2. Neuronal Signaling Metabolic Enzyme/Protease Cell Cycle/DNA Damage PI3K/Akt/mTOR Stem Cell/Wnt
  3. Cholinesterase (ChE) HSP GSK-3 Amyloid-β
  4. AChE/BChE-IN-37

AChE/BChE-IN-37 is a blood-brain barrier-permeable AChE/BChE inhibitor, with an IC50 of 73.65 μM against electric eel-derived AChE and an IC50 of 82.93 μM against horse-derived BChE. AChE/BChE-IN-37 exhibits chelating activity towards Cu2+, Ca2+, Mg2+, Fe2+ and Zn2+. AChE/BChE-IN-37 interacts with HSP90AA1 and GSK-3β. AChE/BChE-IN-37 inhibits the self-induced aggregation of Aβ1-42. AChE/BChE-IN-37 suppresses LPS-induced NO production in cells. AChE/BChE-IN-37 can be used in research related to Alzheimer's disease and inflammatory diseases.

For research use only. We do not sell to patients.

AChE/BChE-IN-37

AChE/BChE-IN-37 Chemical Structure

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AChE/BChE-IN-37 Related Antibodies

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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GSK-3 GSK-3α GSK-3β

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Description

AChE/BChE-IN-37 is a blood-brain barrier-permeable AChE/BChE inhibitor, with an IC50 of 73.65 μM against electric eel-derived AChE and an IC50 of 82.93 μM against horse-derived BChE. AChE/BChE-IN-37 exhibits chelating activity towards Cu2+, Ca2+, Mg2+, Fe2+ and Zn2+. AChE/BChE-IN-37 interacts with HSP90AA1 and GSK-3β. AChE/BChE-IN-37 inhibits the self-induced aggregation of Aβ1-42. AChE/BChE-IN-37 suppresses LPS-induced NO production in cells. AChE/BChE-IN-37 can be used in research related to Alzheimer's disease and inflammatory diseases[1].

IC50 & Target[1]

electric eel AChE

73.65 μM (IC50)

equine serum BChE

82.93 μM (IC50)

GSK-3β

 

HSP90AA1

 

In Vitro

AChE/BChE-IN-37 (multiple concentration gradients; 15 min compound + enzyme, 10 min substrate addition) potently inhibits electric eel-derived AChE with an IC50 of 73.65 μM[1].
AChE/BChE-IN-37 (multiple concentration gradients; 15 min compound + enzyme, 10 min substrate addition) inhibits horse serum-derived BChE with an IC50 of 82.93 μM[1].
AChE/BChE-IN-37 (25 μM; 24 h) inhibits Aβ1-42 aggregation by 35.30% at a concentration of 25 μM[1].
AChE/BChE-IN-37 (25-200 μM; 24 h) shows no significant cytotoxicity in BV2 cells at concentrations up to 150 μM, with mild cytotoxicity observed at 200 μM[1].
AChE/BChE-IN-37 (25 μM; 3 h) exhibits chelating abilities with Cu2+, Ca2+, Mg2+, Fe2+, and Zn2+ ions[1].
AChE/BChE-IN-37 (25-200 μM; 24 h pre-incubation, 24 h LPS stimulation) potently inhibits LPS-induced NO production in BV2 cells with an IC50 of 31.42 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BChE-IN-37 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: BV2 microglial cells
Concentration: 25-200 μM
Incubation Time: 24 h
Result: Showed no significant cytotoxicity at concentrations up to 150 μM, with BV2 cell survival rate greater than 85%.
Exhibited mild cytotoxicity at 200 μM, with cell survival rate around 80%.
Molecular Weight

432.46

Formula

C26H22F2N2O2
SMILES

O=C(C1=CC=C(N2CCN(C(C3=CC=C(F)C(F)=C3)=O)CC2)C=C1)/C=C/C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE/BChE-IN-37 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-37Cholinesterase (ChE)HSPGSK-3Amyloid-βHeat shock proteinsGlycogen synthase kinase-3Glycogen synthase kinase 3β-amyloid peptideAβAbetaGSK-3βhorseICR micebutyrylcholinesteraseAβ1-42Alzheimer’s diseaseBV2 cellselectric eelHSP90AA1acetylcholinesteraseInhibitorinhibitorinhibit

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