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Pathways Recommended: Anti-infection
Results for "

Biofilm infections

" in MedChemExpress (MCE) Product Catalog:

137

Inhibitors & Agonists

1

Screening Libraries

4

Fluorescent Dyes

3

Biochemical Assay Reagents

17

Peptides

27

Natural
Products

6

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1369A
    Imipenem
    30+ Cited Publications

    N-Formimidoyl thienamycin; MK0787

    		 Antibiotic Bacterial Infection
    Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .
    Imipenem
  • HY-B0593
    Ceftazidime
    Maximum Cited Publications
    42 Publications Verification

    GR20263

    		 Beta-lactamase Bacterial Antibiotic Infection Cancer
    Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
    Ceftazidime
  • HY-B1369
    Imipenem monohydrate
    Maximum Cited Publications
    35 Publications Verification

    N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate

    		 Antibiotic Bacterial Infection
    Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .
    Imipenem monohydrate
  • HY-119726
    Fosmanogepix

    APX001; E1211

    		 Fungal Infection Inflammation/Immunology Cancer
    Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research .
    Fosmanogepix
  • HY-W010155
    Tryptophol
    2 Publications Verification

    Indole-3-ethanol

    		 Endogenous Metabolite Apoptosis Caspase Bacterial Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy .
    Tryptophol
  • HY-B1159
    Nitroxoline
    4 Publications Verification

    8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol

    		 Bacterial Antibiotic Apoptosis Autophagy Infection Cancer
    Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research .
    Nitroxoline
  • HY-B0593A
    Ceftazidime pentahydrate
    Maximum Cited Publications
    42 Publications Verification

    GR20263 pentahydrate

    		 Beta-lactamase Bacterial Antibiotic Infection Cancer
    Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
    Ceftazidime pentahydrate
  • HY-B0914
    10-Undecenoic acid,98% (stabilized with TBC)
    2 Publications Verification

    Undecylenic acid

    		 Environmental Pollutants Bacterial Fungal Proteasome Amyloid-β Reactive Oxygen Species (ROS) Infection Neurological Disease Endocrinology Cancer
    10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .
    10-Undecenoic acid,98% (stabilized with TBC)
  • HY-30236
    5-Bromoindole

    		Bacterial Infection
    5-Bromoindole is an antibacterial agent with a MIC of 200 μg/mL. 5-Bromoindole inhibits biofilm and curli formation, reduces swarming motility and swimming motility. 5-Bromoindole can be used for the research of enterohemorrhagic escherichia coli o157:h7 infection .
    5-Bromoindole
  • HY-N2036
    Mosloflavone
    1 Publications Verification

    		 TNF Receptor Enterovirus Bacterial Infection
    Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.
    Mosloflavone
  • HY-W040128
    Kanamycins sulfate

    		Antibiotic Autophagy JNK Bcl-2 Family Infection
    Kanamycins sulfate is a blood-brain barrier-permeable JNK1 and Bcl-2 modulator as well as an antibiotic, with broad-spectrum antibacterial, and biofilm-inhibiting activities, and it induces autophagy. Kanamycins sulfate promotes Bcl-2 phosphorylation to upregulate autophagy levels, triggering changes such as mitochondrial swelling and endoplasmic reticulum expansion. Consequently, it causes reversible neuronal damage in the dorsal cochlear nucleus without inducing significant neuronal apoptosis. In the presence of exogenous alanine or glucose, Kanamycins sulfate effectively kills drug-resistant bacteria, restores drug sensitivity of multidrug-resistant bacteria, and alleviates urinary tract and kidney infections in mice. Kanamycins sulfate can be applied to scientific research related to Mycobacterium tuberculosis, salmonellosis, brucellosis, shigellosis, urinary tract infections, and reversible neurotoxicity .
    Kanamycins sulfate
  • HY-Y1718
    Tridecanoic acid
    1 Publications Verification

    N-Tridecanoic acid

    		 Endogenous Metabolite Bacterial Infection
    Tridecanoic acid (N-Tridecanoic acid) is a medium-chain saturated fatty acid and inhibitor with no antibacterial activity against enterohemorrhagic E. coli (EHEC). When used in combination with Ciprofloxacin (HY-B0356) or Ampicillin (HY-B0522), Tridecanoic acid suppresses persister formation in exponentially growing E. coli and EHEC, but exerts no inhibitory effect on persister formation induced by Kanamycin (HY-16566) or in stationary-phase cells. Tridecanoic acid inhibits biofilm formation in EHEC. It can be used in the research of bacterial infections .
    Tridecanoic acid
  • HY-124833
    Quinalizarin

