) 1 Publications Verification 12-OPDA (≥90%)	NF-κB p38 MAPK TNF Receptor Interleukin Related NO Synthase Keap1-Nrf2	Neurological Disease Inflammation/Immunology
12-Oxo phytodienoic acid (≥90%) (12-OPDA (≥90%)) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid (≥90%) induces the expression of SOCS-1 and inhibits LPS (HY-D1056)-induced activation of the NF-κB and p38 MAPK signaling pathways. 12-Oxo phytodienoic acid (≥90%) inhibits LPS-induced expression of IL-6 and TNF-α, and reduces LPS-induced NO production by decreasing iNOS levels. 12-Oxo phytodienoic acid (≥90%) induces activation of the Nrf2 signaling cascade. 12-Oxo phytodienoic acid (≥90%) can be used for the research of neurodegenerative diseases .

HY-N11011

Withaphysalin A	NF-κB STAT PERK JNK p38 MAPK PGE synthase Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Withaphysalin A is a withanolide compound with anti-inflammatory and antioxidant activities. Withaphysalin A inhibits LPS (HY-D1056)-induced nuclear translocation of NF-κB p65, as well as phosphorylation of STAT3, ERK, JNK and p38 MAPK. Withaphysalin A upregulates the expression of HO-1. Withaphysalin A inhibits LPS-induced production of NO, PGE₂, IL-1β, IL-6 and TNF-α. Withaphysalin A downregulates LPS-induced expression of iNOS and COX-2. Withaphysalin A interacts with B-cell activating factor protein (BAFF) to exert inhibitory effects. Withaphysalin A exhibits ELOVL6 inhibitory activity. Withaphysalin A can be used in the research of inflammatory diseases, nephrotic syndrome and chronic myeloid leukemia .

HY-N8371

Shizukaol B	NO Synthase COX Interleukin Related TNF Receptor	Inflammation/Immunology
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .

HY-147972

NF-κB/MAPK-IN-1	NF-κB p38 MAPK NO Synthase COX	Inflammation/Immunology
NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC₅₀ of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research .

HY-18862

PF-03715455	p38 MAPK	Inflammation/Immunology
PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC₅₀ values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC₅₀=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease) .

HY-W014223

2,4′-Dihydroxybenzophenone Ultraviolet absorber UV-0	Environmental Pollutants Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) MyD88 IRAK	Inflammation/Immunology
2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber .

HY-112456

IKK2-IN-4	IKK	Inflammation/Immunology
IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC₅₀ of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs .

HY-126390

(E/Z)-BCI 1 Publications Verification NSC 150117	Phosphatase Apoptosis	Inflammation/Immunology Cancer
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway .

HY-145564

Emprumapimod PF-07265803	p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Emprumapimod (PF-07265803) is a potent, orally active and selective inhibitor of p38α MAPK directly inhibits LPS-induced IL-6 production from RPMI-8226 cell (IC₅₀=100 pM). Emprumapimod can be used for the research of dilated cardiomyopathy and acute inflammatory pain .

HY-N3364

Lucidone	Flavivirus Dengue Virus TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK	Infection Inflammation/Immunology
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE₂ production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC₅₀=25 μM) .

HY-123789

T5342126 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC₅₀=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC₅₀s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

HY-176402

Dyrk1A-IN-13	DYRK NO Synthase	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Dyrk1A-IN-13 (Compound 1) is a DYRK1A inhibitor (IC₅₀: 41 nM). Dyrk1A-IN-13 reduces LPS-induced NO production and has antioxidant and anti-inflammatory activities. Dyrk1A-IN-13 can be used in the research of Alzheimer's disease, cancer and diabetes .

HY-155850

CIAC001	Pyruvate Kinase	Neurological Disease
CIAC001 is a Pyruvate Kinase PKM2 inhibitor with anti-neuroinflammatory activity. CIAC001 inhibits LPS-induced proinflammatory nitric oxide (NO) production and protects immunologically active BV-2 cells (IC₅₀=2.5 μM). CIAC001 also has anti-neuroinflammation in mouse models and inhibits chronic morphine-induced addiction .

HY-153673

PROTAC IRAK4 degrader-8	IRAK PROTACs	Cancer
PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC₅₀: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC₅₀: 1.8 nM)。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC₅₀s of 246 nM and 2.2 nM respectively .

