2376309-57-6
Chemical Structure
Stephalonine P
- CAS No.: 2376309-57-6
- Formula:C30H35NO7
- Molecular Weight:521.60
InChIKey: DBIVPILOXIUPNX-SQEYGPMISA-N
SMILES: CO[C@@]12[C@]34[C@@](C[C@H]([C@H]2OC)OC(/C=C/C5=CC=CC=C5)=O)(CCN4C)C6=C(OC)C(OC)=CC=C6[C@@](O1)([H])C3
Biological Activity: Stephalonine P is a hasubanan-type alkaloid anti-inflammatory agent with neuroprotective effects against neuroinflammation. Stephalonine P regulates post-ischemic inflammatory responses by inhibiting NO production in LPS-activated BV2 microglia (IC50=34.01 μM), thereby reducing microglial activation and neuronal damage. Stephalonine P can be isolated from the whole plant of Stephania japonica. Stephalonine P can be used in research on stroke and other neuroinflammation-related diseases[1].
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Stephalonine P | Stephalonine P is a hasubanan-type alkaloid anti-inflammatory agent with neuroprotective effects against neuroinflammation. Stephalonine P regulates post-ischemic inflammatory responses by inhibiting NO production in LPS-activated BV2 microglia (IC50=34.01 μM), thereby reducing microglial activation and neuronal damage. Stephalonine P can be isolated from the whole plant of Stephania japonica. Stephalonine P can be used in research on stroke and other neuroinflammation-related diseases. | |||||||||||||||||||||
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Keywords