    		Casein Kinase Apoptosis Fungal Reactive Oxygen Species (ROS) Caspase MDM-2/p53 PARP Bcl-2 Family Akt ERK STAT JNK p38 MAPK CDK Infection Cancer
    Quinalizarin is a protein kinase CK2 inhibitor with a Ki of 0.052 μM. Quinalizarin exhibits antifungal and anticancer activities. Quinalizarin induces ROS production, apoptotic signaling, mitochondrial pathway activation, cell cycle arrest, and cytotoxicity in cancer cells. Quinalizarin inhibits hyphal growth, biofilm formation, and mature biofilm integrity of Candida albicans. Quinalizarin can be used in research related to cancer and fungal infections .
    Quinalizarin
  • HY-121310
    Phthalocyanine

    		MOFs Bacterial Infection Cancer
    Phthalocyanine is a photosensitizer. Phthalocyanine has a light-killing effect on bacterial biofilms, effectively inactivating bacteria. Phthalocyanine can be linked to anticancer drugs to target cancer. Phthalocyanine can also be used to develop chemical sensors for studying microbial infections and tumors .
    Phthalocyanine
  • HY-B1369R
    Imipenem monohydrate (Standard)

    N-Formimidoyl thienamycin monohydrate (Standard); MK0787 monohydrate (Standard)

    		 Reference Standards Antibiotic Bacterial Infection
    Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .
    Imipenem monohydrate (Standard)
  • HY-W014141
    5,6-O-Isopropylidene-L-ascorbic acid

    L-Ascorbic acid 5,6-acetonide

    		 Biochemical Assay Reagents Infection
    5,6-O-Isopropylidene-L-ascorbic acid (L-Ascorbic acid 5,6-acetonide) is an organic compound and a derivative of L-ascorbic acid (vitamin C). 5,6-O-Isopropylidene-L-ascorbic acid inhibits biofilm formation by pathogenic bacteria. 5,6-O-Isopropylidene-L-ascorbic acid is applicable to studies related to bacterial infections .
    5,6-O-Isopropylidene-L-ascorbic acid
  • HY-P10233A
    SAAP 148 TFA

    		Bacterial Infection
    SAAP 148 TFA is a synthetic antimicrobial peptide (bacteria) that interacts with and disrupts the lipid bilayer of bacterial cytoplasmic membranes, thereby inducing changes in membrane permeability and bacterial death. SAAP 148 TFA kills drug-resistant, multidrug-resistant and persister bacterial strains, inhibits biofilm formation, eliminates established biofilms, and blocks bacterial colonization on implant surfaces. SAAP 148 TFA retains its activity after modification or immobilization, exhibits variable cytotoxicity in different human cell models, and shows reduced efficacy in protein-rich environments. SAAP 148 TFA can be used in infection-related research .
    SAAP 148 TFA
  • HY-77785
    2-Amino-5-chlorobenzophenone
    1 Publications Verification

    5-Chloro-2-aminobenzophenone

    		 Drug Intermediate Infection Neurological Disease
    2-Amino-5-chlorobenzophenone (5-Chloro-2-aminobenzophenone) is a chemical intermediate. Derivatives of 2-Amino-5-chlorobenzophenone serve as skeletal muscle relaxants. 2-Amino-5-chlorobenzophenone acts as a starting material for the synthesis of anti-biofilm 2-amino-5-chlorobenzophenone Schiff bases. 2-Amino-5-chlorobenzophenone is applicable to research related to bacterial infections .\n
    2-Amino-5-chlorobenzophenone
  • HY-B0593AR
    Ceftazidime pentahydrate (Standard)

    GR20263 pentahydrate (Standard)

    		 Beta-lactamase Reference Standards Bacterial Antibiotic Infection Cancer
    Ceftazidime (pentahydrate) (Standard) is the analytical standard of Ceftazidime (pentahydrate). This product is intended for research and analytical applications. Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
    Ceftazidime pentahydrate (Standard)
  • HY-B0593R
    Ceftazidime (Standard)