HY-101041

(E)-AG 556 (E)-Tyrphostin AG 556	EGFR	Inflammation/Immunology
(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production .

HY-N8631

O-Acetylschisantherin L Acetylschisantherin L	NO Synthase	Inflammation/Immunology
O-Acetylschisantherin L (Acetylschisantherin L) is a natural lignan, which exhibits inhibitory effects on LPS-induced NO production in BV-2 cells with an IC₅₀ of 23.1 μM .

HY-N7697C

Chitohexaose hexahydrochloride	Toll-like Receptor (TLR) Interleukin Related Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Chitohexaose hexahydrochloride is a small molecular polysaccharide. Chitohexaose hexahydrochloride inhibits the binding of AgW to TLR4. Chitohexaose hexahydrochloride upregulates IL-10, inhibits LPS-induced upregulation of ROS, induces alternative activation of macrophages/monocytes, and suppresses LPS-induced production of TNF-α, IL-1β and IL-6. Chitohexaose hexahydrochloride reverses the mortality of mice challenged with APAP or LPS. Chitohexaose hexahydrochloride can be used in research related to Acetaminophen (HY-66005)-induced hepatotoxicity and endotoxemia .

HY-118160

PPM-18 NSC 73233	NO Synthase Drug Derivative IKK NF-κB HDAC Reactive Oxygen Species (ROS) AMPK mTOR PI3K Akt Autophagy Apoptosis	Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
PPM-18 (NSC 73233) is a Vitamin K (HY-B2172) analog. PPM-18 prevents LPS-induced IκBα degradation, thereby inhibiting NF-κB activation and nuclear translocation of NF-κB. PPM-18 inhibits LPS-induced nitrite production and iNOS expression. PPM-18 inhibits HDAC6. PPM-18 induces ROS accumulation, activates AMPK, inhibits the mTORC1 and PI3K/AKT pathways, initiates Autophagy, and induces Apoptosis. PPM-18 suppresses seizures in zebrafish and mouse epilepsy models. PPM-18 prevents LPS-induced lethal toxicity and delayed hypotension. PPM-18 exhibits anticancer activity against leukemia and bladder cancer. PPM-18 can be used in research related to septic shock, bladder cancer and atherosclerosis .

HY-18759

BMS-751324	p38 MAPK TNF Receptor	Inflammation/Immunology
BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA). BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model .

HY-N13184

Giraldoid B	TNF Receptor	Inflammation/Immunology
Giraldoid B is an active ingredient that can be isolated from Girald Daphne Bark. Giraldoid B can inhibit LPS induced NO and b>TNF-α production in RAW264.7 and has anti-inflammatory activity .

HY-N3392

Lethedoside A	NO Synthase	Inflammation/Immunology
Lethedoside A is a natural flavonoid that shows inhibitory activity for LPS-induced NO production in RAW 264.7 cells .

HY-N1317

Salirepin	Others	Neurological Disease
Salirepin is a phenolic glycoside from fruits of Idesia polycarpa, inhibits LPS-induced nitric oxide production .

HY-N8427

Bisacurone	NO Synthase	Inflammation/Immunology
Bisacurone is a natural terpenoid, exhibits inhibitory activities on LPS-induced NO production with an IC₅₀ of 29.8 μM .

HY-N12042

Taxamairin B	TNF Receptor PI3K Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice .

HY-P10159

DJK-5	Bacterial	Infection
Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .

HY-N12693

Isobiflorin	Others	Inflammation/Immunology
Isobiflorin is an anti-inflammatory agent and can be isolated from Syzygium aromaticum. Isobiflorin inhibits LPS-induced PGE2 production with an IC₅₀ value of 46.0 μM .

HY-N8104

15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid	Others	Inflammation/Immunology
15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid, a Lanostane triterpenoid, possesses NO production inhibitory activities of LPS-induced microglia .

HY-N12283

NF-κB-IN-13	NF-κB	Inflammation/Immunology
NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .

HY-120299

KC01	TNF Receptor	Inflammation/Immunology
KC01 is an effective inhibitor of ABHD16A, with IC₅₀s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages .

