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Cat. No.: HY-N13729

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Stephalonine P

Stephalonine P is a hasubanan-type alkaloid anti-inflammatory agent with neuroprotective effects against neuroinflammation. Stephalonine P regulates post-ischemic inflammatory responses by inhibiting NO production in LPS-activated BV2 microglia (IC₅₀=34.01 μM), thereby reducing microglial activation and neuronal damage. Stephalonine P can be isolated from the whole plant of Stephania japonica. Stephalonine P can be used in research on stroke and other neuroinflammation-related diseases.

For research use only. We do not sell to patients.

CAS No.: 2376309-57-6
Formula: C₃₀H₃₅NO₇
Molecular Weight:521.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Stephalonine P Chemical Structure

CAS No.: 2376309-57-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Hot Topics (1)
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All NO Synthase Isoforms :

In Vitro

Stephalonine P (1-100 µM; 24 h) inhibits NO production in LPS-induced BV2 microglial cells (IC₅₀ = 34.01 ± 1.52 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2376309-57-6
Molecular Weight 521.60
Formula C₃₀H₃₅NO₇
SMILES

CO[C@@]12[C@]34[C@@](C[C@H]([C@H]2OC)OC(/C=C/C5=CC=CC=C5)=O)(CCN4C)C6=C(OC)C(OC)=CC=C6[C@@](O1)([H])C3
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiao J, et al. Natural neuroprotective alkaloids from Stephania japonica (Thunb.) Miers. Bioorg Chem. 2019;91:103175. [Content Brief]

Hot Topics

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Topics Microglia-Neuron Crosstalk & Brain Homeostasis
Microglia-neuron crosstalk refers to the bidirectional communication network between microglia and neurons mediated by receptor-ligand interactions, cell-cell contacts, and soluble signaling molecules.

2026-06-18

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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