    GR20263 (Standard)

    		 Beta-lactamase Reference Standards Bacterial Antibiotic Infection
    Ceftazidime (Standard) is the analytical standard of Ceftazidime. This product is intended for research and analytical applications. Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
    Ceftazidime (Standard)
  • HY-W037825
    Pterin

    		Bacterial Infection Cancer
    Pterin is a Pteridine with antibacterial activity, which is found in C. croceus. Pterin reduces the proliferation and biofilm production in E. coli, P. aeruginosa, and S. mutans. Pterin is promising for research of cancers and infections .
    Pterin
  • HY-Y1718S1
    Tridecanoic acid-d25

    N-Tridecanoic acid-d25

    		 Isotope-Labeled Compounds Endogenous Metabolite Bacterial Cancer
    Tridecanoic acid-d25 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .
    Tridecanoic acid-d25
  • HY-Y1718S
    Tridecanoic acid-d2

    N-Tridecanoic acid-d2

    		 Isotope-Labeled Compounds Endogenous Metabolite Bacterial Infection
    Tridecanoic acid-d2 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .
    Tridecanoic acid-d2
  • HY-W010155R
    Tryptophol (Standard)

    Indole-3-ethanol (Standard)

    		 Reference Standards Endogenous Metabolite Apoptosis Caspase Bacterial Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Tryptophol (Standard) (Indole-3-ethanol (Standard)) is an analytical standard of Tryptophol (HY-W010155). This product is intended for use in research and analytical applications.Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces Apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy.
    Tryptophol (Standard)
  • HY-W750342
    Tryptophol-d4

    Indole-3-ethanol-d4

    		 Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Caspase Bacterial Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Tryptophol-d4 (Indole-3-ethanol-d4) is the deuterium labeled Tryptophol (HY-W010155). Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy .
    Tryptophol-d4
  • HY-P5486
    Tet-20

    		Bacterial Others
    Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)
    Tet-20
  • HY-P10233
    SAAP 148

    		Bacterial Infection
    SAAP 148 is a synthetic antimicrobial peptide (bacteria) that interacts with and disrupts the lipid bilayer of bacterial cytoplasmic membranes, thereby inducing changes in membrane permeability and bacterial death. SAAP 148 kills drug-resistant, multidrug-resistant and persister bacterial strains, inhibits biofilm formation, eliminates established biofilms, and blocks bacterial colonization on implant surfaces. SAAP 148 retains its activity after modification or immobilization, exhibits variable cytotoxicity in different human cell models, and shows reduced efficacy in protein-rich environments. SAAP 148 can be used in infection-related research .
    SAAP 148
  • HY-149734
    MA220607

    		Bacterial Infection
    MA220607 is a FtsZ protein inhibitor with activity against both Gram-positive and Gram-negative bacteria. MA220607 inhibits bacterial growth and shows low bacterial resistance frequency. MA220607 increases bacterial membrane permeability and alters proton gradients. MA220607 blocks the formation of bacterial biofilms. MA220607 can be used in studies of bacterial infections .
    MA220607
  • HY-P5641
    Pleurocidin
    1 Publications Verification

    		 Bacterial p38 MAPK NF-κB NADH Dehydrogenase Antibiotic Infection Inflammation/Immunology
    Pleurocidin is an Antimicrobial peptide. Pleurocidin is derived from the skin mucosa or intestinal secretions of Pseudopleuronectes americanus. Pleurocidin inhibits the expression of key proteins in the MAPK and NF-κB inflammatory signaling pathways. Pleurocidin alters serum inflammatory and immune cytokine levels, regulates the down-regulation of tight junction proteins, and modulates the intestinal flora. Pleurocidin exerts antibacterial activity by inducing bacterial membrane damage, hydroxyl radical formation, and NADH depletion, and also produces a synergistic effect with Antibiotics. Pleurocidin alleviates DSS-induced ulcerative colitis. Pleurocidin can be used for research on ulcerative colitis, bacterial infections, and bacterial biofilm-related infections .
    Pleurocidin
  • HY-P11165
    DRGN-1