HY-N9866

Grasshopper ketone	Others	Inflammation/Immunology
It is a bioactive compound with anti-inflammatory activity that inhibits LPS-induced NO production in RAW 264.7 cells and acts by inhibiting the phosphorylation of MAPK (ERK, JNK and p38) and NF-κB p65. Grasshopper ketone, as an ingredient, has shown its potential in anti-inflammatory inhibition .

HY-120041

ND-2158	IRAK	Cancer
ND-2158 is a competitive IRAK4 inhibitor, with the K_i of 1.3 nM. ND-2158 suppresses LPS-induced TNF production in human white blood cells, alleviated collagen-induced arthritis, and blocked gout formation in mouse models. ND-2158 has antitumor activity in vivo .

HY-151921

Anti-inflammatory agent 33	p38 MAPK	Inflammation/Immunology
Anti-inflammatory agent 33 is a potent p38α inhibitor. Anti-inflammatory agent 33 inhibits NO production. Anti-inflammatory agent 33 inhibits LPS-induced iNOS, COX-2, p-p38α, p-MK2 protein expression. Anti-inflammatory agent 33 shows anti-inflammatory activity .

HY-150733

IRAK4-IN-19	IRAK	Inflammation/Immunology
IRAK4-IN-19 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 4.3 nM. IRAK4-IN-19 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-19 can be used for researching arthritis disease .

HY-172977

FGA139	Cathepsin NO Synthase TNF Receptor	Neurological Disease Inflammation/Immunology
FGA139 is a cysteine proteases inhibitor with IC₅₀ values of 4.98/3.14 μM for cathepsin B/L. FGA139 reduces LPS-induced NO production in RAW264.7 cells and tumor necrosis factor (TNFα) levels in microglia, and has anti-oxidative stress and anti-inflammatory activities. FGA139 promotes the secretion of neuroprotective metabolites purine and linoleic acid by LPS-stimulated microglia. FGA139 can be used in neuroinflammatory diseases research .

HY-117622

ND-2110	IRAK	Inflammation/Immunology Cancer
ND-2110 is a selective IRAK4 inhibitor (K_i: 7.5 nM). ND-2110 binds to the ATP pocket of IRAK4. ND-2110 targets the subset of activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL) cell lines with MYD88 L265P mutations,. ND-2110 inhibits LPS-induced TNF production, alleviates collagen-induced arthritis, and blocks gout formation in mouse models .

HY-P11250

HVF18-a3-d	Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK	Infection Inflammation/Immunology
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects .

HY-N1330

Rubranol	NO Synthase	Inflammation/Immunology
Rubranol is an inhibitor of NO Synthase. Rubranol inhibits LPS-induced NO production in activated macrophages with 74% inhibition .

HY-N2053

Physalin L	NO Synthase Endogenous Metabolite	Inflammation/Immunology
Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity .

HY-117601

11-Deoxyalisol B	FXR NO Synthase	Inflammation/Immunology
11-Deoxyalisol B, a triterpene, shows the potent inhibitory activity on Lipopolysaccharide (LPS)-induced nitric oxide (NO) production .

Cat. No.	상품명	Target	Research Area

HY-P10159

DJK-5	Bacterial	Infection
Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .

HY-P11250

HVF18-a3-d	Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK	Infection Inflammation/Immunology
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-P11736

mcIRBP-9	NF-κB	Metabolic Disease
mcIRBP-9 is an orally active NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N0305

5-Aminolevulinic acid hydrochloride Maximum Cited Publications 20 Publications Verification 5-ALA hydrochloride; δ-AmiNOlevulinic acid hydrochloride; 5-AmiNO-4-oxopentaNOic acid hydrochloride	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer	Reactive Oxygen Species (ROS)
5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) hydrochloride is an orally active heme precursor. 5-Aminolevulinic acid hydrochloride promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid hydrochloride enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid hydrochloride selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid hydrochloride can be applied to the research of septic shock, melanoma, and cancer radiotherapy .

HY-W000450

5-Aminolevulinic acid Maximum Cited Publications 20 Publications Verification 5-ALA; δ-AmiNOlevulinic acid; 5-AmiNO-4-oxopentaNOic acid	Cardiovascular Disease Structural Classification Classification of Application Fields Amino acids Endogenous metabolite Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS)
5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) is an orally active heme precursor. 5-Aminolevulinic acid promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid can be applied to the research of septic shock, melanoma, and cancer radiotherapy .

