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KC01 is an effective inhibitor of ABHD16A, with IC50s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages .

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KC01 Chemical Structure

KC01 Chemical Structure

CAS No. : 1646795-59-6

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KC01 Related Antibodies

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Description

KC01 is an effective inhibitor of ABHD16A, with IC50s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages [1].

IC50 & Target

90 nM for hABHD16A and 520 nM for mABHD16A[1]
In Vitro

KC01 (0-20 μM, 30 min) is a potent inhibitor of ABHD16A with an IC50 < 90 nM[1].
KC01 (1 μM, 4 h) significantly reduces lyso-PSs in colon cancer cells (COL205, K562, and MCF7)[1].
KC01 (1 μM, 4 h) reduces lyso-PS and LPS-induced cytokine production in mouse macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KC01 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293T
Concentration: 0 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM, 2 μM, 5 μM, 10 μM, 20 μM
Incubation Time: 30 min
Result: Showed KC01 inhbited ABHD16A in a concentration-dependent manner.
Molecular Weight

365.55

Formula

C22H39NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N)CCCC/C=C1C(OC\1CCCCCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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KC01 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KC011646795-59-6KC 01KC-01OthersinflammationABHD16A inhibitionInhibitorinhibitorinhibit

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