    		Bacterial Infection
    DRGN-1 is an antimicrobial peptide. DRGN-1 exhibits potent antimicrobial and anti-biofilm activities, inhibiting both Gram-negative and Gram-positive bacteria, with an EC50 range of 0.50-4.62 μM. DRGN-1 exerts its antimicrobial effect by disrupting bacterial membrane permeability and slightly depolarizing the membrane potential. DRGN-1 inhibits the formation of biofilms of single bacterial species and mixed species of Pseudomonas aeruginosa and Staphylococcus aureus. DRGN-1 can significantly promote the healing of uninfected and mixed biofilm-infected mouse wounds. DRGN-1 can be used for the study of infections .
    DRGN-1
  • HY-N16657
    Fusaricidin B

    LI-F 04b

    		 Bacterial Infection
    Fusaricidin B (LI-F 04b) is one of the components of a lipopeptide biosurfactant extracted from the marine bacterium Paenibacillus polymyxa. Fusaricidin B can significantly inhibit the formation of multiple single species biofilms, including Gram positive and Gram negative bacteria. Fusaricidin B also has inhibitory effects on complex biofilms and can effectively destroy mature biofilms that have already formed. Fusaricidin B can be used for research on bacterial infections .
    Fusaricidin B
  • HY-B1159S
    Nitroxoline-d4

    8-Hydroxy-5-nitroquinoline-d4; 5-Nitro-8-quinolinol-d4

    		 Bacterial Autophagy Antibiotic Infection Cancer
    Nitroxoline-d4 is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe 2+ and Zn 2+ ions from the biofilm matrix .
    Nitroxoline-d4
  • HY-N15548
    Armeniaspirol A

    Armeniaspirole A

    		 Bacterial Infection
    Armeniaspirol A (Armeniaspirole A) is an antibacterial agent targeting Helicobacter pylori cell membranes. Armeniaspirol A induces membrane permeabilization, cytoplasmic leakage, and biofilm inhibition/eradication. Armeniaspirol A is promising for research of H. pylori infection .
    Armeniaspirol A
  • HY-B1159R
    Nitroxoline (Standard)

    8-Hydroxy-5-nitroquinoline (Standard); 5-Nitro-8-quinolinol (Standard)

    		 Reference Standards Bacterial Antibiotic Apoptosis Autophagy Infection Cancer
    Nitroxoline (Standard) is the analytical standard of Nitroxoline. This product is intended for research and analytical applications. Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research .
    Nitroxoline (Standard)
  • HY-179389
    XDS-23

    		Bacterial Glutathione S-transferase Elastase Infection
    XDS-23 is a selective biofilm inhibitor with an IC50 of 1.26 µM against Pseudomonas aeruginosa. XDS-23 exerts a dual inhibitory effect on the LasI/LasR System (las) and Pseudomonas Quinolone Signal System (pqs). XDS-23 suppress the production of key virulence factors including elastase, pyocyanin, and extracellular polysaccharides. XDS-23 exhibits synergistic antibacterial activity and can enhance the efficacy of multiple antibiotics in both in vitro and in vivo models, while maintaining a favorable safety profile. XDS-23 can be employed for research in combating biofilm-mediated drug-resistant P. aeruginosa infections .
    XDS-23
  • HY-146811
    HSGN-94

    		Bacterial Inflammation/Immunology
    HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model .
    HSGN-94
  • HY-119726A
    Fosmanogepix (tautomerism)

    APX001 (tautomerism); E1211 (tautomerism)

    		 Fungal Infection Inflammation/Immunology
    Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections .
    Fosmanogepix (tautomerism)
  • HY-P11454
    PSM-mec peptide

    		Bacterial Infection
    PSM-mec peptide is a peptide toxin belonging to the phenol-soluble modulin (PSM) superfamily. PSM-mec peptide is encoded by the psm-mec gene and associated with the methicillin resistance gene element (SCCmec). PSM-mec peptide has pro-inflammatory, cytolytic functions and the role of regulating the structure of biofilms. PSM-mec peptide can be mainly used for the pathogenic mechanism and drug resistance research of canine pseudo-intermediate Staphylococcus (S. pseudintermedius) related infections and zoonotic diseases .
    PSM-mec peptide
  • HY-P11055
    IKFQFHFD

    		Bacterial Infection
    IKFQFHFD is a pH-responsive and self-assembling peptide. IKFQFHFD is biocompatible at neutral pH and becomes an antimicrobial peptide-like molecular structure only at acidic pH. IKFQFHFD can be used for chronic wounds (venous ulcers, diabetic ulcers, and pressure ulcers) induced by biofilm infections research .
    IKFQFHFD
  • HY-124469
    UM-C162