HY-106950

Fosfructose Diphosphofructose; Esafosfan; FDP	Cardiovascular Disease Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Toll-like Receptor (TLR) COX
Fosfructose is an orally active cyclooxygenase-2 inhibitor and Toll-like receptor 4 modulator. Fosfructose reduces the expression of cyclooxygenase-2, thereby decreasing prostaglandin production. By inhibiting the Toll-like receptor 4 signaling pathway, Fosfructose downregulates LPS-induced adhesion molecule expression. Fosfructose is applicable to research related to ischemic stroke, epilepsy, sepsis, myocardial injury, osteoporosis, and ultraviolet B-induced skin damage .

HY-N0498

Nitidine chloride 4 Publications Verification	Alkaloids Classification of Application Fields Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N5060

Estragole 4-Allylanisole	Structural Classification Pandanus amaryllifolius Roxb. Simple Phenylpropanols Phenylpropanoids Plants Pandanaceae Source Classification	Environmental Pollutants Parasite Apoptosis Keap1-Nrf2 NF-κB
Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular ROS production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity .

HY-124529

Lunularin	Structural Classification Human Gut Microbiota Metabolites other families Conocephalum conicum (L.) Dumort. Phenols Polyphenols Plants Endogenous metabolite Source Classification	11β-HSD Endogenous Metabolite
Lunularin is an inhibitor of 11β-hydroxysteroid dehydrogenase 1, with an IC₅₀ of 45.44 μM and a K_i of 35.8 μM against human 11β-HSD1, and an IC₅₀ of 17.39 μM and a K_i of 10.31 μM against rat 11β-HSD1. Lunularin upregulates the transcription levels of Sirt1 and Hmox1 genes in the liver. Lunularin reduces food intake and body weight gain, and decreases blood glucose levels in mice fed a high-fat diet. Lunularin inhibits LPS-induced TLR4-mediated NF-κB pathway activation and nitric oxide production. Lunularin inhibits the proliferation and colony formation of renal cancer and colon cancer cells, and exhibits cancer cell-specific cytotoxicity. Lunularin binds to the steroid-binding site of human 11β-HSD1 and the steroid/NADPH-binding region of rat 11β-HSD1, but does not inhibit 11β-HSD2 or mouse 11β-HSD1. Lunularin can be used in research related to diet-induced obesity, renal cancer, colorectal cancer, inflammatory diseases and metabolic syndrome .

HY-W047187

Lavandoside	Structural Classification other families Onychium japonicum (Thunb.) Kunze Ketones, Aldehydes, Acids Plants	Xanthine Oxidase NO Synthase TNF Receptor
Lavandoside is an ABTS ^?+ free radical scavenger and a moderate inhibitor of xanthine oxidase (XO), with an IC₅₀ of 71.6 μM for inhibiting NO production in LPS-induced macrophages. Lavandoside exerts its antioxidant and potential anti-inflammatory effects by directly scavenging free radicals and inhibiting XO activity, a mechanism related to the hydroxyl groups in its molecular structure. Lavandoside can be isolated from lavender and can be used in the development of natural antioxidants and in research on oxidative stress-related diseases and inflammation-related diseases .

HY-N12586

Pheophytin a	Suaeda vermiculata Forssk. ex J.F.Gmel. Structural Classification Alkaloids Other Alkaloids Amaranthaceae Plants Source Classification	ERK Reactive Oxygen Species (ROS) COX PGE synthase STAT HCV HCV Protease
Pheophytin a is a multi-target inhibitor, anticancer agent, antioxidant and antiviral agent. Pheophytin a directly binds to and inhibits HCV-NS3/4A protease (IC₅₀=0.89 μM) to block viral replication. Pheophytin a also scavenges free radicals, reduces ferric ions, and exhibits cytotoxic activity against breast cancer cells. Pheophytin a effectively inhibits *LPS*-induced production of nitric oxide, prostaglandin E2, NOS2 and COX-2, as well as various pro-inflammatory cytokines, by downregulating the transcription levels of inflammatory mediators and blocking the ERK1/2 and STAT-1 pathways. In a low nerve growth factor environment, Pheophytin a also enhances ERK1/2 phosphorylation and synergistically promotes neurite outgrowth through MAPK pathway. Pheophytin a can be used to investigate the pathogenic mechanisms of diseases including chronic hepatitis C, sepsis, breast cancer and Alzheimer's disease .

