(3S)-Tanzisertib hydrochloride
(3S)-Tanzisertib (hydrochloride) ((3S)-CC-930 (hydrochloride)) is an orally active JNK inhibitor (IC50 values for JNK1, JNK2, and JNK3 are 61, 7, and 6 nM, respectively). (3S)-Tanzisertib (hydrochloride) selectively inhibits ERK1, p38α, and EGFR (IC50 = 0.48, 3.4, and 0.38 μM, respectively). (3S)-Tanzisertib (hydrochloride) inhibits LPS-induced TNFα production in an acute rat PK-PD model. (3S)-Tanzisertib (hydrochloride) can be used in idiopathic pulmonary fibrosis (IPF) research.
For research use only. We do not sell to patients.
- CAS No.: 2517855-91-1
- Formula: C21H24ClF3N6O2
- Molecular Weight:484.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
|
JNK1 61 nM (IC50) |
JNK2 7 nM (IC50) |
JNK3 6 nM (IC50) |
ERK1 0.48 μM (IC50) |
p38α 3.4 μM (IC50) |
| Species | Dose | Route | Indicator | value |
|---|---|---|---|---|
| Rat | 2 mg/kg | i.v. | CL | 39 mL/min/kg |
| Rat | 2 mg/kg | i.v. | AUC | 1.9 |
| Rat | 2 mg/kg | i.v. | MRT | 0.7 hr |
Chemical Information
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CAS No. 2517855-91-1
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Molecular Weight 484.90
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Formula C21H24ClF3N6O2
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SMILES
OC(CC1)CCC1NC2=NC=C3C(N([C@H]4CCOC4)C(NC5=C(C=C(C=C5F)F)F)=N3)=N2.Cl
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Synonyms
(3S)-CC-930 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(3S)-Tanzisertib hydrochloride Related Classifications
HY-15495B Related Classifications
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