    		Bacterial Infection
    UM-C162, a benzimidazole derivative, can rescue nematodes from a S. aureus infection. UM-C162 prevents the formation of biofilm without interfering with bacterial viability. UM-C162 mediates the disruption of S. aureus hemolysins, proteases and clumping factors production. UM-C162 has the potential to be used as an anti-virulence agent to control S. aureus infections .
    UM-C162
  • HY-163030
    LasB-IN-1

    		Elastase NF-κB p38 MAPK Bacterial Infection Inflammation/Immunology
    LasB-IN-1 (compound 5f) is a potent and orally active inhibitor of LasB (IC50 = 8.7 μM). LasB-IN-1 effectively attenuates elastase production and biofilm formation by P. aeruginosa while alleviating the inflammatory response through downregulating MAPK and NF-κB pathways. LasB-IN-1 is potential to be a novel anti-infective candidate against drug-resistant infections .
    LasB-IN-1
  • HY-142695
    Antibacterial synergist 1

    		Bacterial Infection
    Antibacterial synergist 1 (compound 20P) is a bacterial biofilm inhibitor. Antibacterial synergist 1 inhibits the production of pyocyanin and biofilm formation with IC50s of 8.6 and 4.5 μM, respectively. Antibacterial synergist 1 has the potential for the research of P. aeruginosa infections .
    Antibacterial synergist 1
  • HY-175254
    Antibiofilm agent-17

    		Bacterial Infection
    Antibiofilm agent-17 is a dual-action biofilm inhibitor against Pseudomonas aeruginosa (IC50 = 0.33 μM). Antibiofilm agent-17 inhibits biofilm growth by reducing quorum sensing-mediated virulence production and iron ion acquisition. Antibiofilm agent-17 exhibits synergistic antimicrobial effects in a mouse wound infection model. Antibiofilm agent-17 can be used in research on combating Pseudomonas aeruginosa infections .
    Antibiofilm agent-17
  • HY-149330
    HA5

    		Bacterial Infection
    HA5 inhibits Streptococcus mutans biofilm with an IC50 value of 6.42 μM, without affecting its growth. HA5 also inhibits Streptococcus mutans glucan production and eDNA levels .
    HA5
  • HY-172895
    Quorum sensing-IN-10

    		Bacterial Infection Inflammation/Immunology
    Quorum sensing-IN-10 (10p), an antibacterial synergist, shows significant inhibition of P. aeruginosa virulence, biofilm, and motility, with low toxicity. Quorum sensing-IN-10 (10p) can be used in the research for drug-resistant Pseudomonas aeruginosa infections .
    Quorum sensing-IN-10
  • HY-151442
    Antifungal agent 43

    		Fungal Infection
    Antifungal agent 43 (compound B05) is an antifungal agent. Antifungal agents 43 has antifungal activity by inhibiting biofilm formation. Antifungal agent 43 has low toxicity in human cancer cell lines .
    Antifungal agent 43
  • HY-151440
    Antifungal agent 42

    		Fungal Infection
    Antifungal agent 42 is an antifungal agent. Antifungal agent 42 has an inhibitory effect on lanosterol 14α-demethylase (CYP51) of C.alb.. Antifungal agent 42 inhibits biofilm formation .
    Antifungal agent 42
  • HY-151437
    Antifungal agent 40

    		Fungal Infection
    Antifungal agent 40 is an antifungal agent which extends into the narrow hydrophobic pocket II of C.alb. CYP51. Antifungal agent 40 has an inhibitory effect on lanosterol 14α-demethylase (CYP51). Antifungal agent 40 inhibits biofilm formation .
    Antifungal agent 40
  • HY-163631
    Antibacterial agent 218

    		Fungal Endogenous Metabolite Infection
    Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC50 of 0.25 μg/mL .
    Antibacterial agent 218
  • HY-Y1718S2
    Tridecanoic acid-d9

    N-Tridecanoic acid-d9

    		 Isotope-Labeled Compounds Endogenous Metabolite Bacterial Infection
    Tridecanoic acid-d9 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .
    Tridecanoic acid-d9

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