HY-N0896

Inulicin 1 Publications Verification 1-O-Acetylbritannilactone	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	NF-κB COX
Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK. Inulicin (1-O-Acetylbritannilactone) inhibits LPS-induced PGE₂ production and COX-2 expression, and NF-κB activation and translocation.

HY-124151

Adenosine-2'-monophosphate 2'-AMP; AdeNOsine 2'-phosphate; AMP 2'-phosphate	Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Adenosine Receptor Endogenous Metabolite
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A_2A receptor activation .

HY-N13250

Hawthorn Extract	Cardiovascular Disease Classification of Application Fields Rosaceae Plants Disease Research Fields Source Classification	Apoptosis AMPK Elastase Bcl-2 Family Interleukin Related Caspase PI3K Akt SOD
Hawthorn Extract is an orally active hawthorn extract. Hawthorn Extract decreases Bax expression and increases Bcl-2 expression in the aorta. Hawthorn Extract regulates the AMPK signaling pathway, induces apoptosis, enhances the hepatic antioxidant system, and ameliorates symptoms of liver injury, inflammation and cancer. Hawthorn Extract reduces plasma levels of pro-inflammatory factors, increases plasma levels of anti-inflammatory adiponectin, and alleviates atherosclerotic plaque lesions in the aorta. Hawthorn Extract improves symptoms associated with chronic heart failure . Hawthorn Extract inhibits FMLP-induced superoxide anion production, Elastase release, ILB₄ generation and calcium signaling in neutrophils, and also reduces LPS-induced cytokine production in neutrophils. Hawthorn Extract induces autophagy and inhibits the proliferation of intestinal stem cells. Hawthorn Extract can be used in research related to atherosclerosis, hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, hepatocellular carcinoma, chronic heart failure and hypotension .

HY-N2008

Luteolin 5-O-glucoside	Flavonoids Classification of Application Fields Flavones Vigna angularis (Willd.) Ohwi et Ohashi Plants Compositae Inflammation/Immunology Disease Research Fields	NO Synthase Reactive Oxygen Species (ROS)
Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced ROS generation. Luteolin 5-O-glucoside suppresses the expression of iNOS and COX-2 in macrophages .

HY-N11011

Withaphysalin A	Structural Classification Physalis minima Linn. Solanaceae Plants Steroids Source Classification	NF-κB STAT PERK JNK p38 MAPK PGE synthase Interleukin Related TNF Receptor COX
Withaphysalin A is a withanolide compound with anti-inflammatory and antioxidant activities. Withaphysalin A inhibits LPS (HY-D1056)-induced nuclear translocation of NF-κB p65, as well as phosphorylation of STAT3, ERK, JNK and p38 MAPK. Withaphysalin A upregulates the expression of HO-1. Withaphysalin A inhibits LPS-induced production of NO, PGE₂, IL-1β, IL-6 and TNF-α. Withaphysalin A downregulates LPS-induced expression of iNOS and COX-2. Withaphysalin A interacts with B-cell activating factor protein (BAFF) to exert inhibitory effects. Withaphysalin A exhibits ELOVL6 inhibitory activity. Withaphysalin A can be used in the research of inflammatory diseases, nephrotic syndrome and chronic myeloid leukemia .

HY-N8371

Shizukaol B	Terpenoids Sesquiterpenes Chloranthaceae Plants Source Classification Chloranthus henryi Hemsl.	NO Synthase COX Interleukin Related TNF Receptor
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .

HY-N3364

Lucidone	Natural Products Lindera lucida (Blume) Boerl. Plants Lauraceae Source Classification	Flavivirus Dengue Virus TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE₂ production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC₅₀=25 μM) .

HY-N8631

O-Acetylschisantherin L Acetylschisantherin L	Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae Source Classification	NO Synthase
O-Acetylschisantherin L (Acetylschisantherin L) is a natural lignan, which exhibits inhibitory effects on LPS-induced NO production in BV-2 cells with an IC₅₀ of 23.1 μM .

HY-N7697C

Chitohexaose hexahydrochloride	Structural Classification Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Source Classification	Toll-like Receptor (TLR) Interleukin Related Reactive Oxygen Species (ROS)
Chitohexaose hexahydrochloride is a small molecular polysaccharide. Chitohexaose hexahydrochloride inhibits the binding of AgW to TLR4. Chitohexaose hexahydrochloride upregulates IL-10, inhibits LPS-induced upregulation of ROS, induces alternative activation of macrophages/monocytes, and suppresses LPS-induced production of TNF-α, IL-1β and IL-6. Chitohexaose hexahydrochloride reverses the mortality of mice challenged with APAP or LPS. Chitohexaose hexahydrochloride can be used in research related to Acetaminophen (HY-66005)-induced hepatotoxicity and endotoxemia .

HY-N13184

Giraldoid B	Thymelaeaceae Daphne giraldii Nitsche Coumarins Phenylpropanoids Plants Source Classification	TNF Receptor
Giraldoid B is an active ingredient that can be isolated from Girald Daphne Bark. Giraldoid B can inhibit LPS induced NO and b>TNF-α production in RAW264.7 and has anti-inflammatory activity .

HY-N9164

Hecubine	Apocynaceae Structural Classification Alkaloids Piperidine Alkaloids Tabernaemontana bufalina Lour. Plants Source Classification	TREM receptor Toll-like Receptor (TLR) MyD88 NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TNF Receptor Interleukin Related p38 MAPK PI3K Akt Reactive Oxygen Species (ROS)
Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases .

HY-N3392

Lethedoside A	Flavonoids Flavones Thymelaeaceae Plants Aquilaria sinensis (Lour.) Spreng. Source Classification	NO Synthase
Lethedoside A is a natural flavonoid that shows inhibitory activity for LPS-induced NO production in RAW 264.7 cells .

HY-N1317

Salirepin	Monophenols Melia azedarach L. Phenols Plants Meliaceae Source Classification	Others
Salirepin is a phenolic glycoside from fruits of Idesia polycarpa, inhibits LPS-induced nitric oxide production .

HY-N8427

Bisacurone	Terpenoids Sesquiterpenes Plants Curcuma longa Source Classification Zingiberaceae	NO Synthase
Bisacurone is a natural terpenoid, exhibits inhibitory activities on LPS-induced NO production with an IC₅₀ of 29.8 μM .

HY-N12042

Taxamairin B	Terpenoids Taxaceae Diterpenoids Plants Source Classification Taxus wallichiana var. mairei (Lemee & H. Léveillé) L. K. Fu & Nan Li	TNF Receptor PI3K Reactive Oxygen Species (ROS) Interleukin Related
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice .

HY-N12693

Isobiflorin	Myrtaceae Syzygium aromaticum (L.) Merr. & L.M.Perry Plants Saccharides Monosaccharides Source Classification	Others
Isobiflorin is an anti-inflammatory agent and can be isolated from Syzygium aromaticum. Isobiflorin inhibits LPS-induced PGE2 production with an IC₅₀ value of 46.0 μM .

HY-N8104

15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid	Triterpenes Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Inflammation/Immunology Source Classification	Others
15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid, a Lanostane triterpenoid, possesses NO production inhibitory activities of LPS-induced microglia .

HY-N12283

NF-κB-IN-13	Natural Products Thymelaeaceae Plants Aquilaria sinensis (Lour.) Spreng. Source Classification	NF-κB
NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .

HY-N9866

Grasshopper ketone	Natural Products Actaea dahurica Turcz. ex Fisch. & C. A. Mey. Plants Rhamnaceae Source Classification	Others
It is a bioactive compound with anti-inflammatory activity that inhibits LPS-induced NO production in RAW 264.7 cells and acts by inhibiting the phosphorylation of MAPK (ERK, JNK and p38) and NF-κB p65. Grasshopper ketone, as an ingredient, has shown its potential in anti-inflammatory inhibition .

HY-N1330

Rubranol	Phenols Polyphenols Alnus formosana (Burkill) Makino Plants Betulaceae Source Classification	NO Synthase
Rubranol is an inhibitor of NO Synthase. Rubranol inhibits LPS-induced NO production in activated macrophages with 74% inhibition .

HY-N2053

Physalin L	Natural Products Physalis minima Linn. Solanaceae Plants Source Classification	NO Synthase Endogenous Metabolite
Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity .

HY-N1531

Randaiol MagNOtriol A	Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Polyphenols Plants Source Classification	NO Synthase
Randaiol is an antioxidant that can be isolated from the stem bark of Magnolia officinalis. Randaiol inhibits LPS-induced NO production and has anti-inflammatory and antioxidant activities .

HY-N2968

Bullatantriol (+)-Bullatantriol	Natural Products Araceae Homalomena aromatica Gagnep. Plants Source Classification	Others
Bullatantriol ((+)?-?Bullatantriol) can be isolated from the roots of Homalomena aromatica. Bullatantriol can promote the proliferation and differentiation of osteoblasts. Bullatantriol also inhibits LPS-induced NO production in BV2 cells .

HY-N8984

Kanshone B	Natural Products Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae Source Classification	Others
Kanshone B (Compound 5) is isolated from the natural Nardostachys chinensis. Kanshone B shows inhibitory activity against LPS-induced NO production (IC₅₀=11.5 μM) .

HY-N2794

9-Hydroxy-α-lapachone α-Dihydrocaryopterone	Quinones Catalpa ovata G. Don Monophenols Phenols Plants Bignoniaceae Naphthalene Quinones Source Classification	NO Synthase
9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) is a natural phenol, exhibits potent inhibitory effects with an IC₅₀ of 4.64 µM on LPS-induced NO production in RAW 264.7 cells .

HY-N12347

α-Glucosidase-IN-37	Ketones, Aldehydes, Acids Amomum villosum Lour. Plants Source Classification Zingiberaceae	Others
α-Glucosidase-IN-37 (Compound 11) moderately inhibits LPS-induced NO production with an IC₅₀ value of 23.7 μM in macrophages. α-Glucosidase-IN-37 has weak inhibitory activity against α-Glucosidase .

HY-N15566

Theleganbanin D	Microorganisms Phenols Polyphenols Source Classification	Drug Derivative
Theleganbanin D is a p-terphenyl derivative found in the Thelephora ganbajun. Theleganbanin D inhibits TNF-α, IL-6, and IL-1β production in LPS-induced BV-2 microglial cells. Theleganbanin D is promising for research of neurodegenerative diseases .

HY-N9000

Loganic acid 6′-O-β-D-glucoside	Classification of Application Fields Ketones, Aldehydes, Acids Gentianaceae Plants Inflammation/Immunology Disease Research Fields Gentiana rhodantha Franch. ex Hemsl. Source Classification	TNF Receptor
Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells .

HY-W670564A

(4S)-10-Nor-calamenen-10-one	Structural Classification Terpenoids Sesquiterpenes Plants Alpinia oxyphylla Miq. Source Classification Zingiberaceae	NO Synthase
(4S)-10-Nor-calamenen-10-one (Compound 15) enhances LPS-induced NO production by microglia. (4S)-10-Nor-calamenen-10-one is an eudesmane sesquiterpene that can be isolated from Alpinia oxyphylla .

HY-N3548

Catalpalactone	Natural Products Catalpa ovata G. Don Plants Bignoniaceae Source Classification	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-N0498R

Nitidine chloride (Standard)	Alkaloids Structural Classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Source Classification	Reference Standards Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N12964

4-Hydroxycanthin-6-one	Alkaloids Simaroubaceae Ailanthus altissima (Mill.) Swingle Quinoline Alkaloids Plants Source Classification	Others
4-Hydroxycanthin-6-one is a novel quinoline alkaloid isolated from the stem bark of the tree Ailanthus altissima. Five other known compounds were also found in the study. The structures of the new compounds were determined by interpretation of physical and spectroscopic data, and their absolute configurations were determined by electronic circular dichroism spectroscopy and quantum chemical calculations. These compounds showed significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells, showing potential anti-inflammatory properties .

HY-N17534

3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester	Structural Classification Phenols Polyphenols Plants Compositae Erythrina latissima E. Mey. Source Classification	Drug Derivative
3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester is a Caffeoylquinic acid derivative. 3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester can be isolated from Aster tataricus. 3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester does not inhibit LPS-induced nitric oxide production .

HY-N15570

2-O-Methylatromentin	Microorganisms Phenols Polyphenols Source Classification	Interleukin Related TNF Receptor
2-O-Methylatromentin is an anti-neuroinflammatory agent. 2-O-Methylatromentin shows inhibitory activity on the production of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β in Lipopolysaccharides (HY-D1056) (LPS) -induced BV-2 microglial cells. 2-O-Methylatromentin can be used for the study of neuroinflammatory related diseases .

HY-N16677

Abiesadine I	Structural Classification Pinaceae Terpenoids Pityrogramma triangularis Diterpenoids Plants Source Classification	NO Synthase
Abiesadine I is a diterpenoid inhibitor targeting LPS-induced NO production (IC₅₀>100 μg/mL) that can be isolated from Abies georgei. Abiesadine I inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, exhibiting anti-inflammatory activity .

HY-N13831

Swietenidine B	Structural Classification Alkaloids Dictamnus dasycarpus Turcz. Rutaceae Quinoline Alkaloids Plants Source Classification	Others
Swietenidine B is a quinoline alkaloid that can be isolated from the root bark of Dictamnus dasycarpus. Swietenidine B does not show significant activity in inhibiting NO production in LPS-induced BV-2 microglial cells .

HY-N19816

7-O-Methyl glabranin	Structural Classification Flavonoids Leguminosae Isoflavanones Plants Cajanus cajan (L.) Millsp. Source Classification	TNF Receptor Interleukin Related
7-O-Methyl glabranin is a flavonoid compound and also an inhibitor of LPS-induced TNF-α and IL-1β production. 7-O-Methyl glabranin can be used in the research of diseases such as inflammation .

HY-N13781

(-)-Sesamin 2,2'-diol	Acourtia cordata (Cerv.) B.L.Turner Structural Classification Labiatae Lignans Phenylpropanoids Plants Source Classification	NO Synthase
(-)-Sesamin 2,2'-diol is a nitric oxide (NO) production inhibitor with an IC₅₀ of 310 μM for inhibiting LPS-induced NO production. (-)-Sesamin 2,2'-diol can be isolated from the aerial parts of Isodon japonicus. (-)-Sesamin 2,2'-diol abrogates NO production in LPS-stimulated macrophages without inducing cytotoxicity .

HY-N11737

Monasfluore A	Structural Classification Natural Products Microorganisms Source Classification	Drug Derivative
Monasfluore A is an azaphenanthrenone derivative with antioxidant activity. Monasfluore A inhibits LPS-induced nitric oxide production. Monasfluore A scavenges DPPH and superoxide anion free radicals. Monasfluore A exerts cellular antioxidant activity in oxidatively damaged colon adenocarcinoma cells. Monasfluore A shows no antiproliferative effect on human laryngeal cancer cells and colon adenocarcinoma cells .

HY-N17400

(22E,24R)-23-Methylergosta-7,22-diene-3β,5α,6β-triol	Structural Classification Tetracyclic Triterpenoids Microorganisms Terpenoids Steroids Source Classification	Others
(22E,24R)-23-Methylergosta-7,22-diene-3β,5α,6β-triol (Compound 7) is an Ergosteroid. (22E,24R)-23-Methylergosta-7,22-diene-3β,5α,6β-triol can be isolated from Penicillium herquei. (22E,24R)-23-Methylergosta-7,22-diene-3β,5α,6β-triol exhibits no obvious inhibitory activities against NO production induced by LPS .

HY-N19427

25S-Anguivioside XV	Structural Classification Solanum nigrum Linn. Solanaceae Plants Steroids Source Classification	NO Synthase
25S-Anguivioside XV (Compound 8) is a steroidal glycoside. 25S-Anguivioside XV is isolated from the unripe berries of Solanum nigrum L. 25S-Anguivioside XV inhibits LPS-induced NO production with an IC₅₀ of 49.35 μM. 25S-Anguivioside XV exhibits antiproliferative activity against hepatoma cells .

HY-N15564

Theleganbanin B	Microorganisms Phenols Polyphenols Source Classification	Drug Derivative
Theleganbanin B is a p-terphenyl derivative found in the Thelephora ganbajun. Theleganbanin B inhibits TNF-α, IL-6, and IL-1β production in LPS-induced BV-2 microglial cells. Theleganbanin B inhibits the phosphorylation of JAK2/STAT3. Theleganbanin B is promising for research of neurodegenerative diseases .

Cat. No.	상품명	Chemical Structure

HY-N5060S

Estragole-d4

Estragole-d₄ is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular ROS production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity [10] .

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